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Special Issue "EGCG, Green Tea and Polyphenols"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2019).

Special Issue Editors

Dr. Helieh S. Oz
E-Mail Website
Guest Editor
University of Kentucky Medical Center, Lexington, KY, USA
Interests: inflammatory and infectious diseases; nutrients; antioxidants; reactive oxygen radical; gastrointestinal inflammation; inflammatory bowel disease; microbial; parasitic and fungal infectious diseases; hepatic; pancreatic complication; models of infections and inflammation; nutraceutical and therapeutic discoveries
Special Issues and Collections in MDPI journals
Dr. Veeranoot Nissapatorn
E-Mail Website
Guest Editor
School of Allied Health Sciences, Walailak University, Thailand
Interests: infectious parasitic diseases; epidemiology; clinical relevant; diagnostic challenges

Special Issue Information

Dear Colleagues,

Green tea is extracted from shrub, Camellia sinensis, leaves and is consumed as one of the most common beverages around the world. Green tea and its main polyphenolic component, epigalloccatechin-3-gallate (EGCG), are known to have putative health effects, such as antioxidant, anti-inflammatory, antmicrobial, and anti-carcinogenic properties. In addition, EGCG and other polyphenols are known to modulate nuclear factor kappa B (NF-kB), IKK activity and to inhibit inflammatory markers (e.g., TNFα, IL-6) and bioenzymes (e.g., myeloperoxidase). Green tea and polyphenols are believed to support microbiome and gut health. In addition, tea compounds are used in cosmetics and implemented as natural food preservative.

This Special Issue aims to identify and review the latest bioactive compounds from tea and polyphenols to have beneficial effects in body. Authors are invited to submit relevant papers on novel activities of green tea, polyphenols including EGCG activities, and strategies to support or to depose beneficial effect on inflammatory, microbial, viral, and antioxidants measurements. Moreover, discoveries of the mechanism of actions by which tea and its polyphenols may support the microbiome and gut health to prevent inflammatory complications are of particular interest. Basic, pilot clinical and translational and retrospective trials, as well as review articles in this area are of interest.

Dr. Helieh S. Oz
Assoc. Prof. Dr. Veeranoot Nissapatorn
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green tea
  • EGCG
  • polyphenols
  • mechanism of action

Published Papers (7 papers)

