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Special Issue "Multicomponent Reactions"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 March 2019

Special Issue Editor

Guest Editor
Dr. Cimarelli Cristina

School of Science and Technology – Chemistry Division, University of Camerino, Camerino, Italy
Website | E-Mail
Phone: +39 0737 402241
Interests: stereoselective synthesis; Lewis Acid catalysis; multicomponent reactions; small molecules; heterocycle synthesis; green chemistry

Special Issue Information

Dear Colleagues,

Multicomponent reactions share many features that make them very appealing to organic chemists. According to a commonly-accepted definition, “MCRs are reactions with three and more starting materials where the majority of the atoms of the starting material are incorporated in the product”. MCRs start mixing three or more reagents, continue in one-pot fashion through several reaction steps without human intervention to isolate and separate intermediates and converge on a final product, which, in almost all cases, contains all the atoms of the starting material, with little or no side products. They appear to be ideal for any form of synthesis, because of their high atom economy and bond-forming efficiency, low-cost separation and purification of products, and scarce waste formation. Futhermore they offer the possibility to produce molecular diversity in combinatorial synthesis, and, in many cases, may be adapted to automation. Furthermore, from a purely academic point of view, all multicomponent reactions involve a plethora of chemical reactions, offering the possibility to study many beautiful and interesting chemistry.

Many fields of organic chemistry have been taking advantage of multicomponent reactions; thus, selected papers are welcomed that open new perspectives in MCR chemistry with creative results, and in MCRs applications to the synthesis of various classes of organic compounds, not only in organic synthesis and drug discovery, but also in material science, agriculture, medical devices, imaging, or in other fields, such as solar energy, stem cell therapy or superconductivity.

Dr. Cimarelli Cristina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multicomponent reactions
  • small molecules
  • heterocycle synthesis
  • green chemistry
  • synthetic methodologies

Published Papers (3 papers)

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Research

Open AccessFeature PaperArticle Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction
Molecules 2018, 23(11), 2758; https://doi.org/10.3390/molecules23112758
Received: 5 October 2018 / Revised: 19 October 2018 / Accepted: 22 October 2018 / Published: 25 October 2018
PDF Full-text (1220 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Tetrazoles have been widely studied for their biological properties. An efficient route for large-scale synthesis of 1,5-disubstituted tetrazoles (1,5-DTs) is presented. The strategy exploits a reductive approach to synthetize a cyclic chiral imine substrate which is then converted into the target product through
[...] Read more.
Tetrazoles have been widely studied for their biological properties. An efficient route for large-scale synthesis of 1,5-disubstituted tetrazoles (1,5-DTs) is presented. The strategy exploits a reductive approach to synthetize a cyclic chiral imine substrate which is then converted into the target product through an Ugi-azide three-component reaction (UA-3CR). The final products are equipped with additional functionalities which can be further elaborated for the generation of combinatorial libraries of enantiopure heterocycles. Full article
(This article belongs to the Special Issue Multicomponent Reactions)
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Open AccessArticle Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents
Molecules 2018, 23(9), 2330; https://doi.org/10.3390/molecules23092330
Received: 28 July 2018 / Revised: 30 August 2018 / Accepted: 3 September 2018 / Published: 12 September 2018
PDF Full-text (1179 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC50 = 2.86–36.34 μM), while normal cell line LO2 was less
[...] Read more.
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC50 = 2.86–36.34 μM), while normal cell line LO2 was less sensitive to these hybrids (IC50 = 36.37–248.39 μM). On the whole, among all the compounds tested, compound 4e, with a mean IC50 value of 2.86 μM, was the most active. The novel hybrids may find their pharmaceutical applications after further investigations. Full article
(This article belongs to the Special Issue Multicomponent Reactions)
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Open AccessArticle Synthesis of Novel 1,4-Naphthoquinones Possessing Indole Scaffolds Using In(OTf)3 in Solvent-Free Conditions
Molecules 2018, 23(8), 1954; https://doi.org/10.3390/molecules23081954
Received: 11 July 2018 / Revised: 28 July 2018 / Accepted: 31 July 2018 / Published: 6 August 2018
PDF Full-text (795 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Novel 1,4-naphthoquinones possessing indole scaffolds were prepared by the reaction of 2-hydroxy-1,4-naphthoquinone-substituted salicylic aldehydes and indoles using In(OTf)3 as a catalyst. The method has the advantages of simple operation, mild reaction conditions, and friendly environment. Full article
(This article belongs to the Special Issue Multicomponent Reactions)
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