Next Article in Journal
Thiazoles and Thiazolidinones as COX/LOX Inhibitors
Next Article in Special Issue
ω-Methylsulfanylalkyl Glucosinolates: A General Synthetic Pathway
Previous Article in Journal
Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray
Previous Article in Special Issue
Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(3), 684; https://doi.org/10.3390/molecules23030684

A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles

1
Institute of Organic and Analytical Chemistry (ICOA), University of Orleans, UMR-CNRS 7311, BP 6759 F-45067 Orleans CEDEX 2, France
2
Institute of Molecular Chemistry and Materials of Orsay, UMR CNRS 8182, University of Paris-Sud, Building 420, 91400 Orsay, France
*
Author to whom correspondence should be addressed.
Academic Editor: Thierry Besson
Received: 27 February 2018 / Revised: 12 March 2018 / Accepted: 16 March 2018 / Published: 18 March 2018
(This article belongs to the Special Issue Focusing on Sulfur in Medicinal Chemistry)
Full-Text   |   PDF [5163 KB, uploaded 3 May 2018]   |  

Abstract

A simple and efficient methodology for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biological activities has been developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, leading to the expected compounds in excellent yields in only five minutes. View Full-Text
Keywords: PEG-400; nucleophilic aromatic substitution; nitrogen fused heterocycles PEG-400; nucleophilic aromatic substitution; nitrogen fused heterocycles
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Campos, J.F.; Loubidi, M.; Scherrmann, M.-C.; Berteina-Raboin, S. A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles. Molecules 2018, 23, 684.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top