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Special Issue "EGCG, Green Tea and Polyphenols"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 December 2019

Special Issue Editors

Guest Editor
Dr. Helieh S. Oz

University of Kentucky Medical Center, Lexington, KY, USA
Website | E-Mail
Interests: inflammatory and infectious diseases; nutrients; antioxidants; reactive oxygen radical; gastrointestinal inflammation; inflammatory bowel disease; microbial; parasitic and fungal infectious diseases; hepatic; pancreatic complication; models of infections and inflammation; nutraceutical and therapeutic discoveries
Guest Editor
Dr. Veeranoot Nissapatorn

School of Allied Health Sciences, Walailak University, Thailand
Website | E-Mail
Interests: infectious parasitic diseases; epidemiology; clinical relevant; diagnostic challenges

Special Issue Information

Dear Colleagues,

Green tea is extracted from shrub, Camellia sinensis, leaves and is consumed as one of the most common beverages around the world. Green tea and its main polyphenolic component, epigalloccatechin-3-gallate (EGCG), are known to have putative health effects, such as antioxidant, anti-inflammatory, antmicrobial, and anti-carcinogenic properties. In addition, EGCG and other polyphenols are known to modulate nuclear factor kappa B (NF-kB), IKK activity and to inhibit inflammatory markers (e.g., TNFα, IL-6) and bioenzymes (e.g., myeloperoxidase). Green tea and polyphenols are believed to support microbiome and gut health. In addition, tea compounds are used in cosmetics and implemented as natural food preservative.

This Special Issue aims to identify and review the latest bioactive compounds from tea and polyphenols to have beneficial effects in body. Authors are invited to submit relevant papers on novel activities of green tea, polyphenols including EGCG activities, and strategies to support or to depose beneficial effect on inflammatory, microbial, viral, and antioxidants measurements. Moreover, discoveries of the mechanism of actions by which tea and its polyphenols may support the microbiome and gut health to prevent inflammatory complications are of particular interest. Basic, pilot clinical and translational and retrospective trials, as well as review articles in this area are of interest.

Dr. Helieh S. Oz
Assoc. Prof. Dr. Veeranoot Nissapatorn
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green tea
  • EGCG
  • polyphenols
  • mechanism of action

Published Papers (5 papers)

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Research

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Open AccessArticle
The Association between Green and Black Tea Consumption on Successful Aging: A Combined Analysis of the ATTICA and MEDiterranean ISlands (MEDIS) Epidemiological Studies
Molecules 2019, 24(10), 1862; https://doi.org/10.3390/molecules24101862
Received: 11 April 2019 / Revised: 9 May 2019 / Accepted: 14 May 2019 / Published: 15 May 2019
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Abstract
Tea is one of the most-widely consumed beverages in the world with a number of different beneficial health effects, mainly ascribed to the polyphenolic content of the tea catechins. The aim of this study was to examine the consumption of green, black, or [...] Read more.
Tea is one of the most-widely consumed beverages in the world with a number of different beneficial health effects, mainly ascribed to the polyphenolic content of the tea catechins. The aim of this study was to examine the consumption of green, black, or no tea, in relation to the previously validated successful ageing index (SAI; higher values “healthier” ageing) in a combined analysis of adults aged >50 years old from the ATTICA (n = 1128 adults from Athens, Greece metropolitan area) and the MEDiterranean Islands Study (MEDIS) (n = 2221 adults from various Greek island and Mani) studies. After adjusting for age, sex, smoking, and coffee consumption, green tea was positively associated with SAI (b ± SE: 0.225 ± 0.055, p < 0.001), while black tea was negatively associated with SAI (unstandardized b coefficient ± Standard error: −0.807 ± 0.054, p < 0.001). Green tea (vs black tea) consumption, had higher odds of a SAI of over 3.58 out of 10 (OR: 1.77, 95% CI: 1.38–2.28). Green tea consumption was also associated with higher levels of physical activity (p < 0.001) and reduced likelihood of hypertension (p = 0.006) compared with black tea. Two possible mechanisms are that green tea possesses high levels of catechins such as (−)-epigallocatechin 3-gallate and l-theanine compared with black tea. Therefore, the present analysis supports both the role of green tea constituents in successful ageing, as well as its role as an important component of an overall healthy diet in adults aged 50 years and over from these two epidemiological studies. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Open AccessArticle
In Silico Investigation of the Anti-Tumor Mechanisms of Epigallocatechin-3-Gallate
Molecules 2019, 24(7), 1445; https://doi.org/10.3390/molecules24071445
Received: 6 March 2019 / Revised: 6 April 2019 / Accepted: 9 April 2019 / Published: 11 April 2019
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Abstract
The EGCG, an important component of polyphenol in green tea, is well known due to its numerous health benefits. We employed the reverse docking method for the identification of the putative targets of EGCG in the anti-tumor target protein database and these targets [...] Read more.
The EGCG, an important component of polyphenol in green tea, is well known due to its numerous health benefits. We employed the reverse docking method for the identification of the putative targets of EGCG in the anti-tumor target protein database and these targets were further uploaded to public databases in order to understand the underlying pharmacological mechanisms and search for novel EGCG-associated targets. Similarly, the pharmacological linkage between tumor-related proteins and EGCG was manually constructed in order to provide greater insight into the molecular mechanisms through a systematic integration with applicable bioinformatics. The results indicated that the anti-tumor mechanisms of EGCG may involve 12 signaling transduction pathways and 33 vital target proteins. Moreover, we also discovered four novel putative target proteins of EGCG, including IKBKB, KRAS, WEE1 and NTRK1, which are significantly related to tumorigenesis. In conclusion, this work may provide a useful perspective that will improve our understanding of the pharmacological mechanism of EGCG and identify novel potential therapeutic targets. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Review

