Therapeutic Advances in Chronic Diseases: Innovation and Drug Repurposing

Dear Colleagues,

Chronic diseases such as cancer, neurodegenerative disorders, cardiovascular conditions, and chronic inflammatory syndromes represent a growing global health challenge, demanding the continuous refinement of therapeutic approaches. Recent advances in pharmaceutical sciences have opened up new avenues to address these conditions more effectively, not only through the development of innovative therapeutic compounds and delivery technologies but also by rethinking and expanding the applications of established compounds. Reformulation, targeted delivery, and strategic combination therapies are increasingly recognized for their potential to enhance efficacy, reduce toxicity, and improve patient adherence. This evolving landscape underscores the importance of integrating pharmacological innovation with translational insights to optimize treatment outcomes for chronic illnesses.

This Special Issue aims to highlight therapeutic innovations in the management of chronic diseases, focusing both on (i) the development of novel therapeutic agents and formulations and (ii) the strategic repurposing, reformulation, or combination of existing compounds to optimize clinical outcomes. Particular emphasis will be placed on approaches that improve drug bioavailability, target selectivity, and reductions in adverse effects, including drug delivery systems and combination therapies. Submissions exploring translational research, therapeutic target discovery, preclinical evaluations, and drug delivery strategies tailored to chronic pathologies are especially welcome. We invite the submission of original research and review articles that contribute to advancing our understanding and application of therapeutic compounds, whether novel or repurposed, for chronic disease treatment. Insights into mechanistic actions, pharmacokinetics, and formulation science will be key to this discussion.

Dr. Bruna Fernandes Pinto
Dr. Vladimir Dobričić
Dr. Bárbara Pinto
Guest Editors

Manuscript Submission Information

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