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Research

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Article
RNA-seq Based Transcriptome Analysis of the Anti-Obesity Effect of Green Tea Extract Using Zebrafish Obesity Models
Molecules 2019, 24(18), 3256; https://doi.org/10.3390/molecules24183256 - 06 Sep 2019
Cited by 8 | Viewed by 1840
Abstract
Green tea is a popular beverage that is rich in polyphenolic compounds such as catechins. Its major content, (-)-epigallocatechin-3-gallate, has been shown to have beneficial effects on several diseases including cancer, metabolic syndrome, cardiovascular diseases, and neurodegenerative diseases. The aim of this study [...] Read more.
Green tea is a popular beverage that is rich in polyphenolic compounds such as catechins. Its major content, (-)-epigallocatechin-3-gallate, has been shown to have beneficial effects on several diseases including cancer, metabolic syndrome, cardiovascular diseases, and neurodegenerative diseases. The aim of this study was to assess the anti-obesity effects and the underlying molecular mechanisms of green tea extract (GTE) using zebrafish larva and adult obesity models. We administered 100 μg/mL GTE to zebrafish larvae and performed a short-term obesogenic test. GTE significantly decreased the visceral adipose tissue volume induced by a high-fat diet. Oral administration (250 µg/g body weight/day) of GTE to adult diet-induced obese zebrafish also significantly reduced their visceral adipose tissue volume, with a reduction of plasma triglyceride and total cholesterol levels. To investigate the molecular mechanism underlying the GTE effects, we conducted RNA sequencing using liver tissues of adult zebrafish and found that GTE may ameliorate the obese phenotypes via the activation of Wnt/β-catenin and adenosine monophosphate-activated protein kinase (AMPK) pathway signaling. In addition, the comparative transcriptome analysis revealed that zebrafish and mammals may share a common molecular response to GTE. Our findings suggest that daily consumption of green tea may be beneficial for the prevention and treatment of obesity. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Article
The Association between Green and Black Tea Consumption on Successful Aging: A Combined Analysis of the ATTICA and MEDiterranean ISlands (MEDIS) Epidemiological Studies
Molecules 2019, 24(10), 1862; https://doi.org/10.3390/molecules24101862 - 15 May 2019
Cited by 11 | Viewed by 3677
Abstract
Tea is one of the most-widely consumed beverages in the world with a number of different beneficial health effects, mainly ascribed to the polyphenolic content of the tea catechins. The aim of this study was to examine the consumption of green, black, or [...] Read more.
Tea is one of the most-widely consumed beverages in the world with a number of different beneficial health effects, mainly ascribed to the polyphenolic content of the tea catechins. The aim of this study was to examine the consumption of green, black, or no tea, in relation to the previously validated successful ageing index (SAI; higher values “healthier” ageing) in a combined analysis of adults aged >50 years old from the ATTICA (n = 1128 adults from Athens, Greece metropolitan area) and the MEDiterranean Islands Study (MEDIS) (n = 2221 adults from various Greek island and Mani) studies. After adjusting for age, sex, smoking, and coffee consumption, green tea was positively associated with SAI (b ± SE: 0.225 ± 0.055, p < 0.001), while black tea was negatively associated with SAI (unstandardized b coefficient ± Standard error: −0.807 ± 0.054, p < 0.001). Green tea (vs black tea) consumption, had higher odds of a SAI of over 3.58 out of 10 (OR: 1.77, 95% CI: 1.38–2.28). Green tea consumption was also associated with higher levels of physical activity (p < 0.001) and reduced likelihood of hypertension (p = 0.006) compared with black tea. Two possible mechanisms are that green tea possesses high levels of catechins such as (−)-epigallocatechin 3-gallate and l-theanine compared with black tea. Therefore, the present analysis supports both the role of green tea constituents in successful ageing, as well as its role as an important component of an overall healthy diet in adults aged 50 years and over from these two epidemiological studies. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Article
In Silico Investigation of the Anti-Tumor Mechanisms of Epigallocatechin-3-Gallate
Molecules 2019, 24(7), 1445; https://doi.org/10.3390/molecules24071445 - 11 Apr 2019
Cited by 9 | Viewed by 1778
Abstract
The EGCG, an important component of polyphenol in green tea, is well known due to its numerous health benefits. We employed the reverse docking method for the identification of the putative targets of EGCG in the anti-tumor target protein database and these targets [...] Read more.
The EGCG, an important component of polyphenol in green tea, is well known due to its numerous health benefits. We employed the reverse docking method for the identification of the putative targets of EGCG in the anti-tumor target protein database and these targets were further uploaded to public databases in order to understand the underlying pharmacological mechanisms and search for novel EGCG-associated targets. Similarly, the pharmacological linkage between tumor-related proteins and EGCG was manually constructed in order to provide greater insight into the molecular mechanisms through a systematic integration with applicable bioinformatics. The results indicated that the anti-tumor mechanisms of EGCG may involve 12 signaling transduction pathways and 33 vital target proteins. Moreover, we also discovered four novel putative target proteins of EGCG, including IKBKB, KRAS, WEE1 and NTRK1, which are significantly related to tumorigenesis. In conclusion, this work may provide a useful perspective that will improve our understanding of the pharmacological mechanism of EGCG and identify novel potential therapeutic targets. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Review

