Changes in river plane shapes are called river planform changes (RPCs). Such changes can impact sustainable human development (e.g., human habitations, industrial and agricultural development, and national border security). RPCs can be identified thr...
Based on the flexible adjustment of the seven-wire, this study will assemble a new toughened seven-wire which is combined with a common single welding wire and the existing welding wire containing ductile alloy element (Ni element), and the microstru...
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) shows a promising therapeutic potential in cancer treatment as it exclusively causes apoptosis in a broad spectrum of cancer cells through triggering the extrinsic apoptosis pa...
Spinal cord injury (SCI) is an injurious process that begins with immediate physical damage to the spinal cord and associated tissues during an acute traumatic event. However, the tissue damage expands in both intensity and volume in the subsequent s...
What is the relationship between language and complex thought? In the context of deductive reasoning there are two main views. Under the first, which we label here the language-centric view, language is central to the syntax-like combinatorial operat...
2 December 2022
Renal fibrosis (RF) is a common reason for renal failure, and epithelial-mesenchymal transition (EMT) is a vital mechanism that promotes the development of RF. It is known that microRNA-10 (miR-10) plays an important role in cancer EMT; however, whet...
Multi-principal element alloys (MPEAs) are at the forefront of materials science due to their large variety of compositions, which can yield unexplored properties. Mapping the structure and properties of a compositional MPEA library in a reasonable t...
The introduction of v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors in melanoma patients with BRAF (V600E) mutations has demonstrated significant clinical benefits. However, rarely do tumours regress completely. Frequently, the reason...
The Max-cut problem is a well-known combinatorial optimization problem, which has many real-world applications. However, the problem has been proven to be non-deterministic polynomial-hard (NP-hard), which means that exact solution algorithms are not...
Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is interrupted, a rapid rebound of viremia is observed. The establis...
Conscious and unconscious brain mechanisms, including cognition, emotions and language are considered in this review. The fundamental mechanisms of cognition include interactions between bottom-up and top-down signals. The modeling of these interacti...
Dysregulation of the insulin-like growth factor (IGF) system determines the onset of various pathological conditions, including cancer. Accordingly, therapeutic strategies have been developed to block this system in tumor cells, but the results of cl...
Cost-effective therapy of neglected and tropical diseases such as malaria requires everlasting drug discovery efforts due to the rapidly emerging drug resistance of the plasmodium parasite. We have carried out computational design of new inhibitors o...
Immune checkpoint inhibitor (ICI) therapy has revolutionized the treatment of cancer, in particular lung cancer, while the introduction of predictive biomarkers from liquid biopsies has emerged as a promising tool to achieve an effective and personal...
As a classical combinatorial optimization problem, the traveling salesman problem (TSP) has been extensively investigated in the fields of Artificial Intelligence and Operations Research. Due to being NP-complete, it is still rather challenging to so...
Large Language Models (LLMs) have immensely advanced the field of Artificial Intelligence (AI), with recent models being able to perform chain-of-thought reasoning and solve complex mathematical problems, ranging from theorem proving to ones involvin...
In the process of tea plucking and leaf gathering, the structure optimization design of the leaf collecting mechanism is the key element responsible for collecting fresh leaves. The unreasonable design and manufacture of leaf collecting mechanisms wi...
Multiple myeloma (MM) remains an incurable disease and novel therapeutic agents/approaches are urgently needed. The PIM (Proviral insertion in murine malignancies) serine/threonine kinases have 3 isoforms: PIM1, PIM2, and PIM3. PIM kinases are engage...