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Molecules, Volume 24, Issue 8

April-2 2019 - 196 articles

Cover Story: Two highly selective triazole-containing peptidic polo-like kinase 1 (Plk1) polo-box domain (PBD)-binding inhibitors (3d in green and 4b in orange) are depicted, binding within the hydrophobic “cryptic” binding pocket on the surface of the Plk1 PBD (light blue). The placement was guided by our previously reported X-ray crystal structure of PBD-bound parent peptide (2a) (PDB accession code: 3RQ7), whose binding pocket is highlighted in yellow. These ligands retain the high PBD-binding affinity of the parent peptide, while showing desirable enhanced selectivity for the PBD of Plk1 relative to the PBDs of Plk2 and Plk3. View this paper
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Articles (196)

  • Article
  • Open Access
47 Citations
7,629 Views
17 Pages

Topical Application of Cinnamaldehyde Promotes Faster Healing of Skin Wounds Infected with Pseudomonas aeruginosa

  • Thiago A.F. Ferro,
  • Eliene B. Souza,
  • Mariela A.M. Suarez,
  • João F.S. Rodrigues,
  • Domingos M.S. Pereira,
  • Saulo J.F. Mendes,
  • Laoane F. Gonzaga,
  • Márcia C.A.M. Machado,
  • Maria R.Q. Bomfim and
  • João B. Calixto
  • + 4 authors

25 April 2019

Wound healing can be delayed following colonization and infection with the common bacterium Pseudomonas aeruginosa. While multiple therapies are used for their treatment, these are ineffective, expensive, and labour-intensive. Thus, there is an enorm...

  • Article
  • Open Access
21 Citations
6,386 Views
18 Pages

Protein Hydrolysate from Pterygoplichthys disjunctivus, Armoured Catfish, with High Antioxidant Activity

  • Yuchen Guo,
  • Nicholas Michael,
  • Jorge Fonseca Madrigal,
  • Carlos Sosa Aguirre and
  • Paula Jauregi

25 April 2019

Pterygoplichthys disjunctivus, locally named the armoured catfish, is a by-catch of tilapia fishing that accounts for up to 80% of total captured fish in the Adolfo Lopez Mateos dam, in Michoacán, México, affecting the economy of its su...

  • Review
  • Open Access
79 Citations
12,877 Views
22 Pages

Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery

  • Johannes Ottl,
  • Lukas Leder,
  • Jonas V. Schaefer and
  • Christoph E. Dumelin

25 April 2019

The scope of targets investigated in pharmaceutical research is continuously moving into uncharted territory. Consequently, finding suitable chemical matter with current compound collections is proving increasingly difficult. Encoded library technolo...

  • Article
  • Open Access
19 Citations
5,780 Views
13 Pages

Identifying Reducing and Capping Sites of Protein-Encapsulated Gold Nanoclusters

  • Yu-Chen Hsu,
  • Mei-Jou Hung,
  • Yi-An Chen,
  • Tsu-Fan Wang,
  • Ying-Ru Ou and
  • Shu-Hui Chen

25 April 2019

The reducing and capping sites along with their local structure impact photo properties of the red bovine serum albumin-capped Au nanocluster (BSA-AuNC), however, they are hard to identify. We developped a workflow and relevant techniques using mass...

  • Article
  • Open Access
39 Citations
4,542 Views
12 Pages

Synthesis of Telmisartan Organotin(IV) Complexes and their use as Carbon Dioxide Capture Media

  • Angham G. Hadi,
  • Khudheyer Jawad,
  • Emad Yousif,
  • Gamal A. El-Hiti,
  • Mohammad Hayal Alotaibi and
  • Dina S. Ahmed

25 April 2019

Novel, porous, highly aromatic organotin(IV) frameworks were successfully synthesized by the condensation of telmisartan and an appropriate tin(IV) chloride. The structures of the synthesized organotin(IV) complexes were elucidated by elemental analy...

  • Article
  • Open Access
23 Citations
6,666 Views
10 Pages

New UHPLC-QqQ-MS/MS Method for the Rapid and Sensitive Analysis of Ascorbic and Dehydroascorbic Acids in Plant Foods

  • Nieves Baenas,
  • Francisco J. Salar,
  • Raúl Domínguez-Perles and
  • Cristina García-Viguera

25 April 2019

A new method using ultra high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-QqQ-MS/MS) methodology was developed for the determination of ascorbic acid (AA) and dehydroascorbic acid (DHAA) contents in liqui...

  • Article
  • Open Access
30 Citations
5,613 Views
11 Pages

Microfluidics-Based Fabrication of Cell-Laden Hydrogel Microfibers for Potential Applications in Tissue Engineering

  • Gen Wang,
  • Luanluan Jia,
  • Fengxuan Han,
  • Jiayuan Wang,
  • Li Yu,
  • Yingkang Yu,
  • Gareth Turnbull,
  • Mingyu Guo,
  • Wenmiao Shu and
  • Bin Li

25 April 2019

Fibrous hydrogel scaffolds have recently attracted increasing attention for tissue engineering applications. While a number of approaches have been proposed for fabricating microfibers, it remains difficult for current methods to produce materials th...

  • Article
  • Open Access
15 Citations
5,200 Views
10 Pages

25 April 2019

Polymerizations of 1-decene (DC), 1-dodecene (DD), and 1-tetradecene (TD) by Cp*TiMe2(O-2,6-iPr2C6H3) (1)–[Ph3C][B(C6F5)4] (borate) catalyst have been explored in the presence of Al cocatalyst. The polymerizations of DC and DD, in n-hexane cont...

  • Article
  • Open Access
20 Citations
6,764 Views
12 Pages

25 April 2019

The cross-linking and gelation of low-methoxy pectins are basic processes commonly used in different industries. The aim of this research was to evaluate the cross-linking process of the sodium carbonate-soluble pectins (named DASP) extracted from ap...

  • Review
  • Open Access
16 Citations
8,218 Views
58 Pages

…Fell Upas Sits, the Hydra-Tree of Death , or the Phytotoxicity of Trees

  • Vadim G. Lebedev,
  • Konstantin V. Krutovsky and
  • Konstantin A. Shestibratov

25 April 2019

The use of natural products that can serve as natural herbicides and insecticides is a promising direction because of their greater safety for humans and environment. Secondary metabolites of plants that are toxic to plants and insects—alleloch...

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Molecules - ISSN 1420-3049