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24 Results Found

  • Feature Paper
  • Review
  • Open Access
74 Citations
13,575 Views
31 Pages

Non–IgE- or Mixed IgE/Non–IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis

  • Mauro Calvani,
  • Caterina Anania,
  • Barbara Cuomo,
  • Enza D’Auria,
  • Fabio Decimo,
  • Giovanni Cosimo Indirli,
  • Gianluigi Marseglia,
  • Violetta Mastrorilli,
  • Marco Ugo Andrea Sartorio and
  • Elisabetta Veronelli
  • + 1 author

14 January 2021

non-IgE and mixed gastrointestinal food allergies present various specific, well-characterized clinical pictures such as food protein-induced allergic proctocolitis, food protein-induced enterocolitis and food protein-induced enteropathy syndrome as...

  • Review
  • Open Access
136 Citations
23,793 Views
29 Pages

Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update

  • Roxane Labrosse,
  • François Graham and
  • Jean-Christoph Caubet

14 July 2020

Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which...

  • Review
  • Open Access
21 Citations
7,685 Views
17 Pages

Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches

  • Elisa Zubeldia-Varela,
  • Tomás Clive Barker-Tejeda,
  • Frank Blanco-Pérez,
  • Sonsoles Infante,
  • José M. Zubeldia and
  • Marina Pérez-Gordo

2 November 2021

Non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) is the name given to a series of pathologies whose main entities are food protein-induced allergic proctocolitis (FPIAP), food protein-induced enteropathy (FPE), and food protein-induced...

  • Article
  • Open Access
9 Citations
2,561 Views
9 Pages

Assessing Feeding Difficulties in Children Presenting with Non-IgE-Mediated Gastrointestinal Food Allergies—A Commonly Reported Problem

  • Adriana Chebar-Lozinsky,
  • Claire De Koker,
  • Robert Dziubak,
  • Daniel Lorber Rolnik,
  • Heather Godwin,
  • Gloria Dominguez-Ortega,
  • Ana-Kristina Skrapac,
  • Yara Gholmie,
  • Kate Reeve and
  • Rosan Meyer
  • + 1 author

22 May 2024

Many guidelines have been published to help diagnose food allergies, which have included feeding difficulties as a presenting symptom (particularly for non-IgE-mediated gastrointestinal allergies). This study aimed to investigate the prevalence of fe...

  • Article
  • Open Access
1 Citations
1,883 Views
13 Pages

The Impact of Dietary Counseling on the Nutritional Status of Pediatric Patients with Non-IgE-Mediated Gastrointestinal Food Allergies: A Non-Randomized, Prospective Intervention Study

  • Serena Coppola,
  • Laura Carucci,
  • Alessandra Agizza,
  • Rita Nocerino,
  • Rosilenia Carandente,
  • Maria Francesca Catalano and
  • Roberto Berni Canani

19 March 2025

Background/Objectives: Pediatric patients with non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFAs) may experience alterations of nutritional status. This non-randomized, prospective intervention study investigated the impact of dietary c...

  • Article
  • Open Access
6 Citations
2,616 Views
9 Pages

Analysis of Serum Th2 Cytokines in Infants with Non-IgE Mediated Food Allergy Compared to Healthy Infants

  • Francesco Savino,
  • Francesca Giuliani,
  • Stefano Giraudi,
  • Ilaria Galliano,
  • Paola Montanari,
  • Valentina Daprà and
  • Massimiliano Bergallo

9 April 2022

Background: The aim of this study is to assess the serum values of IL-4, IL-5, IL-10, and IL-13 in a group of infants with non-IgE mediated food allergies treated with a hydrolyzed formula and compare them with a group of healthy peers. Methods: A to...

  • Article
  • Open Access
8 Citations
4,126 Views
9 Pages

Food Protein-Induced Enterocolitis Syndrome in Children with Down Syndrome: A Pilot Case-Control Study

  • Fumiko Okazaki,
  • Hiroyuki Wakiguchi,
  • Yuno Korenaga,
  • Kazumasa Takahashi,
  • Hiroki Yasudo,
  • Ken Fukuda,
  • Mototsugu Shimokawa and
  • Shunji Hasegawa

17 January 2022

Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobin E-mediated food hypersensitivity disorder. However, little is known about the clinical features of FPIES in patients with Down syndrome (DS). Medical records of children with D...

