Clinical Application of Botulinum Toxin 2.0
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 9420
Special Issue Editor
Interests: movement disorders; botulinum toxin; autonomic disorders; neurophysiology; neuroimaging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This is a second adaptation of the previous Special Issue, which attracted several papers on the clinical use of botulinum toxin. This Special Issue also intends to unite papers on such a topic. Botulinum toxin, the most potent biological toxin, has become a powerful therapeutic tool for a growing number of clinical applications. It has been approved for many disorders (including movement disorders and autonomic disorders (i.e., secretory and bladder)), pain, and ophthalmologic uses. Among movement disorders, it has revolutionized the treatment of focal spasticity of upper and lower limbs, focal dystonias, and some other rare conditions. In spasticity and dystonia, the mode of action of botulinum toxin is complex and is not only based on a blockage of acetylcholine release at the neuromuscular junction, leading to muscle weakness. Due to its effect on muscle spindles, it exerts an additional effect on different pathways to the central nervous system, thereby markedly contributing to beneficial clinical effects. There is increasing evidence that treatment outcomes can be optimized using guided injection techniques.
This Special Issue of Toxins explores the botulinum toxin treatment of movement disorders, in all its aspects, including treatment outcomes in focal spasticity, dystonias, tremors, and other movement disorders; the effects of different serotypes; dosing and side effects; antigenicity; evidence-based medicine; guided injection techniques (ultrasound, EMG, stimulation, and imaging); sensorimotor aspects of mode of action; and others.
Prof. Dr. Markus K. Naumann
Guest Editor
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Keywords
- botulinum toxin
- spasticity
- dystonia
- mode of action
- guidance
- outcome
- clinic therapy
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