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Open AccessReview
Antimicrobial Activities of Tea Polyphenol on Phytopathogens: A Review
Molecules 2019, 24(4), 816; https://doi.org/10.3390/molecules24040816
Received: 29 January 2019 / Revised: 22 February 2019 / Accepted: 23 February 2019 / Published: 25 February 2019
Cited by 1 | PDF Full-text (875 KB) | HTML Full-text | XML Full-text
Abstract
The use of natural antimicrobial compounds in crop production has gained much attention from consumers and the agricultural industry. Consequently, interest in more natural, non-synthetic antimicrobials as potential alternatives to conventional chemical pesticides to combat phytopathogens has heightened. Tea polyphenol (TP), a unique [...] Read more.
The use of natural antimicrobial compounds in crop production has gained much attention from consumers and the agricultural industry. Consequently, interest in more natural, non-synthetic antimicrobials as potential alternatives to conventional chemical pesticides to combat phytopathogens has heightened. Tea polyphenol (TP), a unique and highly important functional component of tea plants, has been reported to possess antimicrobial properties against a wide spectrum of plant pathogens. The aim of this review is to discuss the emerging findings on the mechanisms of antimicrobial action, and the antimicrobial properties of TP, including their major components, effectiveness, and synergistic effects. More studies, particularly field studies, are still necessary to establish conclusive evidence for the effectiveness of TP against phytopathogens. However, the basic conclusion from existing studies suggests that TP is a potential antimicrobial agent for pesticide reduction in agricultural systems. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Open AccessReview
Bioavailability of Tea Catechins and Its Improvement
Molecules 2018, 23(9), 2346; https://doi.org/10.3390/molecules23092346
Received: 3 August 2018 / Revised: 2 September 2018 / Accepted: 12 September 2018 / Published: 13 September 2018
Cited by 4 | PDF Full-text (1011 KB) | HTML Full-text | XML Full-text
Abstract
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading [...] Read more.
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading to these inconsistencies. Research advances in bioavailability studies involving absorption and metabolic biotransformation of tea catechins were reviewed in the present paper. Related techniques for improving their bioavailability such as nanostructure-based drug delivery system, molecular modification, and co-administration of catechins with other bioactives were also discussed. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Open AccessReview
Suppressive Effects of EGCG on Cervical Cancer
Molecules 2018, 23(9), 2334; https://doi.org/10.3390/molecules23092334
Received: 9 August 2018 / Revised: 5 September 2018 / Accepted: 11 September 2018 / Published: 12 September 2018
Cited by 6 | PDF Full-text (880 KB) | HTML Full-text | XML Full-text
Abstract
Cervical cancer is the fourth most common gynecological cancer worldwide. Although prophylactic vaccination presents the most effective method for cervical cancer prevention, chemotherapy is still the primary invasive intervention. It is urgent to exploit low-toxic natural anticancer drugs on account of high cytotoxicity [...] Read more.
Cervical cancer is the fourth most common gynecological cancer worldwide. Although prophylactic vaccination presents the most effective method for cervical cancer prevention, chemotherapy is still the primary invasive intervention. It is urgent to exploit low-toxic natural anticancer drugs on account of high cytotoxicity and side-effects of conventional agents. As a natural product, (-)-epigallocatechingallate (EGCG) has abilities in anti-proliferation, anti-metastasis and pro-apoptosis of cervical cancer cells. Moreover, EGCG also has pharmaceutical synergistic effects with conventional agents such as cisplatin (CDDP) and bleomycin (BLM). The underlying mechanisms of EGCG suppressive effects on cervical cancer are reviewed in this article. Further research directions and ambiguous results are also discussed. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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