Molecules, Volume 24, Issue 5 (March-1 2019) – 176 articles
Cover Story (view full-size image): The race to develop glycosaminoglycan (GAG) mimetics as the drug of choice for ailments ranging from cancer to inflammation is heating up. The development of any new drug class, however, comes with challenges. Moving from animal models to clinical trials is an important step, and, often, the preclinical data do not translate well to the clinical setting. Increasingly, it is being understood that the choice of animal species used in preclinical testing is of critical importance. For GAG mimetics, making an informed choice has been difficult. However, we are now proposing a method based on a range of comparative modelling techniques that will transform this process. The application of our method should lead to data that better translate to the clinical stages, and, hence, reduce the risks of moving from preclinical to clinical trials. View this paper.
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