Special Issues

Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cell and Gene-Based Therapies for HIV
edited by
submission deadline 31 Dec 2026 | Viewed by 176 | Submission Open
Keywords: HIV cure strategies; gene editing; CAR-T cells; viral reservoir; stem cell transplantation
(This special issue belongs to the Section Human Virology and Viral Diseases)
Epstein–Barr Virus: Mechanisms in Autoimmunity and Oncogenesis
edited by Elliott SoRelle
submission deadline 31 Dec 2026 | Viewed by 166 | Submission Open
Keywords: Epstein– Barr virus (EBV); host– virus interactions; autoimmunity; inflammatory responses; viral oncogenesis; multiple sclerosis (MS); systemic lupus erythematosus (SLE); Burkitt lymphoma (BL); lymphoproliferative disorders (LPD); primary effusion lymphoma (PEL); extranodal NK/T cell lymphoma (ENKTL); nasopharyngeal carcinoma (NPC); gastric carcinoma (GC); chronic active EBV (CAEBV); hemophagocytic lymphohistiocytosis (HLH)
(This special issue belongs to the Section Human Virology and Viral Diseases)
Pathogenesis and Pathology of Equine Viral Infections submission deadline 31 Dec 2026 | Viewed by 165 | Submission Open
Keywords: equine viruses; equine pathology; viral pathogenesis; immunopathology; tissue tropism; organ-system pathology; host– virus interactions; diagnostic pathology; molecular pathology; horses/equids; viral diseases/veterinary virology
(This special issue belongs to the Section Animal Viruses)
Innovations and Emerging Challenges in Hepatitis C Virus Research
edited by and Jens Bukh
submission deadline 31 Dec 2026 | Viewed by 128 | Submission Open
Keywords: hepatitis C virus (HCV); direct-acting antivirals (DAAs); antiviral drug development; antiviral resistance; pathogenesis models; viral life cycle; host– pathogen interactions; immunology; innate and adaptive immune responses; vaccine research; global elimination strategies; molecular virology; cell culture studies; animal model studies; epidemiology and public health
(This special issue belongs to the Section Human Virology and Viral Diseases)
The Role of Bacteriophages in Salmonella Diversity, Pathogenicity and Surveillance
edited by , Yan Gao and Shengyi Han
submission deadline 31 Dec 2026 | Viewed by 114 | Submission Open
Keywords: bacteriophages; Salmonella; structural virology; prophage; antimicrobial resistance; phage typing; gene editing; genome evolution; phage therapy
(This special issue belongs to the Section Bacterial Viruses)
Basophils and Mast Cells in Respiratory Viral Pathogenesis submission deadline 31 Dec 2026 | Viewed by 79 | Submission Open
Keywords: respiratory viruses; mast cells; basophils; degranulation; antiviral response; pathology; respiratory virus immunology; immunotherapy
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Biotechnological Applications of Extremophile Bacteriophages
edited by
submission deadline 31 Dec 2026 | Viewed by 54 | Submission Open
Keywords: thermophile; thermophage; thermophilic bacteriophage; extremophile; Geobacillus; Thermus; Archeae; hot spring; geothermal vent
(This special issue belongs to the Section Bacterial Viruses)
HIV and HTLV Infections and Coinfections (2nd Edition) submission deadline 1 Jan 2027 | 1 articles | Viewed by 1008 | Submission Open
Keywords: HTLV; HIV; infection; co-infection
(This special issue belongs to the Section Human Virology and Viral Diseases)
Avian Viruses and Antiviral Immunity
edited by and
submission deadline 15 Jan 2027 | 8 articles | Viewed by 6205 | Submission Open
Keywords: avian viruses; antiviral immunity; pathogenic mechanism; vaccine development; antiviral drugs; epidemiological dynamics; prevention and control; viral diseases of poultry and wild birds 
(This special issue belongs to the Section Animal Viruses)
Vaccines and Therapeutics Against Orthoflaviviruses
edited by and Liang Qiao
submission deadline 28 Jan 2027 | Viewed by 185 | Submission Open
Keywords: orthoflaviruses; vaccines; immunity; therapeutic agents; neutralizing antibodies; animal models; pathogenesis; protective efficacy
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Hepatitis Virus Genetic Heterogeneity: Impact in Epidemiology and Clinical Pathology
edited by , and Diego Flichman
submission deadline 31 Jan 2027 | 1 articles | Viewed by 1970 | Submission Open
Keywords: viral hepatitis; molecular diagnostics; genotyping; molecular epidemiology; antiviral therapy; drug resistance; genomic surveillance
(This special issue belongs to the Section Human Virology and Viral Diseases)
Viral Non-Structural Proteins
edited by
submission deadline 31 Jan 2027 | Viewed by 700 | Submission Open
Keywords: viral genome; non-structural proteins; virus replication; vaccines; viral therapeutics
(This special issue belongs to the Section General Virology)
Adenovirus Cell and Immune Interactions 2026
