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Open AccessArticle

Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1

1
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
2
GRU Cancer Center, Augusta University, Augusta, GA 30912, USA
3
Editorial Department, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Molecules 2017, 22(2), 236; https://doi.org/10.3390/molecules22020236
Received: 30 December 2016 / Revised: 28 January 2017 / Accepted: 31 January 2017 / Published: 8 February 2017
(This article belongs to the Collection Bioactive Compounds)
Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis. The new compounds were identified as (9R)-moracin P 3′-O-α-l-arabinopyranoside (1), (9R)-moracin P 9-O-β-d-glucopyranoside (2), (9R)-moracin P 3′-O-β-d-glucopyranoside (3), and (9R)-moracin O 10-O-β-d-glucopyranoside (4) based on the spectroscopic interpretation and chemical analysis. Three benzofuran-type stilbenes, moracin O (5), R (7), and P (8) showed significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells. In addition, moracin O (5) and P (8) also demonstrated a remarkable inhibition of the acetic acid-induced pain. The molecular docking with metabotropic glutamate receptor 1 (mGluR1) results indicated that these neuroprotective benzofuran-type stilbenes might be the active analgesic components of the genus Morus, and acted by mediating the mGluR1 pathway. View Full-Text
Keywords: benzofuran-type stilbenes; neuroprotection; analgesia; Cortex Mori Radicis benzofuran-type stilbenes; neuroprotection; analgesia; Cortex Mori Radicis
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MDPI and ACS Style

Wang, Y.-N.; Liu, M.-F.; Hou, W.-Z.; Xu, R.-M.; Gao, J.; Lu, A.-Q.; Xie, M.-P.; Li, L.; Zhang, J.-J.; Peng, Y.; Ma, L.-L.; Wang, X.-L.; Shi, J.-G.; Wang, S.-J. Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1. Molecules 2017, 22, 236. https://doi.org/10.3390/molecules22020236

AMA Style

Wang Y-N, Liu M-F, Hou W-Z, Xu R-M, Gao J, Lu A-Q, Xie M-P, Li L, Zhang J-J, Peng Y, Ma L-L, Wang X-L, Shi J-G, Wang S-J. Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1. Molecules. 2017; 22(2):236. https://doi.org/10.3390/molecules22020236

Chicago/Turabian Style

Wang, Ya-Nan; Liu, Mao-Feng; Hou, Wei-Zhen; Xu, Rui-Ming; Gao, Jie; Lu, An-Qi; Xie, Mei-Ping; Li, Lan; Zhang, Jian-Jun; Peng, Ying; Ma, Li-Li; Wang, Xiao-Liang; Shi, Jian-Gong; Wang, Su-Juan. 2017. "Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR1" Molecules 22, no. 2: 236. https://doi.org/10.3390/molecules22020236

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