Nutraceuticals for Treatment of Inflammatory Bowel Disease (IBD)
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".
Deadline for manuscript submissions: closed (5 April 2024) | Viewed by 4055
Special Issue Editors
2. Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy
Interests: inflammatory bowel disease; andrology; infertility; cytokines; the gut microbiota; epidemiology; nutraceutical polyphenols; micronutrients
Special Issues, Collections and Topics in MDPI journals
Interests: gut microbiota; virology; epidemiology; nutraceutical polyphenols; micronutrients
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. Over the past 10 years, many studies amply demonstrate that nutraceuticals could be used in the prevention and treatment of IBD and sought better alternative or supplementary treatment methods for IBD patients. Furthermore, nutraceuticals regulate intestinal immune homeostasis and improve intestinal barrier function. For example, the therapeutic effects of polyphenols in IBD include a reduction in local oxidative stress, the regulation of NF-kB and mitogen-activated protein kinase (MAPK) signaling pathways, and the downregulated secretion of inflammatory factors such as TNF- α and IL-8. Furthermore, the therapeutic effect of resveratrol on IBD was attributed to reducing oxidative stress, inhibiting the activation of NF-kB, and reducing proinflammatory cytokines and prostaglandins. In addition, polyphenols can regulate the structure and function of intestinal flora, improve the stability of tight junctions, and strengthen intestinal barrier function. Other studies have shown that polyphenols can increase the abundance of Lactobacillus and Bifidobacterium in the intestinal tract, and a large dose of polyphenols can reduce pathogenic microorganisms. Therefore, it is favourable to verify the usefulness of nutraceuticals in order to promote the intestinal microbiota as the first line of prevention and ensure a fair balance between the populations of microorganisms that inhabit the human gastrointestinal tract.
Prof. Dr. Roberto Castiglione
Dr. Paola Checconi
Guest Editors
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Keywords
- inflammatory bowel disease
- nutraceutical polyphenols
- gut microbiota
- oxidative stress
- inflammatory cytokines
- infections and chronic inflammatory bowel disease
- reproductive health
- infertility
- prostate diseases
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