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Molecules, Volume 24, Issue 5

March-1 2019 - 176 articles

Cover Story: The race to develop glycosaminoglycan (GAG) mimetics as the drug of choice for ailments ranging from cancer to inflammation is heating up. The development of any new drug class, however, comes with challenges. Moving from animal models to clinical trials is an important step, and, often, the preclinical data do not translate well to the clinical setting. Increasingly, it is being understood that the choice of animal species used in preclinical testing is of critical importance. For GAG mimetics, making an informed choice has been difficult. However, we are now proposing a method based on a range of comparative modelling techniques that will transform this process. The application of our method should lead to data that better translate to the clinical stages, and, hence, reduce the risks of moving from preclinical to clinical trials. View this paper.
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Articles (176)

  • Article
  • Open Access
48 Citations
5,985 Views
10 Pages

Dietary Fiber from Chickpea (Cicer arietinum) and Soybean (Glycine max) Husk Byproducts as Baking Additives: Functional and Nutritional Properties

  • Guillermo Niño-Medina,
  • Dolores Muy-Rangel,
  • Ana Laura de la Garza,
  • Werner Rubio-Carrasco,
  • Briceida Pérez-Meza,
  • Ana P. Araujo-Chapa,
  • Kelsy A. Gutiérrez-Álvarez and
  • Vania Urías-Orona

Dietary fiber extracted from soybean and chickpea husks was used in the formulation of white bread. Treatments at different concentrations of dietary fiber (DF): bread + 0.15%, 0.3%, 1.5%, 2% soybean dietary fiber (SDF); bread + 0.15%, 0.3%, 1.5%, 2%...

  • Article
  • Open Access
11 Citations
3,956 Views
12 Pages

Photo-Reduction of CO2 by VIS Light on Polythiophene-ZSM-5 Zeolite Hybrid Photo-Catalyst

  • Jana Kianička,
  • Gabriel Čík,
  • František Šeršeň,
  • Ivan Špánik,
  • Robert Sokolík and
  • Juraj Filo

A new hybrid photo-catalyst based on ZSM-5 zeolite suitable for reduction of carbon dioxide was synthesized. The photo-catalyst was prepared by oxidative polymerization of thiophene with FeCl3 in the presence of ZSM-5 with participation of ultrasound...

  • Article
  • Open Access
11 Citations
4,637 Views
14 Pages

Differential Proteomics Reveals miR-155 as a Novel Indicator of Liver and Spleen Pathology in the Symptomatic Niemann-Pick Disease, Type C1 Mouse Model

  • Melissa R. Pergande,
  • Antony Cougnoux,
  • Rathnayake A. C. Rathnayake,
  • Forbes D. Porter and
  • Stephanie M. Cologna

Niemann-Pick disease, type C1 (NPC1) is a rare, autosomal recessive, lipid storage disorder caused by mutations in NPC1. As a result, there is accumulation of unesterified cholesterol and sphingolipids in the late endosomal/lysosomal system. Clinical...

  • Article
  • Open Access
13 Citations
4,876 Views
25 Pages

Antrodin C, an NADPH Dependent Metabolism, Encourages Crosstalk between Autophagy and Apoptosis in Lung Carcinoma Cells by Use of an AMPK Inhibition-Independent Blockade of the Akt/mTOR Pathway

  • Hairui Yang,
  • Xu Bai,
  • Henan Zhang,
  • Jingsong Zhang,
  • Yingying Wu,
  • Chuanhong Tang,
  • Yanfang Liu,
  • Yan Yang,
  • Zhendong Liu and
  • Wei Jia
  • + 1 author

The current study aims to explore the possible anti-lung carcinoma activity of ADC as well as the underlying mechanisms by which ADC exerts its actions in NSCLC. Findings showed that ADC potently inhibited the viability of SPCA-1, induced apoptosis t...

  • Review
  • Open Access
61 Citations
8,992 Views
14 Pages

Capsazepine is a synthetic analogue of capsaicin that can function as an antagonist of TRPV1. Capsazepine can exhibit diverse effects on cancer (prostate cancer, breast cancer, colorectal cancer, oral cancer, and osteosarcoma) growth and survival, an...

  • Article
  • Open Access
7 Citations
5,358 Views
16 Pages

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

  • Ohm Prakash,
  • Jana Führing,
  • John Post,
  • Sharon M. Shepherd,
  • Thomas C. Eadsforth,
  • David Gray,
  • Roman Fedorov and
  • Françoise H. Routier

Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide. The antileishmanial therapeutic arsenal remains very limited in number and efficacy,...

  • Article
  • Open Access
3 Citations
4,474 Views
11 Pages

The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy

  • Bo Wang,
  • Liping Wang,
  • Ying Peng,
  • Yiying Pang,
  • Hesheng Xiao,
  • Xiaoji Wang and
  • Shuangping Huang

Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of mu...

  • Article
  • Open Access
4 Citations
5,051 Views
11 Pages

Oligonucleotide Binding to Non-B-DNA in MYC

  • Tea Umek,
  • Karin Sollander,
  • Helen Bergquist,
  • Jesper Wengel,
  • Karin E. Lundin,
  • C.I. Edvard Smith and
  • Rula Zain

12 March 2019

MYC, originally named c-myc, is an oncogene deregulated in many different forms of cancer. Translocation of the MYC gene to an immunoglobulin gene leads to an overexpression and the development of Burkitt’s lymphoma (BL). Sporadic BL constitute...

  • Article
  • Open Access
6 Citations
4,326 Views
18 Pages

Sea cucumber (Apostichopus japonicus) is an economically significant species in China having great commercial value. It is challenging to maintain the textural properties during thermal processing due to the distinctive physiochemical structure of th...

  • Review
  • Open Access
109 Citations
25,910 Views
20 Pages

Novel Therapeutics for Epstein–Barr Virus

  • Graciela Andrei,
  • Erika Trompet and
  • Robert Snoeck

Epstein–Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult population. Primary EBV infection usually occurs during childhood and is generally asymptomatic, though the virus can cause infectious mononucleosis in...

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Molecules - ISSN 1420-3049Creative Common CC BY license