edited by
submission deadline 31 Jan 2027 | Viewed by 290 | Submission Open
Keywords: adenovirus; gene therapy; vaccine; immune system; respiratory disease; structure
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Antiviral Protease Inhibitors
edited by Xufang Deng and
submission deadline 31 Jan 2027 | Viewed by 277 | Submission Open
Keywords: antiviral drug discovery; high-throughput screen; structure-guided drug design; artificial intelligence (AI)-based drug discovery; drug resistance; combination therapies; antiviral assay development; host-targeting antiviral
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Filoviruses: Pathogenesis, Immunity, and Countermeasures
edited by
submission deadline 31 Jan 2027 | Viewed by 173 | Submission Open
Keywords: filoviruses; ebola virus (EBOV); marburg virus (MARV); taï forest virus (TAFV); sudan virus (SUDV); reston virus (RESTV); bombali virus (BOMV); bundibugyo virus (BDBV); cytokine storm; viral pathogenesis; immunity; countermeasures; type-I interferons; inflammatory cytokines
(This special issue belongs to the Section Animal Viruses)
Viral Immune Evasion and Host Defense: Mechanisms and Therapeutic Targets submission deadline 31 Jan 2027 | Viewed by 133 | Submission Open
Keywords: viral immune evasion; host antiviral defense; emerging and re-emerging viruses; innate immune signaling; targeted antiviral therapies
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Impact of Evolution on Herpesvirus Pathogenesis
edited by
submission deadline 31 Jan 2027 | Viewed by 105 | Submission Open
Keywords: herpesviruses; evolution; pathogenesis
(This special issue belongs to the Section Human Virology and Viral Diseases)
Phage Ecology and Evolution in Animal Health
edited by
submission deadline 31 Jan 2027 | Viewed by 98 | Submission Open
Keywords: antimicrobial resistance; host– microbe interactions; phage ecology; phage evolution; veterinary microbiology
(This special issue belongs to the Section Bacterial Viruses)
Flaviviridae: Advances in Diagnosis, Prevention, and Control Strategies
edited by
submission deadline 31 Jan 2027 | Viewed by 61 | Submission Open
Keywords: flaviviridae; dengue virus; Zika virus; virus– host interactions; antiviral strategies; host-directed therapy; viral pathogenesis; emerging viruses
(This special issue belongs to the Section Animal Viruses)
Animal Herpesvirus: 3rd Edition
edited by
submission deadline 31 Jan 2027 | Viewed by 57 | Submission Open
Keywords: herpesviruses; innate immune responses; host adaptive immune responses; herpesvirus-host; interactions; susceptibility
(This special issue belongs to the Section Animal Viruses)
Molecular Mechanisms and Clinical Manifestations of Persistent Viral Infections (2nd Edition)
edited by and Simone La Frazia
submission deadline 1 Feb 2027 | Viewed by 208 | Submission Open
Keywords: mammalian viruses; chronic infection; latent infection; HIV; HPV; HBV; HCV; HSV; pathogenetic mechanisms; molecular pathways; oncogenic processes; immunity; antiviral drugs; endogenous viral element
(This special issue belongs to the Section Human Virology and Viral Diseases)
Insect-Specific Viruses and Biological Control of Arboviruses submission deadline 6 Feb 2027 | 1 articles | Viewed by 1846 | Submission Open
Keywords: insect-specific virus; mosquito-specific virus; arbovirus; evolution; vaccine; biological control; interference
(This special issue belongs to the Section Invertebrate Viruses)
Viral Entry and Membrane Fusion
edited by Fabiana Carneiro
submission deadline 16 Feb 2027 | Viewed by 217 | Submission Open
Keywords: viral entry; membrane fusion; virus– host interactions; endocytosis; antiviral strategies
(This special issue belongs to the Section General Virology)
Viral Infections in Hematopoietic Stem Cell Transplant and Cellular Therapy Recipients, 2nd Edition
edited by Sanjeet Singh Dadwal
submission deadline 26 Feb 2027 | Viewed by 337 | Submission Open
Keywords: HSCT; GVHD; HHV6; CMV; adenovirus; BK and JC virus (polyomaviruses); HIV
(This special issue belongs to the Section Human Virology and Viral Diseases)
Plant Viral Pathogens: Innovations in Detection, Genetic Diversity, and Evolutionary Dynamics
edited by
submission deadline 28 Feb 2027 | 4 articles | Viewed by 6151 | Submission Open
Keywords: high-throughput sequencing; RT-PCR and qRT-PCR; genetic diversity; virus evolution; mutations; reassortment; recombination
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Emerging and Reemerging Plant Viruses in a Changing World: 2nd Edition
edited by
submission deadline 28 Feb 2027 | 3 articles | Viewed by 2580 | Submission Open
Keywords: emerging and re-emerging viruses; virus spillover; climate change and global trade; mixed infections; plant– virus– vector relationships
