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Special Issue "Molecular Tools for Nucleic Acid Manipulation for Biological Intervention"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 January 2019).
Department of Biosciences and Nutrition, Karolinska Institute, NEO, 14157 Huddinge, Sweden
Interests: nucleic acid chemistry; oligonucleotides; peptides; oligonucleotide conjugates; oligonucleotide therapy; peptide conjugates; artificial nucleases; antimicrobial peptides; RNA therapy; gene therapy; affectors of innate immunity; treatment of infectious disease, degenerate disease, muscular dystrophy and cancer
Manipulation of nucleic acids and their activities has become indispensable in molecular biology and medicine. In addition, such manipulation is also the basis for emerging disease therapies, not least proven by recent FDA approvals of oligonucleotide therapy applications. The need for new developments in the field is crucial in order to obtain tools or therapeutics that are more efficient, selective or allow novel approaches, investigations or disease treatments. Here, chemistry will play a crucial role both in the understanding of mechanisms or in development of novel modifications, conjugates tools, etc.
This Special Issue of Molecules is intended to encompass contributions from various approaches to influence biological action of nucleic acids, with a focus on chemistry. This includes methods for making, and studies on the action of modified oligonucleotides (ONs), ON conjugates and cleavers of phosphodiester bonds. The latter includes artificial (also oligonucleotide and peptide nucleic acid based ones) or modified nucleases and other phosphate ester transferring enzymes and nanoparticle based cleavers. In addition, delivery systems for ONs, as well as ON conjugates aimed at cell, tissue or subcellular delivery are a part of the topic.
Prof. Dr. Roger Strömberg
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oligonucleotide therapy
- oligonucleotide conjugates
- artificial nucleases
- peptide conjugates
- cellular uptake
- drug delivery