Solid Dispersions for Bioavailability Enhancement
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 12374
Special Issue Editor
Special Issue Information
Dear Colleagues,
I am pleased to invite you to contribute to this Special Issue intended to highlight new advances in solid dispersions for bioavailability enhancement. Solid dispersions (SDs) have gained considerable attention in recent years as one of the most promising approaches to enhance the bioavailability of poorly soluble drugs. SDs can be prepared using various techniques, such as spray-drying and hot melt extrusion, by dispersing a poorly soluble drug in a polymeric matrix, which prevents drug crystallization and enhances both the solubility and the dissolution rate.
This Special Issue aims to provide a comprehensive overview of the recent advances in the field of SDs for bioavailability enhancement covering the development, characterization, and evaluation of SDs, as well as their applications in drug delivery. The collection of articles will hopefully contribute to advancements in the field, and ultimately, the development of more effective and safe medicines for patients.
The Special Issue serves as a platform for researchers to present their latest findings and insights in this rapidly growing field and welcomes original research articles and reviews that cover various aspects of SDs for bioavailability enhancement including (but not limited to) the following:
- Development and optimization of SDs using various techniques;
- Physical and chemical characterization of SDs;
- Evaluation of the in vitro and in vivo performance of SDs;
- Mechanistic understanding of the behavior of SDs;
- Regulatory considerations and challenges in the development of SDs.
I look forward to receiving your contributions.
Dr. Matthias Manne Knopp
Guest Editor
Manuscript Submission Information
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Keywords
- solid dispersions
- bioavailability enhancement
- solubility enhancement
- supersaturation
- amorphous
- drug–polymer interactions
- physical stability
- in vivo pharmacokinetics
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