Microbiome, Immunity, and Cancer: Deciphering the Intricate Crosstalk and Regulatory Networks
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".
Deadline for manuscript submissions: 5 June 2026 | Viewed by 54
Special Issue Editor
Interests: microbiome; immunology; gastrointestinal cancers; nutrition; gut–brain axis; neurodegeneration; neuroinflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The dynamic interplay among the host microbiome, immune system, and cancer represents a critical and rapidly evolving frontier in oncology. This Special Issue of Nutrients invites original research and comprehensive review articles aimed at elucidating how microbial communities influence carcinogenesis, tumor progression, and, importantly, the efficacy and toxicity of anti-cancer therapies. In addition to the traditional focus on the gut microbiome, this Special Issue places particular emphasis on the emerging role of the intratumoral microbiome and its direct regulatory functions within the tumor microenvironment.
We particularly welcome studies that characterize the gut and intratumoral microbiome, as well as the associated immune responses, to shed light on the complex regulatory networks that govern this crosstalk. Submissions exploring the bidirectional interactions between microbiota and the immune system in cancer initiation, progression, and therapeutic response are of special interest. Moreover, we welcome contributions that propose innovative strategies to modulate the microbiota–immunity–cancer axis for therapeutic purposes. We especially encourage manuscripts that investigate how dietary patterns, specific nutrients, and bioactive compounds shape the microbiome–immune system axis and, consequently, modulate cancer risk and treatment outcomes. Understanding how nutritional interventions can restore microbial balance and immune homeostasis offers promising avenues for innovative, personalized, and preventive oncology strategies.
Through this collection, we aim to advance the understanding of the microbiota–immunity–cancer triad and inspire novel translational approaches for cancer prevention and treatment.
Dr. Elena Niccolai
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- microbiome
- immunity
- cancer
- immunotherapy
- metabolites
- nutrition
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