Special Issue "Immunomodulatory Plants & Plant-Derived Immunomodulators"

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: 31 July 2020.

Special Issue Editors

Prof. Dr. Marcello Iriti
E-Mail Website
Guest Editor
Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy
Interests: crop protection; plant diseases; agrochemicals; abiotic stresses; food production; food security; food safety; global climate change; bioactive phytochemicals; agrochemicals; mycotoxins; medicinal plants; ethnobotany
Special Issues and Collections in MDPI journals
Dr. Elena Maria Varoni
E-Mail Website
Guest Editor
Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy
Interests: Oral diseases; Oral health; Bioactive Phytochemicals; Biomaterials; Nanomaterials; Drug delivery systems
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Modulation of immune system using medicinal herbs and phytochemicals represents a relatively novel and intriguing therapeutic approach for those diseases where immune response is involved. In their huge chemical diversity, plants as well as fungi (mushrooms) and algae contain secondary metabolites that modulate, i.e. stimulate or suppress, the host immune response. A number of traditional medicinal plants have been used as immunostimulants and immunosuppressants targeting various components or mediators of innate and adaptative immune response (phagocytosis, T and B lymphocytes, complement system, cytokines, chemokines, inflammatory mediators), such as Andrographis paniculata, Curcuma longa, Echinacea purpurea, Withania somnifera, Tinospora cordifolia, Ocimum sanctum, Azadirachta indica, Boswellia serrata, Momordica charantia, Panax ginseng and Boerhaavia diffusa. Immunomodulatory phytochemicals belong to different chemical classes, including alkaloids (berberine, chelerythrine, piperine), polyphenols (quercetin, rutin, apigenin, luteolin, epigallocatechin-3-gallate, daidzein, genistein, resveratrol) and isoprenoids (triptolide, 14-deoxyandrographolide, ginsan, oleanolic acid). In this view, herbal formulations represent promising immunomodulatory agents, even if their side-effects, interactions with drugs and bioavailability have to be taken into account.

Prof. Marcello Iriti
Dr. Elena Maria Varoni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • immunostimulants
  • immunomodulators
  • immunosuppressants
  • immunoadjuvants
  • medicinal plants
  • mushrooms
  • algae
  • bioactive phytochemicals
  • botanicals
  • traditional medicine
  • ethnobotany
  • ethnopharmacology

Published Papers

This special issue is now open for submission.
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