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Special Issue "Flavonoids"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Plant Sciences".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Prof. Dr. Marcello Iriti
Website
Guest Editor
Department of Agricultural and Environmental Sciences, Università degli Studi di Milano, Milan, Italy
Interests: phytochemicals; nutraceuticals; functional foods; medicinal plants; botanicals; bioactives; melatonin; food security; food safety; one health; global climate change; ethnobotany; ethnopharmacology
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Special Issue Information

Dear Colleagues,

Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ring (C). The main classes of flavonoids (flavonols, flavanols, flavones, flavanones, isoflavones and anthocyanidins) differ in the level of oxidation and saturation of the C ring, while individual compounds within a class vary in the substitution pattern of the A and B rings. In planta, they exert a plethora of ecological roles as variously colored pigments and signaling molecules, being involved in pollinator attraction and root symbioses, just to name a few examples. In addition, flavonoids protect plant from abiotic and biotic stressors, such as UV radiation and pathogen attack (in this context, they represent a group of phytoalexins). Health-promoting effects of traditional food and medicinal plants have been ascribed to their content in bioactive phytochemicals including flavonoids, also known as nutraceuticals. A huge number of in vitro/in vivo studies on animal and cell experimental models highlighted their preclinical efficacy as antioxidant, antimicrobial, anticancer/chemopreventive, antidiabetic, vasoprotective and vasodilating agents, in addition to their cardio- and neuroprotective effects. The flavonoid mechanism of action is directed toward multiple molecular and biochemical targets in prokaryotic and eukaryotic cells. Therefore, plant foods and herbal remedies are multitarget agents containing hundreds of flavonoids (including aglycones and glycosides) and other different phytochemicals. In this context, given the global threat of antimicrobial resistance, these phytotherapeutics have a low risk of selecting chemoresistant microbial and cancer cells. Flavonoids can also reverse chemoresistance (including multidrug resistance) modulating efflux pumps, and hence they can be used as adjuvant (or chemosensitizer) agents in conventional antimicrobial and anticancer therapies. Not least, flavonoids can mitigate age-associated cellular damage and extend lifespan as epigenetic modulators and by mimicking calorie restriction. Finally, oral bioavailability of flavonoids represents another relevant issue. Indeed, after ingestion, they are metabolized by phase I and II enzymes like other xenobiotics before reaching the target cells and tissues.

In this very wide context, we invite investigators to submit both original research and review articles that explore all these aspects.

Prof. Dr. Marcello Iriti
Dr. Elena Maria Varoni
Prof. Dr. Sara Vitalini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Flavonoid biosynthesis
  • Flavonoid gene expression
  • Plant abiotic stresses
  • Plant biotic stresses
  • Phytoalexins
  • Chemoecology
  • Ecophysiology
  • Functional foods
  • Medicinal plants & herbal remedies
  • Nutraceuticals
  • Antioxidant activity
  • Antimicrobial activity
  • Antimicrobial resistance
  • Anticancer activity
  • Cancer chemoprevention
  • Antidiabetic activity
  • Vasoprotection
  • Cardioprotection
  • Neuroprotection
  • Antiaging agents
  • Sirtuins
  • Oral diseases
  • Oral bioavailability
  • In human studies & randomized clinical studies

Published Papers (1 paper)

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Review

Open AccessReview
A Comprehensive Review on Chemotaxonomic and Phytochemical Aspects of Homoisoflavonoids, as Rare Flavonoid Derivatives
Int. J. Mol. Sci. 2021, 22(5), 2735; https://doi.org/10.3390/ijms22052735 - 08 Mar 2021
Viewed by 172
Abstract
Homoisoflavonoids (3-benzylidene-4-chromanones) are considered as an infrequent flavonoid class, possessing multi-beneficial bioactivities. The present study gives an overview on phytochemical aspects of homoisoflavonoids, including utilized plant species, parts, extracts, and separation techniques. Overall, these compounds have mainly been isolated and identified from bulbs [...] Read more.
Homoisoflavonoids (3-benzylidene-4-chromanones) are considered as an infrequent flavonoid class, possessing multi-beneficial bioactivities. The present study gives an overview on phytochemical aspects of homoisoflavonoids, including utilized plant species, parts, extracts, and separation techniques. Overall, these compounds have mainly been isolated and identified from bulbs and rhizomes of the plants belonging to Asparagaceae and Fabaceae families, particularly the genera of Ophiopogon, Dracaena, Scilla, Polygonatum, and Caesalpinia. Full article
(This article belongs to the Special Issue Flavonoids)
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