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Innovative Prophylactic and Therapeutics for the Treatment of Coronavirus Infection
edited by and Jun-Gyu Park
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2489 | Submission Open
Keywords: prophylactic; therapeutics; SARS-CoV-2; viral variants; antivirals
(This special issue belongs to the Section Coronaviruses)
Cellular Mechanisms Regulating HIV Replication, 2nd Edition
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1902 | Submission Open
Keywords: HIV-1; HIV-1 replication; host factors
(This special issue belongs to the Section Human Virology and Viral Diseases)
Application of Genetically Engineered Plant Viruses, 2nd Edition
edited by and Chu-Hui Chiang
submission deadline 28 Feb 2027 | 1 articles | Viewed by 921 | Submission Open
Keywords: plant virus; infectious clone; viral vector; virus-induced gene silencing (VIGS); virus-like particles (VLPs); cross-protection
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Immune Mechanisms Against Respiratory Viral Pathogens
edited by Telugu Akula Narasaraju and Sunil More
submission deadline 28 Feb 2027 | Viewed by 337 | Submission Open
Keywords: respiratory viral infections; innate and adaptive immunity; host– pathogen interactions; inflammatory response; therapeutic interventions
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Acute and Persistent Immune Responses to Respiratory Infections and Vaccines—Mucosal and Systemic
edited by Julian Tang
submission deadline 28 Feb 2027 | Viewed by 250 | Submission Open
Keywords: respiratory viruses; coronaviruses; SARS-CoV-2; influenza; parainfluenza; RSV (respiratory syncytial virus); adenoviruses; rhinoviruses; enteroviruses; host immune responses; mucosal immunity; systemic immunity; clinical disease severity; virus transmission; infection control; vaccine responses
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viral Pneumonia: Recent Advances and Prospects
edited by
submission deadline 31 Mar 2027 | Viewed by 450 | Submission Open
Keywords: viral pneumonia; viral lung infections; respiratory viruses; influenza viruses; respiratory syncytial virus (RSV); coronaviruses (such as SARS-CoV-2); viral persistence; molecular mechanisms; host immune responses; innate and adaptive immunity; immune– metabolic interactions; alveolar regeneration; dysregulated inflammation; epithelial and endothelial repair mechanisms; single-cell omics; organoid models; spatial profiling
(This special issue belongs to the Section General Virology)
New Advances in Small Ruminant Lentiviruses: Genetic Variability, Diagnostic Challenges, and Control Strategies
edited by and
submission deadline 31 Mar 2027 | Viewed by 222 | Submission Open
Keywords: caprine arthritis encephalitis virus (CAEV); cross-species transmission; control and Eradication program; genetic variability; Maedi-Visna virus (MVV); molecular diagnosis; pathology; serological assays; small ruminant lentiviruses (SRLV); wildlife reservoirs
(This special issue belongs to the Section Animal Viruses)
Iridoviruses, 3rd Edition submission deadline 31 Mar 2027 | Viewed by 219 | Submission Open
Keywords: iridovirus; viral immune evasion; anti-viral immune responses; viral vaccine; viral pathogenesis; viral epidemiology
(This special issue belongs to the Section Animal Viruses)
Virioplankton and Climate Change
edited by
submission deadline 31 Mar 2027 | Viewed by 164 | Submission Open
Keywords: viruses; climate change; bacteriophages; viral shunt; bacteria; picophytoplankton
(This special issue belongs to the Section Bacterial Viruses)
Human T Cell Leukemia Virus
edited by
submission deadline 31 Mar 2027 | Viewed by 85 | Submission Open
Keywords: infection prevention; vaccines; anti-viral drugs to prevent infection; measures against prejudice and discrimination; public health initiatives; risk evaluation by biomarkers; early therapeutic intervention; new treatment strategies
(This special issue belongs to the Section Human Virology and Viral Diseases)
Molecular Mechanisms and Structural Biology of High-Pathogenicity RNA Viruses submission deadline 31 Mar 2027 | Viewed by 77 | Submission Open
Keywords: high-pathogenicity RNA viruses; structural virology; virus– host interactions; viral replication complexes; intrinsically disordered proteins; cryo-electron microscopy; immune evasion mechanisms; viral protein structure; phase separation in viral infection; antiviral target discovery
(This special issue belongs to the Section General Virology)
HIV Reservoirs, Latency, and the Factors Responsible (2nd Edition)
edited by Yuyang Tang and
submission deadline 1 Apr 2027 | Viewed by 39 | Submission Open
Keywords: HIV; reservoirs; HIV latency; persistence; HIV eradication; HIV cure; HIV vaccines
(This special issue belongs to the Section Human Virology and Viral Diseases)
The Interplay Between Viral Infections and Autoimmune Diseases
