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Molecules 2019, 24(4), 687; https://doi.org/10.3390/molecules24040687

Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract

1
Sinphar Pharmaceutical Co., Ltd., Sinphar Group, Yilan 269, Taiwan
2
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
3
School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan
4
Sinphar Tian-Li Pharmaceutical Co., Ltd., Sinphar Group, Hangzhou 311100, China
*
Authors to whom correspondence should be addressed.
Received: 17 January 2019 / Revised: 13 February 2019 / Accepted: 13 February 2019 / Published: 14 February 2019
(This article belongs to the Special Issue The Potential Use of Herbal Medicinal Products in Chronic Disorders)
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Abstract

Cistanche tubulosa aqueous extract (CTE) is already used as a botanical prescription drug for treating dementia in China. Our previous studies reported that phenylethanoid glycosides of CTE have anti-Alzheimer’s disease (AD) activity by inhibiting amyloid β peptide (Aβ) aggregation and deposition. However, recent studies considered that the phenylethanoid glycosides may be metabolized by intestinal bacteria, because all analysis results showed that the bioavailability of phenylethanoid glycosides is extremely low. In this study we demonstrate how iron chelation plays a crucial role in the Aβ aggregation and deposition inhibition mechanism of phenylethanoid glycosides of CTE. In addition, we further proved phenylethanoid glycosides (13) could reach brain. Active CTE component and action mechanism confirmation will be a great help for product quality control and bioavailability studies in the future. At the same time, we provide a new analysis method useful in determining phenylethanoid glycosides (13) in plants, foods, blood, and tissues for chemical fingerprint and pharmacokinetic research. View Full-Text
Keywords: Cistanche tubulosa; phenylethanoid glycosides; Alzheimer’s disease; iron chelation Cistanche tubulosa; phenylethanoid glycosides; Alzheimer’s disease; iron chelation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chao, C.-L.; Huang, H.-W.; Huang, H.-C.; Chao, H.-F.; Yu, S.-W.; Su, M.-H.; Wang, C.-J.; Lin, H.-C. Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract. Molecules 2019, 24, 687.

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