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43 Results Found

  • Feature Paper
  • Article
  • Open Access
12 Citations
3,494 Views
8 Pages

Efficacy of Reciprocating Instruments in the Removal of Bioceramic and Epoxy Resin-Based Sealers: Micro-CT Analysis

  • Marko Rajda,
  • Ivana Miletić,
  • Gorana Baršić,
  • Silvana Jukić Krmek,
  • Damir Šnjarić and
  • Anja Baraba

5 November 2021

The objective of this study was to evaluate the efficacy of reciprocating instruments in the removal of bioceramic and epoxy resin-based sealers using micro-CT analysis. Root canals of 40 extracted human teeth were instrumented with a size R25 Recipr...

  • Article
  • Open Access
52 Citations
4,308 Views
14 Pages

Comparison of Biocompatibility of Calcium Silicate-Based Sealers and Epoxy Resin-Based Sealer on Human Periodontal Ligament Stem Cells

  • Hanseul Oh,
  • Egan Kim,
  • Sukjoon Lee,
  • Soyeon Park,
  • Dongzi Chen,
  • Su-Jung Shin,
  • Euiseong Kim and
  • Sunil Kim

20 November 2020

The aim of this study was to evaluate the biocompatibility of calcium silicate-based sealers (CeraSeal and EndoSeal TCS) and epoxy resin-based sealer (AH-Plus) in terms of cell viability, inflammatory response, expression of mesenchymal phenotype, os...

  • Article
  • Open Access
12 Citations
3,321 Views
15 Pages

22 April 2024

Introduction: We compared the effects of heat on the physicochemical properties of recently developed calcium silicate-based sealers (CSBSs), including BioRoot Flow, BioRoot RCS, and AH Plus Bioceramic sealer, with those of the epoxy-resin-based seal...

  • Article
  • Open Access
12 Citations
3,429 Views
10 Pages

Cytotoxicity and Genotoxicity of Epoxy Resin-Based Root Canal Sealers before and after Setting Procedures

  • Mijoo Kim,
  • Marc Hayashi,
  • Bo Yu,
  • Thomas K. Lee,
  • Reuben H. Kim and
  • Deuk-won Jo

7 June 2022

Epoxy resin-based sealers are commonly used for successful endodontic treatment. This study aimed to evaluate the cytotoxicity and genotoxicity of epoxy resin-based sealers under unset and set conditions. Three epoxy resin-based sealers were used: Ad...

  • Feature Paper
  • Review
  • Open Access
24 Citations
8,131 Views
27 Pages

Antibacterial Additives in Epoxy Resin-Based Root Canal Sealers: A Focused Review

  • Alexander Brezhnev,
  • Prasanna Neelakantan,
  • Ray Tanaka,
  • Sergey Brezhnev,
  • George Fokas and
  • Jukka P. Matinlinna

1 July 2019

Dental materials used in root canal treatment have undergone substantial improvements over the past decade. However, one area that still remains to be addressed is the ability of root canal fillings to effectively entomb, kill bacteria, and prevent t...

  • Review
  • Open Access
3 Citations
6,986 Views
12 Pages

Epoxy vs. Calcium Silicate-Based Root Canal Sealers for Different Clinical Scenarios: A Narrative Review

  • Hadas Azizi,
  • Avi Hadad,
  • Dan Henry Levy,
  • Joe Ben Itzhak,
  • Hyeon-Cheol Kim and
  • Michael Solomonov

25 March 2024

This study aimed to review the considerations for choosing a suitable sealer according to various endodontic scenarios. An electronic search of PubMed, Scopus, and the Web of Science was undertaken for the keywords of ‘sealer choosing’, &...

  • Article
  • Open Access
23 Citations
4,361 Views
9 Pages

25 July 2022

The purpose of this randomized controlled clinical trial was to assess the short-term clinical effectiveness of sealer-based root canal obturation using calcium-silicate-based sealer (CSBS) and epoxy-resin-based sealer (ERBS). A total of eighty patie...

