Polymeric Films as a Multipurpose Drug Delivery System: Application, Properties, Preparation and Evaluation

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 1283

Editors


E-Mail Website
Guest Editor
1. Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2. Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
Interests: 3D printing technology; multicomponent tablets; personalized medicine; drug release profile; nanomaterials in pharmaceutical forms; chitosan-based formulations
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania
Interests: drug delivery systems; herbal compounds; dosage forms; dental application

Special Issue Information

Dear Colleagues,

In recent years, owing to their multipurpose properties, polymeric films as drug delivery systems have received a great deal of attention. This dosage form is universal, as it can have both local and systemic effects by application to the skin or mucous membrane (eyes, oral cavity, vaginal canal, etc.). Using different types of polymers and their combinations, it is possible to achieve different film thicknesses, its textural characteristics (elasticity, plasticity, adhesion, etc.), ensure prolonged contact with the target area, and controlled release of active agents. Polymeric films can be manufactured using various techniques, such as solvent casting, hot-melt extrusion, electrospinning, and 3D printing. The production, study of properties, and evaluation of polymeric films as drug delivery systems will give the opportunity to apply them for a wide range of therapeutic purposes.

This Special Issue aims to collect advanced studies on the production and evaluation of polymeric films as drug delivery systems using the previously mentioned and other methods. We welcome submissions of original research articles and review articles that contribute to the advancement of knowledge in this field.

We look forward to receiving your contributions.

Prof. Dr. Jurga Bernatoniene
Dr. Yuliia Maslii
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery system
  • polymers
  • polymeric films
  • physicochemical and texture characteristics
  • film production techniques
  • controlled and sustained release
  • adhesion
  • bioavailability
  • formulation
  • evaluation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

33 pages, 15142 KB  
Article
Influence of Fabrication Techniques on the Physicochemical, Textural, Release and Skin Delivery Performance of Polyvinyl Alcohol-Based Transdermal Films Containing Menthol: A Comparative Study
by Gintaras Matulis, Yuliia Maslii, Nataliia Herbina, Mindaugas Marksa, Agnė Mazurkevičiūtė and Jurga Bernatoniene
Pharmaceutics 2026, 18(7), 871; https://doi.org/10.3390/pharmaceutics18070871 - 16 Jul 2026
Viewed by 502
Abstract
Background: Transdermal films are promising dosage forms for controlled delivery of active pharmaceutical ingredients through the skin. Polyvinyl alcohol (PVA)-based matrices are particularly attractive due to their biocompatibility, film-forming ability, and versatility. However, the development of films for volatile compounds such as menthol [...] Read more.
Background: Transdermal films are promising dosage forms for controlled delivery of active pharmaceutical ingredients through the skin. Polyvinyl alcohol (PVA)-based matrices are particularly attractive due to their biocompatibility, film-forming ability, and versatility. However, the development of films for volatile compounds such as menthol remains challenging due to high potential losses during processing and application. This study compares PVA-based transdermal films fabricated by 3D printing, solvent casting, and electrospinning, focusing on the effect of fabrication method on film properties, release behaviour, and skin delivery performance. Methods: A comprehensive characterization included morphology, structure, thickness, moisture content, mechanical properties, adhesion, menthol content, in vitro release, ex vivo permeation, and stability. Results: Fabrication method significantly influenced film microstructure, menthol entrapment, and stability. Menthol acted as a plasticiser, increasing thickness and moisture content while reducing mechanical strength via disruption of intermolecular interactions within the PVA matrix. The 3D-printed films exhibited the highest entrapment efficiency (14.40%, corresponding to 4.00% menthol content in the dried matrix) and superior menthol retention after 6 months (75.0%), compared to solvent-cast and electrospun films, due to their dense layered structure limiting volatile losses. All formulations showed biphasic release behaviour, strongly dependent on fabrication method. Electrospun films released menthol fastest (68.94% at 1 h), followed by solvent-cast films (63.48% at 1 h), whereas 3D-printed films exhibited a more sustained profile (46.14% at 2 h), reflecting differences in porosity and diffusion pathways. These structural differences also affected skin delivery, with 3D-printed systems demonstrating higher epidermal flux than the other formulations. Conclusions: Overall, fabrication method governed film microstructure and thereby controlled menthol entrapment, release, and transdermal performance. Extrusion-based 3D printing offers a promising strategy for designing transdermal systems for volatile compounds with improved structural control and delivery efficiency. Full article
Show Figures

Figure 1

Back to TopTop