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Special Issue "Recent Advances in Antimicrobial Biomaterials"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 31 May 2019

Special Issue Editor

Guest Editor
Prof. Naresh Kumar

School of Chemistry, University of New South Wales, UNSW Sydney, Australia
Website | E-Mail
Interests: quorum sensing inhibitors; antimicrobial biomaterials; antimicrobial peptides and mimics; RNAP-σ factor inhibitors; dual-action antimicrobials

Special Issue Information

Dear Colleagues,

Biomaterial-related infection represents a significant public health issue and financial burden on governments and patients around the world. With the long-term overuse and misuse of antibiotics, the situation is likely to get worse in the future with the prevalence of antibiotic-resistant bacteria and increasing adoption of biomedical implants and devices. Antibiotics are no longer the magic bullets they were once thought to be, and, therefore, there is an urgent need for the development of antimicrobial biomaterials to prevent infections before they take hold. Antimicrobial biomaterials have been shown to reduce or prevent bacteria colonization on the biomaterial surface, either through physical, chemical, or biological interactions with the bacterial cell.

Several classes of antimicrobial biomaterials are discussed:

  1. Biomaterials that release antimicrobials
  2. Biomaterials where the antimicrobials are covalently attached
  3. Antifouling Biomaterials
  4. Biomaterials with nano-structured surfaces

Prof. Naresh Kumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access bimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antimicrobial surfaces
  • Antimicrobial coatings
  • Antifouling
  • Bacterial colonization
  • Biofilm
  • Antimicrobial biomaterials
  • Infection control

Published Papers (2 papers)

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Research

Open AccessArticle Edible Chitosan Films and Their Nanosized Counterparts Exhibit Antimicrobial Activity and Enhanced Mechanical and Barrier Properties
Molecules 2019, 24(1), 127; https://doi.org/10.3390/molecules24010127
Received: 2 December 2018 / Revised: 18 December 2018 / Accepted: 25 December 2018 / Published: 31 December 2018
PDF Full-text (3362 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Chitosan and chitosan-nanoparticles were combined to prepare biobased and unplasticized film blends displaying antimicrobial activity. Nanosized chitosans obtained by sonication for 5, 15, or 30 min were combined with chitosan at 3:7, 1:1, and 7:3 ratios, in order to adjust blend film mechanical
[...] Read more.
Chitosan and chitosan-nanoparticles were combined to prepare biobased and unplasticized film blends displaying antimicrobial activity. Nanosized chitosans obtained by sonication for 5, 15, or 30 min were combined with chitosan at 3:7, 1:1, and 7:3 ratios, in order to adjust blend film mechanical properties and permeability. The incorporation of nanosized chitosans led to improvements in the interfacial interaction with chitosan microfibers, positively affecting film mechanical strength and stiffness, evidenced by scanning electron microscopy. Nanosized or blend chitosan film sensitivity to moisture was significantly decreased with the drop in biocomposite molecular masses, evidenced by increased water solubility and decreased water vapor permeability. Nanosized and chitosan interactions gave rise to light biobased films presenting discrete opacity and color changes, since red-green and yellow-blue colorations were affected. All chitosan blend films exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria. The performance of green unplasticized chitosan blend films displaying diverse morphologies has, thus, been proven as a potential step towards the design of nontoxic food packaging biobased films, protecting against spoilage microorganisms, while also minimizing environmental impacts. Full article
(This article belongs to the Special Issue Recent Advances in Antimicrobial Biomaterials)
Figures

Graphical abstract

Open AccessArticle Hydrogen Peroxide Generation of Copper/Ascorbate Formulations on Cotton: Effect on Antibacterial and Fibroblast Activity for Wound Healing Application
Molecules 2018, 23(9), 2399; https://doi.org/10.3390/molecules23092399
Received: 25 July 2018 / Revised: 10 September 2018 / Accepted: 13 September 2018 / Published: 19 September 2018
PDF Full-text (2544 KB) | HTML Full-text | XML Full-text
Abstract
Greige cotton (unbleached cotton) is an intact plant fiber that retains much of the outer cotton fiber layers. These layers contain pectin, peroxidases, and trace metals that are associated with hydrogen peroxide (H2O2) generation during cotton fiber development. When
[...] Read more.
Greige cotton (unbleached cotton) is an intact plant fiber that retains much of the outer cotton fiber layers. These layers contain pectin, peroxidases, and trace metals that are associated with hydrogen peroxide (H2O2) generation during cotton fiber development. When greige cotton is subjected to a nonwoven hydroentanglement process, components of the outer cotton fiber layers are retained. When hydrated, this fabric can generate H2O2 (5–50 micromolar). This range has been characterized as inducing accelerated wound healing associated with enhanced cell signaling and the proliferation of cells vital to wound restoration. On the other hand, H2O2 levels above 50 micromolar have been associated with bacteriostatic activity. Here, we report the preparation and hydrogen peroxide activity of copper/ascorbate formulations, both as adsorbed and in situ synthesized analogs on cotton. The cooper/ascorbate-cotton formulations were designed with the goal of modulating hydrogen peroxide levels within functional ranges beneficial to wound healing. The cotton/copper formulation analogs were prepared on nonwoven unbleached cotton and characterized with cotton impregnation titers of 3–14 mg copper per gram of cotton. The copper/ascorbate cotton analog formulations were characterized spectroscopically, and the copper titer was quantified with ICP analysis and probed for peroxide production through assessment with Amplex Red. All analogs demonstrated antibacterial activity. Notably, the treatment of unbleached cotton with low levels of ascorbate (~2 mg/g cotton) resulted in a 99 percent reduction in Klebsiella pneumoniae and Staphylococcus aureus. In situ synthesized copper/ascorbate nanoparticles retained activity and did not leach out upon prolonged suspension in an aqueous environment. An assessment of H2O2 effects on fibroblast proliferation are discussed in light of the copper/cotton analogs and wound healing. Full article
(This article belongs to the Special Issue Recent Advances in Antimicrobial Biomaterials)
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Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Author: Imran Rahim
Planned Title: Pseudomonas aeruginosa biofilm formation on magnesium implants and antibiotic resistance are dependent on inoculum.
Short abstract: Evaluation of novel antimicrobial strategies against biofilm infections requires characterization of infection dynamics. Previously established, here we investigate P. aeruginosa infection kinetics on magnesium implants to evaluate the efficacy of antimicrobials treatment. P. aeruginosa suspensions were injected at escalating infectious doses. Sequential in vivo imaging results revealed that the observed spatiotemporal kinetics of P. aeruginosa biofilms was dramatically influenced by the initial infectious dose. Antibiotic therapy success was inversely correlated to initial infectious dose. We posit that achieving a high density of suspended bacterial cells in the course of implant infections could play an essential role to establish long term survival.
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