Molecules, Volume 24, Issue 4 (February-2 2019) – 170 articles
Cover Story (view full-size image): Cistanche tubulosa aqueous extract (CTE) is already used as a botanical prescription drug for treating dementia in China. Our previous studies reported that phenylethanoid glycosides (1-3) of CTE have anti-Alzheimer’s disease (AD) activity by inhibiting amyloid β peptide (Aβ) aggregation and deposition. Metal ions were recently considered a key factor closely related to Aβ aggregation. This study demonstrated that phenylethanoid glycosides would have iron chelating activity. Iron is the essential element in serum and the brain. CTE has a potential anti-AD activity targeting iron chelation-induced Aβ aggregation and deposition. In addition, we further proved that phenylethanoid glycosides would reach the brain. Active CTE component confirmation will be a great help for product quality control and bioavailability studies in the future. View this paper.
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