Special Issue "Antimicrobial Agents in Oral Diseases: Prophylaxis and Therapy between New and Old Molecules"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics of Drugs".

Deadline for manuscript submissions: 31 August 2022.

Special Issue Editor

Prof. Dr. Elena Maria Varoni
E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

Antibiotic resistance represents a huge problem that the scientific community is called upon to tackle as a matter of priority. The Centers for Disease Control and Prevention reports that, each year, 2.8 million Americans experience an antibiotic-resistant infection, with the death of more than 35,000 people.

Safeguarding the effectiveness of old antimicrobial agents is fundamental today, as is the need to discover new ones. Studies will be pivotal to further elucidate the mechanism of action of old molecules to better understand, counteract, and prevent the spread of resistant bacteria. Research is also aimed at identifying new ones as well as proposing molecules which are capable of acting as adjuvants.

Common oral diseases (e.g., orofacial infection, periodontitis) in particular are treated using the support of antibiotics and antiseptics, representing the most prescribed medications by dentists, who are, thus, called to the fore to fight inappropriate prescriptions in their routine practice.

This Special Issue will publish papers focusing on the management of oral diseases with a particular focus on the activity of old and new antiseptics and antibiotics, on the use of these medications in dental setting, and on the education of dental professionals regarding their correct prescription.

Dr. Elena Maria Varoni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antibiotics
  • Antiseptics
  • Oral Medicine
  • Periodontology
  • Oral Infections

Published Papers (1 paper)

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Research

Article
Activity of Two Antimicrobial Peptides against Enterococcus faecalis in a Model of Biofilm-Mediated Endodontic Infection
Antibiotics 2021, 10(10), 1220; https://doi.org/10.3390/antibiotics10101220 - 07 Oct 2021
Viewed by 445
Abstract
Enterococcus faecalis is a common cause of biofilm-associated opportunistic infections, which are often difficult to treat. The formation of E. faecalis biofilms on the dentinal walls of the root canal is frequently the cause of endodontic treatment failure and secondary apical periodontitis. In [...] Read more.
Enterococcus faecalis is a common cause of biofilm-associated opportunistic infections, which are often difficult to treat. The formation of E. faecalis biofilms on the dentinal walls of the root canal is frequently the cause of endodontic treatment failure and secondary apical periodontitis. In a preliminary work, two recognized antifungal peptides, KP and L18R, showed antibacterial activity against planktonic E. faecalis cells at micromolar concentrations. Moreover, L18R proved to reduce the biomass in the early stage of E. faecalis biofilm development on polystyrene plates, while a qualitative biofilm inhibition was demonstrated on hydroxyapatite disks by confocal laser scanning microscopy (CLSM). The aim of this study was to better characterize the effect of both peptides on E. faecalis biofilm. A reduction in metabolic activity after peptide treatment was detected by Alamar Blue assay, while a remarkable impairment in the architecture of E. faecalis biofilms on hydroxyapatite disks, along with a significant reduction in viable bacteria, was caused mostly by L18R, as assessed by CLSM and scanning electron microscopy. The lack of cytotoxicity of the investigated peptides against L929 murine fibroblasts was also determined. Obtained results suggest L18R as a promising candidate for the development of new strategies for endodontic infection control. Full article
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