Special Issue "G-quadruplex and Microorganisms"
Deadline for manuscript submissions: 31 May 2019
G-quadruplexes (G4s) are nucleic acid secondary structures that form in DNA or RNA guanine (G)-rich strands. Four G residues are connected through Hoogsteen-type hydrogen bonds, forming a G-tetrad and two or more G-tetrads can stack on top of each other forming the G4, which is stabilized by coordinating monovalent cations, such as K+.
G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters, where their involvement in the regulation of different biological pathways such as replication, transcription, translation and genome instability has been suggested. In addition to humans, putative G4-forming sequences have been found in other mammalian genomes, plants, yeasts, protozoa, bacteria and viruses. In particular, in the recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes G4 sequences have been found in several human pathogens and bacterial species present in the environment. Bacterial enzymes able to process G4s have also been identified. In viruses, G4s are involved in key steps of the viral life cycle: they been associated with pathogenic mechanisms of the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), the human papilloma, Zika, Ebola, hepatitis C virus and several other virus genomes. G4 binding proteins and mRNA G4s have been implicated in the regulation of the viral genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle, and as therapeutic agents. Moreover, oligonucleotides that fold into G4 have been found to be active against several microorganisms. This Special Issue will focus on G4s involved in microorganisms addressing all the above aspects.
Prof. Sara N. Richter
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- G-quadruplex ligands
- anti-infective agents
- nucleic acids conformation