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Nutrients
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Recent Advances in the Regulation of Lipid Metabolism by Food...
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Recent Advances in the Regulation of Lipid Metabolism by Food Bioactive Ingredients

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: 10 August 2025 | Viewed by 1006

Special Issue Editor

Dr. Chong Zhao

E-Mail Website
Guest Editor
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Interests: bioactive compounds; autophagy; ferroptosis; fatty acids; NAFLD; skin health; anti-fatigue; lipid metabolism; cell signal tranduction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dysregulated lipid metabolism plays a crucial role in various diseases, including diabetes, MASLD, cancer, and cardiovascular diseases. Natural products (e.g., alkaloids, polyphenols, and terpenoids) and nutrients (e.g., vitamins and functional lipids) hold significant potential for preventing lipid metabolism-associated chronic diseases. However, the underlying mechanisms remain largely unknown. The aim of this Special Issue is to provide a broader perspective of the latest advances in the targets and structure–activity relationships of those bioactive components in lipid metabolism. Moreover, we are particularly interested in lipid peroxidation-executed ferroptosis, which has emerged as a potentially effective target for various chronic diseases. Therefore, in this Special Issue, we call for submissions from potential topics including, but not limited to, the following: the role of natural products, nutrients, and their combinations in lipid absorption, synthesis, lipid droplet formation and catabolism, lipid composition of the cell membrane, lipid peroxidation, and ferroptosis.

We welcome both comprehensive review articles and original research on any of the proposed topics.

You may choose our Joint Special Issue in Foods.

Dr. Chong Zhao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipid metabolism
  • natural products
  • nutrients
  • functional lipids
  • chronic diseases
  • MASLD
  • ferroptosis
  • food bioactive ingredients

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Published Papers (2 papers)

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Research

20 pages, 1641 KiB  
Article
The Protective Effects of Pectic Polysaccharides on Dextran Sulfate Sodium-Induced Colitis in Drosophila melanogaster and Their Structure–Function Relationships
by Zhenou Sun, Tianyu Qi, Boyu Cheng, Yingxiao Guo, Dima Atehli, Steve W. Cui, Ji Kang and Qingbin Guo
Nutrients 2025, 17(10), 1738; https://doi.org/10.3390/nu17101738 - 20 May 2025
Abstract
Background: Pectic polysaccharides exhibit therapeutic potential against intestinal inflammation. However, the influence of structural variations on their efficacy remains largely unexplored. Methods: This study investigated the structural and anti-inflammatory relationships of okra pectin (OP), citrus pectin (CP), apple pectin (AP), and hawthorn pectin [...] Read more.
Background: Pectic polysaccharides exhibit therapeutic potential against intestinal inflammation. However, the influence of structural variations on their efficacy remains largely unexplored. Methods: This study investigated the structural and anti-inflammatory relationships of okra pectin (OP), citrus pectin (CP), apple pectin (AP), and hawthorn pectin (HP). Based on FT-IR spectra, CP was identified as a high-methoxyl pectin, with a degree of methyl esterification (DM) of 72.07 ± 3.86%. OP, AP, and HP were low-methoxyl pectins with the following DM values: 19.34 ± 3.04%, 32.11 ± 1.71%, and 38.67 ± 2.75%, respectively. Results: Monosaccharide composition analysis revealed that OP exhibited the highest abundance of RG-I regions among all the samples. Homogalacturonan (HG) was the predominant structural region in AP and HP, while CP contained both of the aforementioned structural regions. Our findings demonstrated that OP and CP significantly ameliorated dextran sulfate sodium (DSS)-induced colitis in the wild-type Drosophila melanogaster strain w1118, as evidenced by improved intestinal morphology, reinforced intestinal barrier function, and enhanced locomotor and metabolic activity. These effects were mediated by the inhibition of JAK/STAT signaling and the activation of the Nrf2/Keap1 pathway. Notably, reducing the molecular weight of CP to 18.18 kDa significantly enhanced its therapeutic efficacy, whereas a reduction in OP molecular weight to 119.12 kDa extended its median lifespan. Conclusions: These findings first suggest that abundant RG-I structures and low molecular weight endowed pectins with significant anti-inflammatory activity. Full article
(This article belongs to the Special Issue Recent Advances in the Regulation of Lipid Metabolism by Food Bioactive Ingredients)
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14 pages, 3368 KiB  
Article
Medium-Chain Fatty Acids Selectively Sensitize Cancer Cells to Ferroptosis by Inducing CD36 and ACSL4
by Kai Han, Jiaxuan Li, Shutao Yin, Hongbo Hu and Chong Zhao
Nutrients 2025, 17(5), 794; https://doi.org/10.3390/nu17050794 - 25 Feb 2025
Viewed by 823
Abstract
Background: Inducing ferroptosis in cancer cells is a promising therapeutic strategy. It has been shown that certain types of fatty acids can induce ferroptosis in multiple types of cancer cells. Methods: Here, we employed crystal violet staining and CCK8 to assess cell viability, [...] Read more.
Background: Inducing ferroptosis in cancer cells is a promising therapeutic strategy. It has been shown that certain types of fatty acids can induce ferroptosis in multiple types of cancer cells. Methods: Here, we employed crystal violet staining and CCK8 to assess cell viability, a Liperfluo probe and commercial kit to measure lipid peroxides, and western blotting and RNA interference to detect protein levels. Results: This study demonstrates for the first time that the medium-chain fatty acids lauric acid (LA-m), octanoic acid (OA-m), and decanoic acid (DA-m) selectively sensitize various cancer cell types to ferroptosis induced by either RSL3, a well-known inducer of ferroptosis, or linoleic acid (LA-l), a ω-6 polyunsaturated fatty acid (PUFA). Mechanistically, the ferroptosis-sensitizing effect of medium-chain fatty acids is associated with their ability to upregulate cluster of differentiation 36 (CD36) and acyl-CoA synthetase long-chain family member 4 (ACSL4) expression. Conclusions: These findings suggest that medium-chain fatty acids could be developed as novel ferroptosis sensitizers to enhance ferroptosis-based cancer therapy. Full article
(This article belongs to the Special Issue Recent Advances in the Regulation of Lipid Metabolism by Food Bioactive Ingredients)
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