  • Article
  • Open Access
3 Citations
2,587 Views
12 Pages

Medium- and Long-Term Re-Treatment of Root Canals Filled with a Calcium Silicate-Based Sealer: An Experimental Ex Vivo Study

  • Giulia Bardini,
  • Elisabetta Cotti,
  • Terenzio Congiu,
  • Claudia Caria,
  • Davide Aru and
  • Montse Mercadè

13 May 2022

This study investigated the possibility of re-treating a calcium silicate-based sealer (CSBS), compared to an epoxy-resin sealer (RBS), using rotary instrumentation at different times from obturation (1 month/1 year). Thirty-six human mandibular prem...

  • Article
  • Open Access
16 Citations
3,971 Views
11 Pages

Impact of Immersion Media on Physical Properties and Bioactivity of Epoxy Resin-Based and Bioceramic Endodontic Sealers

  • Thais Gomes de Moraes,
  • Alan Silva de Menezes,
  • Renata Grazziotin-Soares,
  • Rafael Ubaldo Moreira e Moraes,
  • Paulo Vitor Campos Ferreira,
  • Ceci Nunes Carvalho,
  • Jose Bauer and
  • Edilausson Moreno Carvalho

14 February 2022

This study assessed the effects of immersion media [distilled water (dw), phosphate buffered saline (pbs) and simulated body fluid (sbf)] in the physical properties [fluid uptake/sorption/solubility and alkalinization activity (pH)] and bioactivity o...

  • Article
  • Open Access
10 Citations
3,197 Views
10 Pages

Efficacy and Cytotoxicity of Binary Mixtures as Root Canal Filling Solvents

  • Inês Ferreira,
  • Liliana Grenho,
  • Pedro Gomes,
  • Ana Cristina Braga,
  • Maria Helena Fernandes,
  • Maria Ascensão Lopes and
  • Irene Pina-Vaz

21 July 2020

Objectives: This study reports the efficacy of two solvent mixtures on the dissolution of gutta-percha and AH Plus sealer, together with the cytotoxicity. Methods: Methyl ethyl ketone (MEK), orange oil, tetrachloroethylene, MEK/tetrachloroethylene (1...

  • Article
  • Open Access
429 Views
14 Pages

26 November 2025

This study aims to compare the osteogenic potential of premixed hydraulic calcium silicate-based sealers (HCSSs) with an epoxy resin-based sealer in human bone marrow-derived stem cells (hBMSCs). Three HCSSs (White Endoseal MTA, One-Fil, EndoSequence...

  • Article
  • Open Access
41 Citations
5,462 Views
12 Pages

In Vitro Comparison of Biocompatibility of Calcium Silicate-Based Root Canal Sealers

  • Ju Kyung Lee,
  • Sunil Kim,
  • Sukjoon Lee,
  • Hyeon-Cheol Kim and
  • Euiseong Kim

29 July 2019

The aim of this study was to assess the effect of three calcium silicate-based sealers (EndoSeal MTA, Nano-ceramic Sealer, and Wellroot ST) and two epoxy resin-based sealers (AH-Plus, AD Seal) on various aspects, such as cell viability, inflammatory...

  • Article
  • Open Access
2 Citations
4,810 Views
10 Pages

Antibiofilm Efficacy of Calcium Silicate-Based Endodontic Sealers

  • Matilde Ruiz-Linares,
  • Vsevolod Fedoseev,
  • Carmen Solana,
  • Cecilia Muñoz-Sandoval and
  • Carmen María Ferrer-Luque

8 August 2024

Background: Using endodontic sealers with long-term antimicrobial properties can increase the success of endodontic treatment. This study aimed to assess the antimicrobial activity over time of two calcium silicate (CS)-based sealers, AH Plus Biocera...

  • Article
  • Open Access
5 Citations
3,961 Views
13 Pages

The Short-Term Antibacterial Activity of Three Selected Endodontic Sealers against Enterococcus faecalis Bacterial Culture

  • Matej Rosa,
  • Yuliya Morozova,
  • Roman Moštěk,
  • Pavel Holík,
  • Lucia Somolová,
  • Barbora Novotná,
  • Soňa Zábojníková,
  • Kateřina Bogdanová,
  • Kateřina Langová and
  • Josef Paul Kovařík
  • + 2 authors

21 January 2022

(1) Background: Microorganisms originating from the microflora of the oral cavity are the main cause of the inflammatory diseases of the dental pulp and periapical periodontium, as well as the failure of endodontic treatment. The subsequent root cana...

