Environmental and Biotechnological Regulation of Plant Secondary Metabolites

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Plant Molecular Biology".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 531

Editors


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Guest Editor
Faculdade de Ciências e Tecnologia, Faro, Portugal
Interests: elicitation; environmental; medicinal plants; secondary metabolism; plants and climate

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Guest Editor
MED–Mediterranean Institute for Agriculture, Environment and Development & CHANGE–Global Change and Sustainability Institute, Faculdade de Ciências e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal
Interests: plant bioactive compounds; bioactivity; essential oils; phenolic compounds; secondary metabolites; plant tissue culture; extraction; green solvents
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Special Issue Information

Dear Colleagues,

Plant secondary metabolites (SMs) play essential roles in mediating interactions between plants and their environment, contributing to defense, stress tolerance, and ecological communication. These compounds, belonging to diverse classes such as phenolics, terpenoids, and alkaloids, are shaped by complex regulatory networks that respond dynamically to environmental cues. In the context of global climate change, understanding how environmental factors, including UV radiation, temperature extremes, drought, salinity, and nutrient availability, modulate these biosynthetic pathways remains a central challenge in plant science.

At the same time, advances in biotechnology, including metabolic engineering, genome editing, elicitor technologies, and controlled-environment cultivation, are opening new opportunities to enhance or tailor SM production for applications in medicine, agriculture, nutrition, and other industries. Integrating ecological, physiological, molecular, and biotechnological approaches is crucial for uncovering the mechanisms that regulate metabolite accumulation and for developing sustainable strategies to exploit plant-derived compounds. 

This Special Issue welcomes original research and review articles that explore environmental regulation, molecular control, evolutionary aspects, and biotechnological manipulation of plant secondary metabolism. Studies employing omics tools, metabolic modeling, bioreactor systems, and sustainable production platforms are particularly encouraged. Through this collection, we aim to provide an interdisciplinary forum that advances our understanding of how plants synthesize, regulate, and adapt their chemical diversity in changing environments.

Dr. Ines Mansinhos
Dr. Sandra Gonçalves
Guest Editors

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Keywords

  • secondary metabolites
  • phytochemicals
  • abiotic stress
  • plant–environment interactions
  • elicitation
  • green extraction
  • biosynthetic pathways
  • omics approaches
  • metabolic engineering
  • sustainable production

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Published Papers (1 paper)

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Research

28 pages, 4077 KB  
Article
UV-B Radiation Triggers Phenolic Accumulation and Oxidative Stress Response in Lamiaceae Species: From Plant Defense to Green Dye Remediation
by Inês Mansinhos, Sandra Gonçalves, João Brás, Raquel Rodríguez-Solana, María José Aliaño Gonzalez, Bruno Medronho, Gema Pereira-Caro, José Manuel Moreno-Rojas and Anabela Romano
Plants 2026, 15(14), 2210; https://doi.org/10.3390/plants15142210 - 20 Jul 2026
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Abstract
The present study explores the impact of UV-B radiation on biochemical traits and phenolic profile of in vitro cultures (IC) and micropropagated plants (MP) of Lavandula viridis L’Hér and Thymus lotocephalus G. López and R. Morales. Two UV-B treatments were applied: a single [...] Read more.
The present study explores the impact of UV-B radiation on biochemical traits and phenolic profile of in vitro cultures (IC) and micropropagated plants (MP) of Lavandula viridis L’Hér and Thymus lotocephalus G. López and R. Morales. Two UV-B treatments were applied: a single 4 h exposure (UV-B 1) and repeated exposure over four consecutive days (UV-B 4). Additionally, the potential of phenolic-rich extracts loaded into alginate-based hydrogels for dye removal was also evaluated. UV-B exposure triggered oxidative stress in both species, particularly in MP, increasing hydrogen peroxide levels and lipid peroxidation, and affecting chlorophyll and carotenoid content. Both species responded by accumulating soluble sugars and phenolic compounds as a defense mechanism. Rosmarinic acid, the predominant phenolic compound, increased significantly under UV-B radiation in IC and MP. IC showed higher concentrations after UV-B 1 exposure, with L. viridis reaching 50.1 mg/g and T. lotocephalus 32.3 mg/g, increases of 16% and 41%, respectively, over the control. Polyphenol-loaded hydrogels showed high methylene blue adsorption efficiency, highlighting their potential as eco-friendly materials for wastewater treatment and environmental remediation. Optimal adsorption conditions were determined using Box–Behnken design and Response Surface Methodology, demonstrating the applicability of these natural hydrogels as sustainable and efficient materials for dye removal from contaminated wastewater. Full article
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