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Review
Targeting Bacterial Biofilms by the Green Tea Polyphenol EGCG
Molecules 2019, 24(13), 2403; https://doi.org/10.3390/molecules24132403 - 29 Jun 2019
Cited by 28 | Viewed by 2675
Abstract
Bacterial biofilms are multicellular aggregates in which cells are embedded in an extracellular matrix of self-produced biopolymers. Being refractory to antibiotic treatment and host immune systems, biofilms are involved in most chronic infections, and anti-biofilm agents are being searched for urgently. Epigallocatechin-3-gallate (EGCG) [...] Read more.
Bacterial biofilms are multicellular aggregates in which cells are embedded in an extracellular matrix of self-produced biopolymers. Being refractory to antibiotic treatment and host immune systems, biofilms are involved in most chronic infections, and anti-biofilm agents are being searched for urgently. Epigallocatechin-3-gallate (EGCG) was recently shown to act against biofilms by strongly interfering with the assembly of amyloid fibres and the production of phosphoethanolamin-modified cellulose fibrils. Mechanistically, this includes a direct inhibition of the fibre assembly, but also triggers a cell envelope stress response that down-regulates the synthesis of these widely occurring biofilm matrix polymers. Based on its anti-amyloidogenic properties, EGCG seems useful against biofilms involved in cariogenesis or chronic wound infection. However, EGCG seems inefficient against or may even sometimes promote biofilms which rely on other types of matrix polymers, suggesting that searching for ‘magic bullet’ anti-biofilm agents is an unrealistic goal. Combining molecular and ecophysiological aspects in this review also illustrates why plants control the formation of biofilms on their surfaces by producing anti-amyloidogenic compounds such as EGCG. These agents are not only helpful in combating certain biofilms in chronic infections but even seem effective against the toxic amyloids associated with neuropathological diseases. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Review
Antimicrobial Activities of Tea Polyphenol on Phytopathogens: A Review
Molecules 2019, 24(4), 816; https://doi.org/10.3390/molecules24040816 - 25 Feb 2019
Cited by 19 | Viewed by 2031
Abstract
The use of natural antimicrobial compounds in crop production has gained much attention from consumers and the agricultural industry. Consequently, interest in more natural, non-synthetic antimicrobials as potential alternatives to conventional chemical pesticides to combat phytopathogens has heightened. Tea polyphenol (TP), a unique [...] Read more.
The use of natural antimicrobial compounds in crop production has gained much attention from consumers and the agricultural industry. Consequently, interest in more natural, non-synthetic antimicrobials as potential alternatives to conventional chemical pesticides to combat phytopathogens has heightened. Tea polyphenol (TP), a unique and highly important functional component of tea plants, has been reported to possess antimicrobial properties against a wide spectrum of plant pathogens. The aim of this review is to discuss the emerging findings on the mechanisms of antimicrobial action, and the antimicrobial properties of TP, including their major components, effectiveness, and synergistic effects. More studies, particularly field studies, are still necessary to establish conclusive evidence for the effectiveness of TP against phytopathogens. However, the basic conclusion from existing studies suggests that TP is a potential antimicrobial agent for pesticide reduction in agricultural systems. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Review
Bioavailability of Tea Catechins and Its Improvement
Molecules 2018, 23(9), 2346; https://doi.org/10.3390/molecules23092346 - 13 Sep 2018
Cited by 77 | Viewed by 3652
Abstract
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading [...] Read more.
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading to these inconsistencies. Research advances in bioavailability studies involving absorption and metabolic biotransformation of tea catechins were reviewed in the present paper. Related techniques for improving their bioavailability such as nanostructure-based drug delivery system, molecular modification, and co-administration of catechins with other bioactives were also discussed. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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Review
Suppressive Effects of EGCG on Cervical Cancer
Molecules 2018, 23(9), 2334; https://doi.org/10.3390/molecules23092334 - 12 Sep 2018
Cited by 30 | Viewed by 2576
Abstract
Cervical cancer is the fourth most common gynecological cancer worldwide. Although prophylactic vaccination presents the most effective method for cervical cancer prevention, chemotherapy is still the primary invasive intervention. It is urgent to exploit low-toxic natural anticancer drugs on account of high cytotoxicity [...] Read more.
Cervical cancer is the fourth most common gynecological cancer worldwide. Although prophylactic vaccination presents the most effective method for cervical cancer prevention, chemotherapy is still the primary invasive intervention. It is urgent to exploit low-toxic natural anticancer drugs on account of high cytotoxicity and side-effects of conventional agents. As a natural product, (-)-epigallocatechingallate (EGCG) has abilities in anti-proliferation, anti-metastasis and pro-apoptosis of cervical cancer cells. Moreover, EGCG also has pharmaceutical synergistic effects with conventional agents such as cisplatin (CDDP) and bleomycin (BLM). The underlying mechanisms of EGCG suppressive effects on cervical cancer are reviewed in this article. Further research directions and ambiguous results are also discussed. Full article
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
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