  • Article
  • Open Access
75 Citations
7,250 Views
12 Pages

Comparative Cytocompatibility and Mineralization Potential of Bio-C Sealer and TotalFill BC Sealer

  • Sergio López-García,
  • Miguel R. Pecci-Lloret,
  • Julia Guerrero-Gironés,
  • María P. Pecci-Lloret,
  • Adrián Lozano,
  • Carmen Llena,
  • Francisco Javier Rodríguez-Lozano and
  • Leopoldo Forner

22 September 2019

The aim of this study was to investigate the cytocompatibility and mineralization potential of two premixed hydraulic endodontic sealers compared with an epoxy resin-based root canal sealer. The cellular responses and mineralization capacity were stu...

  • Article
  • Open Access
18 Citations
3,308 Views
11 Pages

Dentinal Tubule Penetrability and Bond Strength of Two Novel Calcium Silicate-Based Root Canal Sealers

  • Karissa Shieh,
  • Jack Yang,
  • Elsa Heng Zhu,
  • Ove Andreas Peters and
  • Sepanta Hosseinpour

23 April 2023

Background: Once the chemo-mechanical preparation of root canals is finished, achieving a complete seal of the root canal system becomes crucial in determining the long-term success of endodontic treatment. The important goals of root canal obturatio...

  • Article
  • Open Access
8 Citations
5,921 Views
10 Pages

21 November 2017

This laboratory study assessed removability of endodontic alkaline cements and resin sealers using coronal cross-sectional slices of roots with single canals. Materials were labelled with 0.1% (w/w) sodium fluorescein prior to mixing so that confocal...

  • Article
  • Open Access
18 Citations
5,068 Views
9 Pages

25 July 2018

Root canal sealers should have good wetting and adhesion with intraradicular dentin. This study evaluated the wetting and adhesion properties of three bioceramic root canal sealers on dentin using contact angle (CA) measurements and calculations base...

  • Article
  • Open Access
2 Citations
1,759 Views
13 Pages

In Vitro Microscopical and Microbiological Assessment of the Sealing Ability of Calcium Silicate-Based Root Canal Sealers

  • Karin Christine Huth,
  • Sabina Noreen Wuersching,
  • Leander Benz,
  • Stefan Kist and
  • Maximilian Kollmuss

12 November 2024

This in vitro study evaluated the sealing ability and microleakage of calcium silicate-based sealers compared to an epoxy resin-based sealer. One hundred twenty-five roots from anterior teeth were chemo-mechanically prepared and divided into four gro...

  • Review
  • Open Access
88 Citations
10,109 Views
21 Pages

Calcium Silicate-Based Root Canal Sealers: A Narrative Review and Clinical Perspectives

  • Germain Sfeir,
  • Carla Zogheib,
  • Shanon Patel,
  • Thomas Giraud,
  • Venkateshbabu Nagendrababu and
  • Frédéric Bukiet

15 July 2021

Over the last two decades, calcium silicate-based materials have grown in popularity. As root canal sealers, these formulations have been extensively investigated and compared with conventional sealers, such as zinc oxide–eugenol and epoxy resin-base...

  • Article
  • Open Access
6 Citations
6,218 Views
11 Pages

Assessment of Bacterial Sealing Ability of Two Different Bio-Ceramic Sealers in Single-Rooted Teeth Using Single Cone Obturation Technique: An In Vitro Study

  • Doaa M. AlEraky,
  • Ahmed M. Rahoma,
  • Hatem M. Abuohashish,
  • Abdullh AlQasser,
  • Abbas AlHamali,
  • Hussain M. AlHussain,
  • Hussain M. AlShoalah,
  • Zakrya AlSaghah,
  • Abdulrahman Khattar and
  • Shimaa Rifaat

24 February 2023

The long-term success of root canal treatment requires the prevention of bacterial leakage between canal walls and root canal obturation. In this study, we compared the leakage of Enterococcus faecalis in thirty single-rooted mandibular premolars div...