edited by
submission deadline 30 Apr 2027 | 2 articles | Viewed by 3033 | Submission Open
Keywords: viral infections; autoimmune diseases; molecular mimicry; epitope spreading; persistent antigen & tissue‐specific antiviral responses; biomarkers & precision stratification; vaccine-related immune dynamics; single-cell & spatial omics; post-viral syndromes; immune repertoire; immune-repertoire alteration syndrome
(This special issue belongs to the Section Human Virology and Viral Diseases)
Spectroscopic Advances in Virology: Technique Development and Applications to Viral Structure and Function
edited by
submission deadline 30 Apr 2027 | Viewed by 102 | Submission Open
Keywords: viral dynamics; structural virology; biophysical methods; nuclear magnetic resonance; fluorescence spectroscopy; electron paramagnetic resonance; virus– host interaction; antiviral design
(This special issue belongs to the Section General Virology)
Antiviral Agents and Peptides: Discovery, Mechanisms, and Therapeutic Applications
edited by
submission deadline 30 Apr 2027 | Viewed by 57 | Submission Open
Keywords: antiviral agents; antiviral peptides (AVPs); drug discovery; drug resistance; peptide engineering; mechanisms of antiviral action; structure– activity relationship (SAR); high-throughput screening; AI-assisted design
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Innate and Mucosal Immunity Against Viral Infections
edited by
submission deadline 30 Apr 2027 | Viewed by 31 | Submission Open
Keywords: viral infection; innate immunity; mucosal immunity; adjuvant; immune escape; mucosal barrier; innate signaling pathway; immunopathogenesis; viral immune defense
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viral Genetic Variability and Its Role in Assessing Infectious Diseases submission deadline 6 May 2027 | 2 articles | Viewed by 3620 | Submission Open
Keywords: viral genetic diversity; infectious diseases; viral evolution; host adaptation; next-generation sequencing; pathogenicity; immune evasion; viral surveillance; bioinformatics; genetic variability; phylogeny; phylodynamics
(This special issue belongs to the Section General Virology)
Viruses in Extreme Environments
edited by Julian Tang and Tze Ping Loh
submission deadline 31 May 2027 | 2 articles | Viewed by 2117 | Submission Open
Keywords: extreme cold  ; extreme heat  ; extreme pressure  ; microgravity  ; radiation  ; space  ; virus survival
(This special issue belongs to the Section General Virology)
Highly Virulent Viruses: From Pathogenesis to Therapeutics
edited by Lorenzo Subissi and M. Kariuki Njenga
submission deadline 31 May 2027 | Viewed by 147 | Submission Open
Keywords: highly virulent viruses; molecular pathogenesis; host– virus interactions; medical countermeasures
(This special issue belongs to the Section General Virology)
Virus–Host Protein Interactions, 2nd Edition
edited by
submission deadline 31 May 2027 | Viewed by 110 | Submission Open
Keywords: virus–host interactions; protein–protein interactions; viral proteins; antiviral drug discovery; protein target inhibitors
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viral Capsids: Structural and Functional Implications
edited by
submission deadline 31 May 2027 | Viewed by 63 | Submission Open
Keywords: viral capsid assembly and disassembly; structural virology; capsid– host interactions; viral genome packaging and uncoating; antiviral targets and therapeutics; vaccine development and neutralizing antibodies; capsid maturation and dynamics
(This special issue belongs to the Section General Virology)
Rational Antiviral Therapy: Targeting Viral and Host Determinants for Optimized Treatment submission deadline 30 Jun 2027 | Viewed by 66 | Submission Open
Keywords: precision antiviral therapy; virus– host interactions; host-directed antivirals; antiviral resistance mechanisms; targeted antiviral delivery; omics-driven antiviral strategies
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Structure, Function, and Inhibition of HIV Proteins: Advances in Therapeutic Targets and Drug Discovery submission deadline 31 Jul 2027 | Viewed by 81 | Submission Open
Keywords: HIV; AIDS; HIV proteins; protein structure and function; enzymatic mechanisms; therapeutic targets; drug discovery; protein inhibition; structure-based drug design; antiretroviral therapy
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Addressing Key Viral Threats in South Africa: HIV, Respiratory Viruses, and Emerging Pathogens
edited by
submission deadline 1 Aug 2027 | Viewed by 163 | Submission Open
Keywords: emerging and zoonotic viruses; HIV; SARS-CoV-2; RSV; HBV; HCV; diagnostics and surveillance; CMV; vaccine development
(This special issue belongs to the Section General Virology)
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