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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metal–Organic Frameworks in Biological Systems: Synthesis, Bioactivity, and Biomedical Applications submission deadline 28 Feb 2027 | Viewed by 67 | Submission Open
Keywords: metal–organic frameworks (MOFs); biological and biomedical application; drug delivery; antimicrobial; anticancer; structure–activity relationships
(This special issue belongs to the Section Organometallic Chemistry)
Safety Control and Quality Analysis in Food Processing submission deadline 28 Feb 2027 | Viewed by 64 | Submission Open
Keywords: food safety; food quality; NIR spectroscopy; FT-NIR; chemometrics; food adulteration; non-destructive analysis; food processing; authentication; multivariate analysis
(This special issue belongs to the Section Food Chemistry)
Research and Application of Liquid Chromatography for the Separation and Quantification of Bioactive Compounds
edited by
submission deadline 28 Feb 2027 | Viewed by 61 | Submission Open
Keywords: liquid chromatography; method validation; bioactive compounds; sample preparation; separation; determination
(This special issue belongs to the Section Analytical Chemistry)
Bioactive Compounds from Medicinal and Aromatic Plants: Chemistry, Mechanisms, and Applications submission deadline 28 Feb 2027 | Viewed by 53 | Submission Open
Keywords: natural products chemistry; medicinal plants; aromatic plants; plant secondary metabolites; bioactive compounds; phytochemistry; compound isolation; biological activity; mechanism of action; green extraction techniques; drug discovery; semi-synthesis; natural product-based therapeutics; cosmeceuticals; functional foods
(This special issue belongs to the Section Natural Products Chemistry)
Non-Conventional Processing Technologies for Molecular Modification of Food Biomolecules: Structure–Function Relationships submission deadline 28 Feb 2027 | Viewed by 48 | Submission Open
Keywords: non-conventional technologies; food biomolecules; molecular modification; structure-function relationships; ultrasound; high-pressure processing; cold plasma; pulsed electric fields
(This special issue belongs to the Section Food Chemistry)
Carbohydrate-Active Enzymes and Carbohydrate Engineering: From Mechanisms to Applications
edited by , Birte Svensson and
submission deadline 28 Feb 2027 | Viewed by 39 | Submission Open
Keywords: carbohydrate-active enzymes; enzyme discovery; enzyme mechanism; enzyme engineering; carbohydrate modification; structural analysis of carbohydrates; biomass conversion; enzymes applied in food, biotech and pharma industries
(This special issue belongs to the Section Chemical Biology)
Theoretical and Computational Approaches to Natural Products and Their Derivatives
edited by
submission deadline 28 Feb 2027 | Viewed by 31 | Submission Open
Keywords: natural products; natural product derivatives; quantum-chemical calculations; chemical reactivity descriptors; thermodynamic properties; spectroscopic characteristics; structure-activity relationship; molecular docking; molecular dynamics simulations; pharmacophore modeling; network pharmacology; artificial intelligence; molecular modeling; pharmaceuticals; agrochemicals; nutraceuticals; cosmetics
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Advanced Technologies for Water Pollution Control, 2nd Edition
edited by and
submission deadline 1 Mar 2027 | Viewed by 99 | Submission Open
Keywords: water pollution; advanced oxidation processes; membrane technologies; nanotechnology application; wastewater remediation; advanced technologies
(This special issue belongs to the Section Green Chemistry)
Innovative Chemical Pathways for CO2 Conversion, 2nd Edition
edited by and Juqin Zeng
submission deadline 1 Mar 2027 | Viewed by 76 | Submission Open
Keywords: CO2 conversion; CO2 utilization; carbon capture and utilization (CCU); CO2 reduction; carbon dioxide valorization; catalytic CO2 conversion; electrochemical CO2 reduction; photocatalytic CO2 conversion; thermocatalytic CO2 conversion; green chemistry; sustainable chemistry; carbon recycling; carbon neutrality; circular carbon economy; renewable energy; sustainable chemical processes; carbon-based fuels; value-added chemicals; climate change mitigation; CO2 emissions reduction; decarbonization; energy transition; life cycle assessment; process intensification
(This special issue belongs to the Section Green Chemistry)
Advanced Photo/Electrocatalysts for Energy Conversion and Environmental Applications, 3rd Edition
edited by and Dengrong Sun
submission deadline 10 Mar 2027 | 4 articles | Viewed by 3108 | Submission Open
Keywords: photocatalyst; electrocatalysis; nanostructured materials; surface/interface regulation; environment; energy
(This special issue belongs to the Section Photochemistry)
Advances in Physical Chemistry: From Theory to Applications
edited by
submission deadline 15 Mar 2027 | 1 articles | Viewed by 542 | Submission Open
Keywords: electronic-structure theory; ultrafast spectroscopy; AI-driven modelling; energy-carrier dynamics; machine learning; medical physical chemistry; commercialization of physical chemistry
(This special issue belongs to the Section Physical Chemistry)
Emerging Trends in the Design and Functionality of Organic Dyes and Pigments
