Lactoferrin in Biomedical Applications

Dear Colleagues,

Lactoferrin (Lf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and neutrophils, is a bridge between natural and adaptative immunity. Bovine Lf (bLf) has been commercialized as nutraceutical product, having been declared as a compound “Generally Recognized as Safe” by the FDA and as a dietary supplement by EFSA.

This Special Issue aims to highlight some of the most significant contributions to the biomedical applications of Lf derived from different species, including bLf, which has been applied both in vitro and in vivo.

The topics of interest include (but are not limited to) Lf applications against microbial infections, iron and inflammatory homeostasis disorders, as well as immunomodulatory, antioxidant, and anticancer activities, with particular focus on the physicochemical characterization of Lf. The Lf receptors and the relationship between Lf and microbiota are pivotal for mechanisms of action. The development of new technologies that aim to improve its bioavailability should be considered. Original papers and review articles on Lf functions are welcome.

Dr. Maria Pia Conte
Prof. Dr. Piera Valenti
Dr. Luigi Rosa
Guest Editors

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