Design of Dosage Forms with Improved Biopharmaceutical Properties

Dear Colleagues,

The principal objective of any dosage form is to augment the high therapeutic activity, safety and low toxicity of the drug. Application of the effective dosage forms makes it possible to achieve the rapid onset of action following drug delivery; to improve pharmacologically important properties of the drugs such as aqueous solubility, dissolution rate, membrane permeability and bioavailability; to mask the undesirable taste or offensive odor of a drug substance; to provide drugs with predetermined rate and prolonged therapeutic effect; and to prepare drug products that are stable, effective and safe for consumption under specified suitable storage conditions. The desired dosage forms must have adequate metabolic stability so that the drug does not undergo excessive presystemic clearance and has a reasonable in vivo residence time. Thus, the design of dosage forms with appropriate and reliable in vivo performance is an important task of the pharmaceutical sciences. Structure–property relationships and testing in vitro and in vivo are essential to develop the proper dosage forms with improved properties.

Dr. Irina Terekhova
Dr. Nataliya Kochkina
Guest Editors

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