  • Review
  • Open Access
7 Citations
8,385 Views
23 Pages

Nutritional Aspects of Pediatric Gastrointestinal Diseases

  • Teresa Di Chio,
  • Christiane Sokollik,
  • Diego G. Peroni,
  • Lara Hart,
  • Giacomo Simonetti,
  • Franziska Righini-Grunder and
  • Osvaldo Borrelli

19 June 2021

In the last decade, the role of nutritional management in pediatric gastrointestinal diseases has gained increasing popularity. Disease-specific diets have been introduced as conventional treatments by international guidelines. Patients tend to more...

  • Review
  • Open Access
58 Citations
11,352 Views
15 Pages

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

  • Licia Pensabene,
  • Silvia Salvatore,
  • Enza D'Auria,
  • Francesca Parisi,
  • Daniela Concolino,
  • Osvaldo Borrelli,
  • Nikhil Thapar,
  • Annamaria Staiano,
  • Yvan Vandenplas and
  • Miguel Saps

9 November 2018

The role and prevalence of cow’s milk protein allergy (CMA) in functional gastrointestinal disorders remains unclear. The aim of this review is to update knowledge on the relationship between CMA and functional abdominal pain disorders (FAPDs)...

  • Article
  • Open Access
20 Citations
3,724 Views
10 Pages

29 September 2020

Diagnosis of non-IgE mediated food allergy presents a special challenge due to lack of a single, non-invasive diagnostic method. We selected three fecal biomarkers of allergic inflammation of gastrointestinal origin in order to improve the diagnostic...

  • Review
  • Open Access
3,156 Views
10 Pages

Food Allergy-Associated Cutaneous Manifestations in Children: A Narrative Review

  • Annabel Hou,
  • Joyce J. Zhu,
  • Pratiksha Patra and
  • Sharon Albers

The rising prevalence of pediatric food allergies represents a growing public health concern, with hospitalizations for food-induced anaphylaxis on the rise. Early cutaneous manifestations, particularly in the setting of atopic dermatitis (AD), may i...

  • Review
  • Open Access
44 Citations
17,976 Views
17 Pages

Cow’s Milk Allergy or Gastroesophageal Reflux Disease—Can We Solve the Dilemma in Infants?

  • Silvia Salvatore,
  • Massimo Agosti,
  • Maria Elisabetta Baldassarre,
  • Enza D’Auria,
  • Licia Pensabene,
  • Luana Nosetti and
  • Yvan Vandenplas

21 January 2021

Cow’s milk allergy (CMA) and gastro-esophageal reflux disease (GERD) may manifest with similar symptoms in infants making the diagnosis challenging. While immediate reaction to cow’s milk protein indicate CMA, regurgitation, vomiting, cry...

  • Article
  • Open Access
12 Citations
3,409 Views
13 Pages

19 October 2022

Background: Food allergy (FA) has a broad range of symptoms, and clinical manifestations may concern several reactions from one system or organ. Aim: The aim of the study was to assess intestinal permeability (IP) based on the analysis of serum zonul...

  • Review
  • Open Access
23 Citations
8,508 Views
20 Pages

Tomatoes are one of the most broadly produced and consumed crop plants. They are the source of health-promoting nutrients such as antioxidants, including ascorbic acid, polyphenols, or carotenoids. Despite the beneficial role of tomatoes in the daily...

  • Review
  • Open Access
4 Citations
5,225 Views
17 Pages

Management of Adult Patients with Gastrointestinal Symptoms from Food Hypersensitivity—Narrative Review

  • Alina Kanikowska,
  • Susanne Janisz,
  • Dorota Mańkowska-Wierzbicka,
  • Marcin Gabryel,
  • Agnieszka Dobrowolska and
  • Piotr Eder

9 December 2022

The incidence of food hypersensitivity has increased dramatically over the years not only among children but also in adults. Adult patients are usually less suspected of food hypersensitivity symptoms since food allergies are more typical for small c...

  • Review
  • Open Access
8 Citations
7,334 Views
27 Pages

Food Hypersensitivity: Distinguishing Allergy from Intolerance, Main Characteristics, and Symptoms—A Narrative Review

  • Gregory Hage,
  • Yonna Sacre,
  • Joanne Haddad,
  • Marcel Hajj,
  • Lea Nicole Sayegh and
  • Nicole Fakhoury-Sayegh

16 April 2025

Background/Objectives: Food hypersensitivity remains an understudied and overlooked subject globally. It is characterized by adverse reactions to dietary substances, potentially triggered by various mechanisms. Food allergy, a subset of food hypersen...

