Special Issue "Natural Toxins/Molecules (and Derivatives) from Animal Venoms: From Basic Research to Therapeutic Applications"
Deadline for manuscript submissions: 1 October 2018
Dr. Jean-Marc Sabatier
Laboratory INSERM UMR 1097, Aix-Marseille University, 163, Parc Scientifique et Technologique de Luminy, Avenue de Luminy, Bâtiment TPR2, Case 939, Marseille 13288, France
Interests: chemical synthesis; peptide synthesis; structure-activity relationships; medicinal chemistry; candidate drugs; antivirals, antibacterials; antioxidants; toxins
Venomous animals (e.g., scorpions, snakes, sea anemones, cone snails, worms, wasps and frogs) are invaluable natural sources of biologically-active compounds that target a variety of receptors/molecules (ion channels, enzymes, etc.). These compounds are generally highly potent, but can display variable selectivities. Interestingly, a number of molecules from venoms reportedly possess some therapeutic potential to treat pain, microbial infections, and more or less severe pathologies such as cancer, autoimmune and neurological diseases. This special issue of ‘Molecules’ is devoted to the many aspects of marine and non-marine toxins/molecules (and derivatives thereof) from animal venoms, including their pharmacological properties, structural characteristics, structure-function relationship, molecular engineering/drug design, and therapeutic value. All scientists and clinicians working in these emerging and promising fields of research are strongly encouraged to submit their original works for publication in this Special Issue.Dr. Jean-Marc Sabatier
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- animal toxin
- venomous animal
- toxin engineering
- drug design
- chemotherapeutic drug
- ion channel
- autoimmune disease
- neurological disorder
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Response of Cellular Immunity to Cnidarian Pore-Forming Toxins
A group of stable, water-soluble and membrane-bound proteins constitute the pore forming toxins (PFTs) in cnidarians. They interact with membranes to physically alter the membrane structure and permeability, resulting in the formation of pores. These lesions on the plasma membrane causes an imbalance of cellular ionic gradients, resulting in swelling of the cell and eventually its rupture. Of all cnidarian PFTs, actinoporins are by far the best studied subgroup with established knowledge in their molecular structure and their mode of pore-forming action. However, the current view of necrotic action by actinoporins may not be the only mechanism that induces cell death since there are increasing evidence showing that pore-forming toxins can induce either necrosis or apoptosis in a cell-type and dose-dependent manner. In this review, we focus on the response of cellular immunity to the cnidarian pore-forming toxins and the signalling pathways that might be involved in these cellular responses. Since PFTs represent potential candidates for targeted toxin therapy for the treatment of numerous cancers, we also address the challenge to overcome the immunogenicity of these toxins when used as therapeutics in the host.