nutrients-logo

Journal Browser

Journal Browser

Nutritional Approaches to Cancer Prevention and Therapeutic Support

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 5 May 2026 | Viewed by 532

Special Issue Editors


E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, CS, Italy
Interests: Mediterranean diet; natural compounds; omega-3 polyunsaturated fatty acid; PPAR gamma; breast cancer; endocrine-related cancers; prevention of metabolic and chronic degenerative diseases

E-Mail Website
Guest Editor
1. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Cosenza, Italy
2. Centro Sanitario, University of Calabria, 87036 Cosenza, Italy
Interests: Mediterranean diet; iodine deficiency; natural compounds; prevention of metabolic and chronic degenerative diseases; omega-3 polyunsaturated fatty acid; PPAR gamma; breast cancer; endocrine-related cancers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dietary supplements include macronutrients, vitamins, and minerals and varied non-essential nutrients which are important for human health. The role of nutritional supplements in preventing and treating cancer is under investigation. However, only a few human clinical studies have confirmed their safety and benefits, and their use during cancer treatment remains still controversial. Although nutritional supplements can have a positive impact on individuals with cancer, further research is needed to draw conclusions and allow the use of the nutritional supplement in clinical practice. This Special Issue will examine the usefulness of dietary supplements for treating cancer diseases and their complications. All these topics related to “Cancer Prevention and Treatment” and “Nutritional Supplements” are potential objectives of our Special Issue, in which we cordially invite clinicians and researchers to submit either original (preclinical and human studies) or review articles.

Dr. Giuseppina Augimeri
Prof. Dr. Daniela Bonofiglio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional supplements
  • nutraceuticals
  • bioactive compounds
  • phytochemicals
  • dietary supplements
  • macronutrients
  • micronutrients
  • Mediterranean diet
  • healthy diet
  • healthy lifestyle
  • cancer prevention
  • cancer treatment
  • onconutraceuticals

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 864 KB  
Article
Association Between Nutritional Status and Extranodal Extension of Lymph Node Metastases in Head and Neck Squamous Cell Cancers
by Kornél Dános, Mátyás Majoros, Lili Tóth, Benedek Besenczi, Mohammad Aouf, Angéla Horváth, László Tamás and Imre Uri
Nutrients 2026, 18(4), 706; https://doi.org/10.3390/nu18040706 - 22 Feb 2026
Viewed by 46
Abstract
Introduction: Extranodal extension (ENE) is a well-established adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC), associated with reduced survival and the need for intensified therapy. Nutritional status—commonly assessed using the Prognostic Nutritional Index (PNI) and Body Mass Index (BMI)—also influences [...] Read more.
Introduction: Extranodal extension (ENE) is a well-established adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC), associated with reduced survival and the need for intensified therapy. Nutritional status—commonly assessed using the Prognostic Nutritional Index (PNI) and Body Mass Index (BMI)—also influences outcomes in HNSCC. However, whether or not ENE correlates with nutritional status has not been previously investigated. Methods: We conducted a retrospective cohort study of 109 treatment-naïve HNSCC patients with pathologically confirmed nodal metastases who underwent primary tumor resection and neck dissection between 2014 and 2025 at a national tertiary center. ENE status was determined histologically. Nutritional status was evaluated using BMI, PNI, serum albumin, and percentage of weight loss at diagnosis. Statistical analyses included t-tests, Chi-square tests, ANOVA, Cox regression, Kaplan–Meier survival analysis, and Full Factorial General Linear Models. Results: ENE was present in 54.1% of patients and significantly reduced overall survival (Kaplan–Meier p = 0.006; Cox regression RR = 1.927, p = 0.008). No significant differences in BMI, PNI, weight loss, or serum albumin were observed between ENE-positive and ENE-negative groups. ENE prevalence varied significantly by tumor origin (p = 0.018), being highest in hypopharyngeal cancers (75.8%) and lowest in oral cavity tumors (25.0%). ENE status was independent of tobacco use, alcohol abuse, and all nutritional markers across TNM 8/9 subgroups. Conclusions: ENE is a strong prognostic marker in HNSCC, appearing to be independent of nutritional status. The demonstrated heterogeneity of ENE prevalence among tumor subsites supports the need for individualized management approaches. Full article
(This article belongs to the Special Issue Nutritional Approaches to Cancer Prevention and Therapeutic Support)
Show Figures

Figure 1

Back to TopTop