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Toxins
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Development and Validation of Analytical Methods for the Determination of...
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Development and Validation of Analytical Methods for the Determination of Mycotoxins

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 5447

Special Issue Editor

Prof. Dr. Laura Anfossi

E-Mail Website
Guest Editor
Department of Chemistry, Universita degli Studi di Torino, 10124 Torino, Italy
Interests: analytical chemistry; immunochemical assays; food chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Mycotoxins are compounds produced by the secondary metabolites of fungi. As such, this group of compounds includes a large number of very different chemical compounds. Most mycotoxins have harmful effects on human and animal health, and represent a serious hazard that has been recognized by regulations on food and feed quality and safety worldwide. Mycotoxins are produced during fungal growth on plants and grains; however, post-harvesting contamination has been frequently reported. They are generally resistant to thermal and acidic treatments and thus enter the food chain and are able to persist and even to transfer to food of animal origin due to their metabolization. The chemical difference and the variety of commodities in which mycotoxins are spread both represent a challenge to modern analytical techniques. Furthermore, their high toxicity requires highly sensitive approaches to effectively control food safety. This Special Issue will encompass all aspects of new strategies for the efficient determination of mycotoxins, such as extraction from substrates, separation, and detection. Rapid testing and screening strategies to monitor mycotoxins will be considered, including sensors, biosensors, and methods exploiting new nanomaterials and nanotechnologies. Hyphenated techniques and high-throughput methods enabling the accurate and multiplexing determination of several classes of mycotoxins and the unveiling of new and unknown compounds will be also considered. Methods addressing the fate of mycotoxins and their transformation by plant, animal, and human metabolism will also be included, as well as new analytical approaches focused on mycotoxin detection in unconventional matrices. Special focus will be devoted to the validation aspects of emerging analytical methods.

Prof. Laura Anfossi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sensors
  • biosensors
  • nanomaterials
  • nanotechnology
  • extraction
  • high-throughput methods
  • multiplexing
  • masked toxins
  • biomarkers of exposure

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Published Papers (1 paper)

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Research

13 pages, 1050 KiB  
Article
Simultaneous Quantification of Aflatoxin B1, T-2 Toxin, Ochratoxin A and Deoxynivalenol in Dried Seafood Products by LC-MS/MS
by Yijia Deng, Yaling Wang, Qi Deng, Lijun Sun, Rundong Wang, Xiaobo Wang, Jianmeng Liao and Ravi Gooneratne
Toxins 2020, 12(8), 488; https://doi.org/10.3390/toxins12080488 - 30 Jul 2020
Cited by 32 | Viewed by 4550
Abstract
Mycotoxins are secondary metabolites produced by fungi. These contaminate dried seafoods during processing and storage and represent a potential health hazard for consumers. A sensitive, selective and accurate liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was established for simultaneous quantification of four common mycotoxins [...] Read more.
Mycotoxins are secondary metabolites produced by fungi. These contaminate dried seafoods during processing and storage and represent a potential health hazard for consumers. A sensitive, selective and accurate liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was established for simultaneous quantification of four common mycotoxins (aflatoxin B1 (AFB1), T-2 toxin (T-2), ochratoxin A (OTA) and deoxynivalenol (DON)) in dried shrimp, dried fish and dried mussel products. Mycotoxins were extracted from dried seafood samples by acetonitrile/water (85/15, v/v), subjected to ultrasound for 60 min at 20 °C and cleaned up by defatting with n-hexane. The sample matrix affected the linearity of detection (R2 ≥ 0.9974). The limit of detection (LOD) and limit of quantification (LOQ) in dried seafood products varied from 0.1 to 2.0 µg·kg−1 and 0.3 to 5.0 µg·kg−1, respectively. The method was validated by spiking samples with specific mycotoxin levels, and the recoveries, intra-relative standard deviation (RSDs) and inter-RSDs ranged between 72.2–98.4%, 2.8–10.6%, and 5.5–15.4%, respectively. This method was used to analyze 40 dried seafood products purchased from the Zhanjiang seafood market. Results of this product sampling showed that while no DON was detected, AFB1, T-2 and OTA were detected in 30.8%, 17.5% and 33.3% of the samples, respectively. AFB1, T-2 and OTA concentrations varied at 0.58–0.89, 0.55–1.34 and 0.36–1.51 µg·kg−1, respectively. Relatively high frequency of contamination and the presence of AFB1, OTA and T-2 residues indicate the need to monitor mycotoxins in dried seafood products. Full article
(This article belongs to the Special Issue Development and Validation of Analytical Methods for the Determination of Mycotoxins)
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