Biopolymer-Based Nanosystem for Drug Delivery, 2nd Edition

Dear Colleagues,

The enhanced permeability and retention (EPR) effect was discovered more than three decades ago (Y. Matsumura, H. Maeda 1986). This discovery is now cited as sparkinf a new wave of nanomedicine-related innovations for tumor-targeted drug delivery, a new concept in cancer chemotherapy. As of now, more than 50 nanomedicine formulations have been approved for clinical use. In the anticancer agent class, the flagship formulation is the biopolymer-based drug Abraxane (nanoparticle albumin-bound paclitaxel). ADCs represent an anticancer class in which specific biopolymers serve as antibodies to target moieties when they are conjugated to a highly toxic warhead drug, making them an effective anticancer agent. These drugs combine chemotherapy and immunotherapy, providing improved patient outcomes. The encapsulation of other biopolymer ingredients, such as RNA and DNA, or, in other words, active biomacromolecular therapeutic agents, results in the formation of nanosystems. Nowadays, the priority is to develop new vaccines. Recently, nanoformulated vaccines saved the lives of hundreds millions of people during the COVID pandemic, a task that remains ongoing.

Researchers must find new appropriate biopolymers that are biodegradable, biocompatible, non-immunogenic, improve the bioavailability of active cargos, and protect the active ingredient in the bloodstream. Depending on the formulation involved, the nature of the release of the active ingredient is a key factor. The main value is the precise targetting of the “cargo” to the cancer cells and the avoidance of healthy cells. This goal can be achieved by developing nanoformulation systems. The economic strength of this subdivision within the pharmaceutical industry is well known. However, R&D innovation in the biotech sector requires more time and effort compared the required levels in other fields. This explains the necessity of considering the conclusions of a professional risk analysis.

Scientists are encouraged to send relevant research for submission in this Special Issue.

Prof. Dr. Ildikó Bácskay
Prof. Dr. János Borbély
Guest Editors

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