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  • Article
  • Open Access
22 Citations
5,223 Views
10 Pages

Inhibition of Wnt3a/FOXM1/β-Catenin Axis and Activation of GSK3β and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers

  • Sung Min Hwang,
  • Hyo-Jung Lee,
  • Ji Hoon Jung,
  • Deok Yong Sim,
  • Jisung Hwang,
  • Ji Eon Park,
  • Bum Sang Shim and
  • Sung-Hoon Kim

10 September 2018

Although Moracin D derived from Morus alba was known to have anti-inflammatory and antioxidant activities, the underlying antitumor mechanism of Moracin D has not been unveiled thus far. Thus, in the recent study, the apoptotic mechanism of Moracin D...

(This article belongs to the Section Bioactives and Nutraceuticals)
  • Article
  • Open Access
1 Citations
1,624 Views
21 Pages

Moracin D Inhibits Gastric Cancer Progression Through B-Cell Lymphoma-2 (Bcl-2)-Mediated Cell Cycle Arrest and Apoptosis, Enhancing Chemotherapy Efficacy

  • Abdulkareem Qasem Moqbel,
  • He Yang,
  • Shunhui Liu,
  • Li Feng,
  • Muhammad Usman Ghani,
  • Xiaoxue Ke and
  • Hongjuan Cui

13 March 2026

Gastric cancer (GC) is a highly prevalent and rapidly progressing cancer with a poor prognosis, primarily due to chemoresistance and treatment-related toxicity. Moracin D (MD), a benzofuran extracted from Morus alba L., has shown potential antitumor...

(This article belongs to the Special Issue Novel Molecules for Cancer Treatment (3rd Edition))
  • Article
  • Open Access
44 Citations
8,177 Views
12 Pages

Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1

  • Ya-Nan Wang,
  • Mao-Feng Liu,
  • Wei-Zhen Hou,
  • Rui-Ming Xu,
  • Jie Gao,
  • An-Qi Lu,
  • Mei-Ping Xie,
  • Lan Li,
  • Jian-Jun Zhang and
  • Su-Juan Wang
  • + 4 authors

8 February 2017

Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis. The new compounds were identified as (9R)-moracin P 3...

(This article belongs to the Collection Bioactive Compounds)
  • Article
  • Open Access
102 Citations
13,286 Views
13 Pages

19 July 2011

A new arylbenzofuran, 3',5'-dihydroxy-6-methoxy-7-prenyl-2-arylbenzofuran (1), and 25 known compounds, including moracin R (2), moracin C (3), moracin O (4), moracin P (5), artoindonesianin O (6), moracin D (7), alabafuran A (8), mulberrofuran L (9),...

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
7 Citations
3,810 Views
17 Pages

Phenolic Compounds from Mori Cortex Ameliorate Sodium Oleate-Induced Epithelial–Mesenchymal Transition and Fibrosis in NRK-52e Cells through CD36

  • Yuan Ruan,
  • Pei-Pei Yuan,
  • Ya-Xin Wei,
  • Qi Zhang,
  • Li-Yuan Gao,
  • Pan-Ying Li,
  • Yi Chen,
  • Yang Fu,
  • Yan-Gang Cao and
  • Wei-Sheng Feng
  • + 1 author

11 October 2021

Lipid deposition in the kidney can cause serious damage to the kidney, and there is an obvious epithelial–mesenchymal transition (EMT) and fibrosis in the late stage. To investigate the interventional effects and mechanisms of phenolic compounds from...

  • Communication
  • Open Access
11 Citations
4,808 Views
10 Pages

Coumarin and Moracin Derivatives from Mulberry Leaves (Morus alba L.) with Soluble Epoxide Hydrolase Inhibitory Activity

  • Hong Xu Li,
  • Myungsook Heo,
  • Younghoon Go,
  • Young Soo Kim,
  • Young Ho Kim,
  • Seo Young Yang and
  • Wei Li

31 August 2020

This study identified three coumarins (1–3), and six moracin derivatives (4–9). The structures of these natural compounds were determined by the spectroscopic methods, including 1D and 2D NMR methods, and comparison with previous reported...

(This article belongs to the Special Issue Fragrant Molecules with Pharmacological Activities)
  • Article
  • Open Access
15 Citations
3,098 Views
12 Pages

Chemical Constituents from Ficus sagittifolia Stem Bark and Their Antimicrobial Activities

  • Olayombo M. Taiwo,
  • Olaoluwa O. Olaoluwa,
  • Olapeju O. Aiyelaagbe and
  • Thomas J. Schmidt

28 July 2023

The phytochemical investigation of the ethylacetate fraction of an ethanolic extract obtained from the stem bark of Ficus sagittifolia (Moraceae) led to the isolation of four flavonoids: (2R)-eriodictyol (1), 2′- hydroxygenistein (2), erycibeni...

(This article belongs to the Special Issue Natural Products and Phytotherapy: Advances in Phytochemistry and Pharmacology)
  • Article
  • Open Access
9 Citations
5,311 Views
10 Pages

Mulberroside F from In Vitro Culture of Mulberry and the Potential Use of the Root Extracts in Cosmeceutical Applications

  • Jiralapat Thamrongwatwongsa,
  • Nattaya Pattarapipatkul,
  • Titiradsadakorn Jaithon,
  • Ananya Jindaruk,
  • Atchara Paemanee,
  • Nattanan Panjaworayan T-Thienprasert and
  • Wannarat Pornsiriwong Phonphoem

28 December 2022

Mulberry (Morus spp.) is primarily used in sericulture, and its uses also extend to the food, pharmaceutical, and cosmetic industries. Mulberry extracts are rich in many bioactive compounds that exhibit a wide range of biological properties. Mulberro...

(This article belongs to the Special Issue New Insight into Research in In Vitro Plants Propagation)
  • Article
  • Open Access
8 Citations
4,624 Views
23 Pages

In Vitro Anti-Diabetic, Anti-Inflammatory, Antioxidant Activities and Toxicological Study of Optimized Psychotria malayana Jack Leaves Extract

  • Sharifah Nurul Akilah Syed Mohamad,
  • Alfi Khatib,
  • Siti Zaiton Mat So’ad,
  • Qamar Uddin Ahmed,
  • Zalikha Ibrahim,
  • Tanzina Sharmin Nipun,
  • Humaryanto Humaryanto,
  • Mohamed F. AlAjmi,
  • Shaden A. M. Khalifa and
  • Hesham R. El-Seedi

5 December 2023

Psychotria malayana Jack (Family: Rubiaceae, local name: Salung) is a traditional herb used to treat diabetes. A previous study by our research group demonstrated that P. malayana methanolic and water extract exhibits significant potential as an effe...

(This article belongs to the Special Issue Zebrafish as a Powerful Tool for Drug Discovery 2023)