  • Systematic Review
  • Open Access
30 Citations
4,448 Views
18 Pages

29 December 2021

Introduction: The aim of this systematic review is to analyse the effect of physico-chemical properties of calcium silicate-based sealers in comparison to epoxy resin sealers in permanent teeth using a single-cone obturation technique. Methods: The s...

  • Article
  • Open Access
7 Citations
3,030 Views
13 Pages

Comparative Assessment of Push-Out Bond Strength and Dentinal Tubule Penetration of Different Calcium-Silicate-Based Endodontic Sealers

  • Mihai Merfea,
  • Sanda Ileana Cimpean,
  • Radu Stefan Chiorean,
  • Aurora Antoniac,
  • Ada Gabriela Delean,
  • Iulia Clara Badea and
  • Mindra Eugenia Badea

6 December 2024

Background: Adhesion within endodontic obturation material and root canal walls improves the efficacy of the endodontic treatment by establishing a barrier that inhibits reinfection and entombs residual bacteria. This study evaluates the push-out bon...

  • Article
  • Open Access
1 Citations
1,148 Views
19 Pages

Bond Strength of an Epoxy Resin Root Canal Sealer Prototype

  • Matthias J. Roggendorf,
  • Hubert C. Roggendorf,
  • Markus Müller-Krott,
  • Franz-Josef Faber and
  • Roland Frankenberger

9 September 2025

Background/Objectives: We aimed to assess the bond strength of AH Plus Jet (AH) and an epoxy resin-based root canal sealer prototype (K-0189) adhered to three different obturation points. Methods: A total of 120 single-rooted teeth were selected afte...

  • Article
  • Open Access
12 Citations
3,782 Views
10 Pages

Impact of Final Irrigation Protocol on the Push-Out Bond Strength of Two Types of Endodontic Sealers

  • Germain Sfeir,
  • Frédéric Bukiet,
  • Wajih Hage,
  • Roula El Hachem and
  • Carla Zogheib

21 February 2023

Aim: The aim of this study was to assess the impact of the final irrigation protocol on the push-out bond strength of calcium silicate-based sealers when compared to an epoxy resin-based sealer. Materials and Methods: Eighty-four single-rooted mandib...

  • Article
  • Open Access
1 Citations
3,916 Views
18 Pages

An Evaluation of the Biocompatibility and Chemical Properties of Two Bioceramic Root Canal Sealers in a Sealer Extrusion Model of Rat Molars

  • Shintaro Takahara,
  • Naoki Edanami,
  • Razi Saifullah Ibn Belal,
  • Kunihiko Yoshiba,
  • Shoji Takenaka,
  • Naoto Ohkura,
  • Nagako Yoshiba,
  • Susan Gomez-Kasimoto and
  • Yuichiro Noiri

This study assessed the biocompatibility and chemical properties of two bioceramic root canal sealers, EndoSequence BC Sealer (EBC) and Nishika Canal Sealer BG (NBG), using a sealer extrusion model. Eight-week-old male Wistar rats were used. The mesi...

  • Article
  • Open Access
19 Citations
6,163 Views
10 Pages

Evaluation of the Sealing Ability and Bond Strength of Two Endodontic Root Canal Sealers: An In Vitro Study

  • Manuel Marques Ferreira,
  • José Pedro Martinho,
  • Inês Duarte,
  • Diogo Mendonça,
  • Ana Catarina Craveiro,
  • Maria Filomena Botelho,
  • Eunice Carrilho,
  • Carlos Miguel Marto,
  • Ana Coelho and
  • Ana Margarida Abrantes
  • + 3 authors

26 October 2022

Background: Obturation represents a critical step in endodontic treatment, which relies on a core material and a sealer. This study aims to evaluate the sealing ability and bond strength to the root canal walls of an epoxy resin-based sealer (AH-Plus...

  • Article
  • Open Access
2,080 Views
13 Pages

Push-Out Bond Strength of Three Bioceramic Sealers to Root Canal Dentin After Different Irrigation Protocols

  • Zoran Urošević,
  • Violeta Petrović,
  • Ivana Milanović,
  • Vojislav Komlenić,
  • Tatjana Savić-Stanković and
  • Jugoslav Ilić

26 August 2025

The adhesion of endodontic sealers to dentin may be influenced both by the chemical composition of the sealer and the final irrigation protocol. The aim of this study was to examine the push-out bond strength of three differently formulated biocerami...

