Frontiers in Metal-Catalysed Cross-Coupling Reactions for the Synthesis and Functionalisation of Heterocycles

Dear Colleagues,

Transition metal-catalyzed cross-coupling reactions are of paramount importance in organic synthesis. Over the past 30 years, metal-catalyzed C−X (X = C, N, O, S, etc.) bond formation reactions received considerable attention due to their convenience and efficiency. These methods have profoundly changed the protocols for the construction of natural products, building blocks for supramolecular chemistry and self-assembly, pharmaceuticals, agrochemicals, and advanced materials on both laboratory and industrial scales.

Nowadays, transition metal-catalysed cross-coupling reactions constitute an important tool for the synthesis and functionalization of several types of heterocyclic compounds, but the field is still wide-open for innovation and will continue to advance as even more versatile transformations are developed. For instance, multicomponent reactions have been used for the synthesis of heterocycles and many strategies have been developed for the construction of highly functionalized heterocycles, but there are also works focused on the direct functionalization of heteroaromatic compounds.

The present Special Issue intends to highlight updated contributions in the construction and functionalisation of heterocyclic compounds and derivatives involving transition metal-catalyzed cross-coupling reactions as the key step. Reviews articles by experts in the field will also be welcome.

Prof. Dr. Artur M. S. Silva
Dr. Maria Manuel Marques
Guest Editors

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