Green and Scalable Bioprocess Engineering: Enzymatic Systems, Process Intensification and Sustainable Applications

Dear Colleagues,

The transition towards a bio-based and sustainable economy requires the development of efficient, scalable, and environmentally conscious bioprocesses. As industries seek alternatives to petroleum-based manufacturing, bioprocess engineering is a driving force behind the shift toward green and scalable manufacturing for the production of pharmaceuticals, bio-based chemicals, and value-added compounds.

Recent advances in enzymatic systems, process intensification, and upstream–downstream integration are enabling the development of greener and more robust bioprocesses. These innovations support both industrial and bio-pharmaceutical sectors, offering new pathways for the synthesis of therapeutic proteins, secondary metabolites, and specialty chemicals with reduced environmental impact.

This Special Issue on “Green and Scalable Bioprocess Engineering: Enzymatic Systems, Process Intensification and Sustainable Applications” aims to gather high-quality contributions that address the design, optimization, and scale-up of sustainable bioprocesses. We invite submissions that explore novel strategies in process development, biocatalysis, and bio-based production from a systems and engineering perspective.

Topics include, but are not limited to:

• Enzymatic biocatalysis for pharmaceutical and industrial applications
• Process intensification in fermentation and bioconversion systems
• Integration of upstream and downstream operations in continuous or semi-continuous modes
• Bioprocess scale-up and pilot-to-industrial implementation
• Green chemistry principles in bioprocess design and synthesis routes
• Valorization of renewable resources and biomass in the context of the bioeconomy
• Techno-economic and life-cycle assessments of sustainable bioprocesses
• Design of eco-efficient unit operations and bioreactor systems
• Application of sustainable solvents and low-impact raw materials

This Special Issue emphasizes the process and systems engineering dimension of bioprocess development. Both experimental and computational studies are welcome, particularly those that demonstrate a clear pathway toward greener, scalable, and industrially relevant biotechnological solutions.

We look forward to your contributions.

Dr. Carlos Ocampo-López
Dr. Margarita Ramirez-Carmona
Dr. Leidy Rendón-Castrillón
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.