  • Article
  • Open Access
1 Citations
1,017 Views
10 Pages

21 November 2025

Background/Objectives: The clinical outcome of root canal treatments using calcium silicate-based sealer (CSBS) remains unclear. This study aimed to evaluate the 1-year effect of CSBS in combination with a single-cone obturation technique on periapic...

  • Article
  • Open Access
2 Citations
4,181 Views
14 Pages

Assessing the Sealing Performance and Clinical Outcomes of Endodontic Treatment in Patients with Chronic Apical Periodontitis Using Epoxy Resin and Calcium Salicylate Seals

  • Razvan Mihai Horhat,
  • Bogdan Andrei Bumbu,
  • Laura Orel,
  • Oana Velea-Barta,
  • Laura Cirligeriu,
  • Gratiana Nicoleta Chicin,
  • Marius Pricop,
  • Mircea Rivis,
  • Stefania Dinu and
  • Luminita Maria Nica
  • + 4 authors

13 June 2023

Background and Objectives: Recognizing the significance of a hermetic apical seal for successful root canal treatment, the present investigation aimed to evaluate two sealing materials through an in vitro analysis, as well as to ascertain the clinica...

  • Article
  • Open Access
1,684 Views
11 Pages

7 September 2023

Introduction: The effect of high temperatures on the properties of endodontic sealers during warm compaction of gutta-percha may be a matter of concern. This study aimed to evaluate the effect of heat on the biocompatibility and bioactivity of EndoSe...

  • Article
  • Open Access
88 Citations
10,058 Views
21 Pages

Chemical-Physical Properties and Bioactivity of New Premixed Calcium Silicate-Bioceramic Root Canal Sealers

  • Fausto Zamparini,
  • Carlo Prati,
  • Paola Taddei,
  • Andrea Spinelli,
  • Michele Di Foggia and
  • Maria Giovanna Gandolfi

11 November 2022

The aim of the study was to analyze the chemical–physical properties and bioactivity (apatite-forming ability) of three recently introduced premixed bioceramic root canal sealers containing varied amounts of different calcium silicates (CaSi):...

  • Review
  • Open Access
5 Citations
6,976 Views
15 Pages

Contemporary Concepts of Adhesive Cementation of Glass-Fiber Posts: A Narrative Review

  • Panayiotis Tsolomitis,
  • Sofia Diamantopoulou and
  • Efstratios Papazoglou

14 June 2024

(1) Background: Cementation of glass fiber posts to root canals has been associated with various failures, especially debonding. This narrative review aims to present the contemporary concepts concerning the adhesive cementation of glass fiber post a...

  • Article
  • Open Access
8 Citations
2,452 Views
9 Pages

21 April 2023

This study sought to evaluate the efficacy of SWEEPS in the removal of epoxy-resin-based and calcium-silicate-containing endodontic sealer combined with single-cone and carrier-based obturation techniques through a micro-CT analysis. Seventy-six sing...

  • Article
  • Open Access
29 Citations
4,512 Views
16 Pages

The Use of Premixed Calcium Silicate Bioceramic Sealer with Warm Carrier-Based Technique: A 2-Year Study for Patients Treated in a Master Program

  • Fausto Zamparini,
  • Andrea Spinelli,
  • Filippo Cardinali,
  • Pietro Ausiello,
  • Maria Giovanna Gandolfi and
  • Carlo Prati

Background: Recently several calcium silicate flowable sealers have been introduced as endodontic materials for the root canal. This clinical study tested the use of a new premixed calcium silicate bioceramic sealer in association with the Thermafil...

  • Feature Paper
  • Article
  • Open Access
32 Citations
4,275 Views
10 Pages

Debunking the Concept of Dentinal Tubule Penetration of Endodontic Sealers: Sealer Staining with Rhodamine B Fluorescent Dye Is an Inadequate Method

  • David Donnermeyer,
  • Sina Schmidt,
  • Arno Rohrbach,
  • Johannes Berlandi,
  • Sebastian Bürklein and
  • Edgar Schäfer

10 June 2021

The aim of this study was to investigate the suitability of rhodamine B dye staining of an epoxy resin sealer (AH Plus) and calcium-silicate-based sealers (Total Fill BC Sealer, BioRoot RCS) to represent the penetration depth of the sealers into dent...