  • Brief Report
  • Open Access
6 Citations
2,417 Views
6 Pages

Down Syndrome in FPIES: An Overwhelming and Unexpected Prevalence

  • Valentina Pecora,
  • Maurizio Mennini,
  • Rocco Valluzzi,
  • Vincenzo Fierro,
  • Alberto Villani,
  • Diletta Valentini and
  • Alessandro Fiocchi

13 July 2022

Down syndrome (DS) is one of the most common chromosomal anomalies. Gastrointestinal disorders in DS are predominantly related to anatomical anomalies and celiac disease. In 2015, the first two cases of non-IgE-mediated food allergy in patients with...

  • Article
  • Open Access
916 Views
13 Pages

Prevalence Clinical Syndromes and Outcomes of Cow’s Milk Allergy in Children: A Four-Year Follow-Up

  • Ioannis Xinias,
  • Charalampos Agakidis,
  • Theodora Delaporta,
  • Stilianos Xinias,
  • Ioannis Roilidis,
  • Georgios Xinias and
  • Antigoni Mavroudi

21 November 2025

Background/Objectives: Cow’s milk allergy (CMA) manifests with various clinical syndromes and has a wide range of symptoms in infants. This study aims to investigate the prevalence, clinical presentation, and outcome of clinical types and subty...

  • Case Report
  • Open Access
3 Citations
5,008 Views
10 Pages

Follow-Up of a Rare Case of Eosinophilic Gastroenteritis Associated with Persistent Blood Eosinophilia and Multiple Food Allergies

  • Polliana Mihaela Leru,
  • Vlad Florin Anton,
  • Ioana Adriana Muntean,
  • Carmen Daniela Neagoe and
  • Dumitru Matei

Eosinophilic gastroenteritis (EGE) is a subgroup of the eosinophilic gastro-intestinal disorders (EGIDs), characterized by eosinophilic infiltration and chronic inflammation of the gastrointestinal tract. These are rare diseases with still incomplete...

  • Article
  • Open Access
3,623 Views
13 Pages

Fecal Calprotectin Determination in a Cohort of Children with Cow’s Milk Allergy

  • Caterina Anania,
  • Filippo Mondì,
  • Giulia Brindisi,
  • Alessandra Spagnoli,
  • Daniela De Canditiis,
  • Arianna Gesmini,
  • Lavinia Marchetti,
  • Alessia Fichera,
  • Maria Grazia Piccioni and
  • Francesca Olivero
  • + 1 author

6 January 2025

Cow’s milk allergy (CMA) is the most common food allergy among children. An oral food challenge (OFC) remains a mainstay of the diagnosis of CMA, especially for the non-IgE-mediated type; however, this test can be risky and time-consuming. Henc...

  • Case Report
  • Open Access
2 Citations
3,451 Views
11 Pages

Pollen Sensitization Can Increase the Allergic Reaction to Non-Cross-Reactive Allergens in a Soy-Allergic Patient

  • Daniela Briceno Noriega,
  • Huub F. J. Savelkoul,
  • Ad Jansen,
  • Malgorzata Teodorowicz and
  • Janneke Ruinemans-Koerts

During and after the pollen season, an increase in food-triggered allergic symptoms has been observed in pollen-food syndrome patients, possibly due to seasonal boosting of pollen-IgE levels. It has been suggested that consumption of birch-pollen-rel...

  • Article
  • Open Access
419 Views
17 Pages

Identifying Predictors for the Acquisition of Tolerance to Cow’s Milk Protein in Infants with Food Protein-Induced Allergic Proctocolitis (FPIAP): Multifactorial Analysis of Two Italian Cohorts

  • Andrea Scavella,
  • Cristina Ferrigno,
  • Mario Baù,
  • Alessandra Colombo,
  • Claudia Ivonne Tavernelli,
  • Marianna Zobele,
  • Roberta Borgetto,
  • Alessandra Maggi,
  • Alice Baronti and
  • Silvia Salvatore
  • + 4 authors

27 December 2025

Background/Objectives: Food protein-induced allergic proctocolitis (FPIAP) is a non-IgE-mediated gastrointestinal food allergy. Although tolerance to the culprit food is usually achieved within the first year of life, late acquisition occurs and rema...

  • Article
  • Open Access
1,109 Views
13 Pages

Background: Cow-milk-induced allergic proctocolitis (CMIAP) is a non-IgE-mediated food hypersensitivity that often resolves spontaneously but may predispose infants to IgE-mediated allergies and eosinophilic gastrointestinal disorders. Understanding...