Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract
AbstractCistanche tubulosa aqueous extract (CTE) is already used as a botanical prescription drug for treating dementia in China. Our previous studies reported that phenylethanoid glycosides of CTE have anti-Alzheimer’s disease (AD) activity by inhibiting amyloid β peptide (Aβ) aggregation and deposition. However, recent studies considered that the phenylethanoid glycosides may be metabolized by intestinal bacteria, because all analysis results showed that the bioavailability of phenylethanoid glycosides is extremely low. In this study we demonstrate how iron chelation plays a crucial role in the Aβ aggregation and deposition inhibition mechanism of phenylethanoid glycosides of CTE. In addition, we further proved phenylethanoid glycosides (1–3) could reach brain. Active CTE component and action mechanism confirmation will be a great help for product quality control and bioavailability studies in the future. At the same time, we provide a new analysis method useful in determining phenylethanoid glycosides (1–3) in plants, foods, blood, and tissues for chemical fingerprint and pharmacokinetic research. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 2095 KB)
Share & Cite This Article
Chao, C.-L.; Huang, H.-W.; Huang, H.-C.; Chao, H.-F.; Yu, S.-W.; Su, M.-H.; Wang, C.-J.; Lin, H.-C. Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract. Molecules 2019, 24, 687.
Chao C-L, Huang H-W, Huang H-C, Chao H-F, Yu S-W, Su M-H, Wang C-J, Lin H-C. Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract. Molecules. 2019; 24(4):687.Chicago/Turabian Style
Chao, Chien-Liang; Huang, Hsin-Wen; Huang, Hui-Chi; Chao, Hsin-Fan; Yu, Shuen-Wen; Su, Muh-Hwan; Wang, Chao-Jih; Lin, Hang-Ching. 2019. "Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract." Molecules 24, no. 4: 687.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.