Focus on Antibiotics – New Challenges and Steps Forward in Discovery and Development

Dear Colleagues,

The design of new antibiotics is still considered the primary weapon in the fight against the growing phenomenon of bacterial resistance to known antibiotics. Pharmaceutical research is focused on new approaches that lead to novel successful compounds within a short time. A new trend is targeting old antibiotics and other compounds from various therapeutic classes for optimization and repositioning. Hybrid drugs that incorporate two active compounds into a single molecule could expand antibacterial activity and prevent bacterial resistance. Different metal complexes of antibiotics or other organic substances have already shown potential for antibacterial activity. Nanoparticles (e.g., silver nanoparticles) are very attractive in multiple medical applications. Thus, in the last decade, new classes of antibiotics have been sought. New types of compounds with antibacterial activity are in various research stages: proteic compounds, siderophores, quinoxolidinones, natural antibiotics, antibiotic resistance breakers, and others. This Special Issue aims to present the latest efforts towards the discovery of new antibiotics.

 

Prof. Dr. Aura Rusu
Prof. Dr. Valentina Uivarosi
Dr. Corneliu Tanase
Guest Editors

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