  • Article
  • Open Access
2 Citations
1,771 Views
11 Pages

12 April 2023

Rotary instrumentation has been proposed in undergraduate teaching. The aim of this study was to evaluate student’s performance, through the obturation quality and treatment time, in a sequential range of L-simulated root canals. A senior under...

  • Article
  • Open Access
9 Citations
4,019 Views
13 Pages

Dentin Sealing of Calcium Silicate-Based Sealers in Root Canal Retreatment: A Confocal Laser Microscopy Study

  • Blanca Ortiz-Blanco,
  • José Luis Sanz,
  • Carmen Llena,
  • Adrián Lozano and
  • Leopoldo Forner

The aim of the present in vitro study was to evaluate the intratubular penetration of three bioceramic sealers in root canal retreatment. Here, 30 single-rooted human teeth were instrumented with the Protaper Universal system and filled with gutta-pe...

  • Article
  • Open Access
14 Citations
5,228 Views
10 Pages

5 September 2018

The aim of this study was to evaluate the influence of calcium-silicate-based sealer (Endosequence-BC-Sealer) in roots, filled with thermo-plasticized injectable technique aided by Calamus-Flow-Delivery-System, on bond strength to radicular dentin, i...

  • Article
  • Open Access
12 Citations
4,078 Views
10 Pages

Minimal Dentinal Tubule Penetration of Endodontic Sealers in Warm Vertical Compaction by Direct Detection via SEM Analysis

  • Sina Schmidt,
  • Edgar Schäfer,
  • Sebastian Bürklein,
  • Arno Rohrbach and
  • David Donnermeyer

27 September 2021

Sealer staining using rhodamine B dye to investigate the penetration depth of endodontic sealers was proven unsuitable for this purpose. This study aimed to investigate the sealer penetration depth into dentinal tubules by scanning electron microscop...

  • Article
  • Open Access
10 Citations
3,474 Views
11 Pages

A Novel Bioactive Endodontic Sealer Containing Surface-Reaction-Type Prereacted Glass-Ionomer Filler Induces Osteoblast Differentiation

  • Nobuyuki Kawashima,
  • Kentaro Hashimoto,
  • Masashi Kuramoto,
  • Alamuddin Bakhit,
  • Yasumiko Wakabayashi and
  • Takashi Okiji

9 October 2020

Surface-reaction-type prereacted glass-ionomer (S-PRG) fillers exhibit bioactive properties by the release of multiple ions. This study examined whether a novel endodontic sealer containing S-PRG fillers (PRG+) has the capacity to induce osteoblast d...

  • Article
  • Open Access
3 Citations
3,558 Views
10 Pages

Interfacial Biomaterial–Dentin Bacterial Biofilm Proliferation and Viability Is Affected by the Material, Aging Media and Period

  • Muna Q. Marashdeh,
  • Celine Lévesque,
  • Shimon Friedman,
  • Cameron A. Stewart and
  • Yoav Finer

24 February 2022

Biomaterial–dentin interfaces undergo degradation over time, allowing salivary, tissue fluid, and bacterial movement between the root filling or restoration and dentin. This study aims to investigate the effect of aging in simulated human salivary/ba...

  • Article
  • Open Access
14 Citations
5,283 Views
12 Pages

The Efficacy of Rotary, Reciprocating, and Combined Non-Surgical Endodontic Retreatment Techniques in Removing a Carrier-Based Root Canal Filling Material from Straight Root Canal Systems: A Micro-Computed Tomography Analysis

  • Tarek-Fahed Alakabani,
  • Vicente Faus-Llácer,
  • Ignacio Faus-Matoses,
  • Celia Ruiz-Sánchez,
  • Álvaro Zubizarreta-Macho,
  • Salvatore Sauro and
  • Vicente Faus-Matoses

25 June 2020

The aim of this study is to analyze and compare the efficacy of three non-surgical endodontic retreatment techniques in removing a carrier-based root canal filling material from straight root canal systems. The study was performed on 99 single-rooted...