Mechanisms of Herpesvirus Resistance
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 1777
Special Issue Editor
Interests: virology; DNA viruses; antivirals; drug resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Herpesviruses are common human pathogens, generally causing mild to asymptomatic infections in immunocompetent hosts. However, human herpesvirus infections are more serious when the host has a weak immune system, causing significant morbidity and mortality among different populations of immunocompromised hosts. An important feature of all herpesviruses is their ability to establish lifelong latent infections after a primary infection, remaining dormant. Reactivation of herpesviruses often occurs when the immune system is impaired, causing life-threatening persistent infections that require prolonged treatment. Such prolonged treatment coupled with an impaired immune system provides the perfect selective landscape for the emergence and selection of drug-resistant mutants. Herpesviruses bearing mutations in genes associated with drug resistance can cause severe infections and extreme discomfort and eventually death among immunocompromised patients. Drug resistance is also increasingly being recognized in immunocompetent individuals suffering from herpetic keratitis.
This Special Issue of Viruses will focus on the latest advances in understanding the mechanism of herpesvirus drug resistance for the different classes of anti-herpesvirus drugs, encompassing in vitro, in vivo, and clinical research. We will also delve into the diagnosis of herpesvirus drug resistance as well as the development of new drugs and strategies to manage drug-resistant herpesvirus infections in the clinic. We invite you to share your most insightful primary research work, reviews, and hypotheses on these important topics.
Prof. Dr. Graciela Andrei
Guest Editor
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Keywords
- human herpesviruses
- cytomegalovirus
- drug resistance
- antiviral agents
- immunocompromised host
- novel anti-herpesvirus therapies
- DNA polymerase
- terminase
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