edited by Alina Raditoiu and
submission deadline 15 Mar 2027 | Viewed by 325 | Submission Open
Keywords: molecular design; functional colorants; sustainable dyes; natural colorants; eco-friendly pigments; photophysical properties; charge transfer mechanisms; textile functionalization; bio-based dyes; synthetic strategies; optical properties; photostability; dye-sensitized applications
(This special issue belongs to the Section Colorants)
The Design and Synthesis of Nanomaterials for Electrochemical Energy Storage and Conversion
edited by Yan Zhou and Zhen Wu
submission deadline 16 Mar 2027 | 1 articles | Viewed by 1428 | Submission Open
Keywords: electrochemical energy storage; electrochemical energy conversion; batteries; supercapacitors; nanostructured electrode materials; nanostructured electrocatalysts
(This special issue belongs to the Section Applied Chemistry)
Characterization and Instrumental Analysis of Aroma-Active Compounds in Fermented Food and Beverage, the Third Edition
edited by
submission deadline 25 Mar 2027 | 1 articles | Viewed by 794 | Submission Open
Keywords: fermentation; fermented food production; fermented food flavor; aroma characterization; gas chromatography–mass spectrometry/olfactory (GC-MS/O); sensorial properties; HS-SPME; stir bar and thin-film sorptive extraction
(This special issue belongs to the Section Flavours and Fragrances)
Advanced Biofuel Production submission deadline 30 Mar 2027 | 1 articles | Viewed by 731 | Submission Open
Keywords: biofuels; biomass conversion; catalysis; pyrolysis; synthetic fuels; waste to energy; renewable diesel; sustainable aviation fuel; hydrothermal liquefaction
(This special issue belongs to the Section Applied Chemistry)
Advances in Nanomaterials for Biomedical Applications, 2nd Edition
edited by Xueen Jia and Ce Zhang
submission deadline 31 Mar 2027 | 3 articles | Viewed by 9593 | Submission Open
Keywords: 2D nanomaterials; metal–organic frameworks (MOFs); metasurfaces; biosensor; drug delivery
(This special issue belongs to the Section Nanochemistry)
Unveiling the Applications of Bioactive Compounds in Functional Foods for Optimal Human Health—2nd Edition
edited by and
submission deadline 31 Mar 2027 | 4 articles | Viewed by 6939 | Submission Open
Keywords: functional foods; bioactive ingredients; health benefits; immune function; gut health; disease prevention
(This special issue belongs to the Section Food Chemistry)
Wine Chemistry: From Flavor Profiling to Sensory Quality submission deadline 31 Mar 2027 | 3 articles | Viewed by 6852 | Submission Open
Keywords: wine; volatile organic compounds (VOCs); flavor; aroma; phenolic compounds; chemical composition; sensory; fermentation process
(This special issue belongs to the Section Flavours and Fragrances)
Nutritional Properties, Sensory Profile and Bioactive Components of Food, 3rd Edition submission deadline 31 Mar 2027 | 5 articles | Viewed by 6708 | Submission Open
Keywords: food analysis; bioactive compounds; sensory characteristics; food composition; functional food ingredients
(This special issue belongs to the Section Food Chemistry)
Nanomaterials for Biomedicine: Innovations and Challenges
edited by and
submission deadline 31 Mar 2027 | 4 articles | Viewed by 6290 | Submission Open
Keywords: nanomaterial; targeted drug delivery; bio-imaging; antimicrobial application; cancer immunotherapy; nanovaccine
(This special issue belongs to the Section Nanochemistry)
Food Sustainability: Promising By-Products for Valorization—3rd Edition
edited by , Mihai Babotă and
submission deadline 31 Mar 2027 | 6 articles | Viewed by 6223 | Submission Open
Keywords: agri-food by-products; extraction and separation methods; functional bio-based ingredients; analytical chemistry; plant toxins; secondary metabolites; side-stream processing; biorefinery approaches
(This special issue belongs to the Section Food Chemistry)
Ionic Liquids and Molecular Materials: Advances in Functional Interfaces and Applications submission deadline 31 Mar 2027 | 5 articles | Viewed by 6034 | Submission Open
Keywords: ionic fluids; bulk properties; surface and interfacial properties; thin films; vacuum engineering; energy harvesting and storage; functional materials
(This special issue belongs to the Section Physical Chemistry)
Heterocycles: Design, Synthesis and Biological Evaluation, 4th Edition submission deadline 31 Mar 2027 | 3 articles | Viewed by 5852 | Submission Open
Keywords: heterocycles; organic synthesis; drug design; biological activity; medicinal chemistry
(This special issue belongs to the Section Medicinal Chemistry)
Chemistry Applied to Enhanced Oil Recovery
edited by and Mingwei Gao
submission deadline 31 Mar 2027 | 4 articles | Viewed by 4407 | Submission Open
Keywords: advanced chemical materials for EOR; oil–gas field chemical working fluids; molecular engineering of EOR materials; reservoir chemical compatibility; chemical flooding enhancement mechanisms
(This special issue belongs to the Section Applied Chemistry)
Development of Computational Approaches in Chemical Biology
edited by , Dianyong Tang and Yichang Liu
submission deadline 31 Mar 2027 | 3 articles | Viewed by 4335 | Submission Open
Keywords: computational chemical biology; molecular modeling; molecular dynamics simulations; AI in drug discovery; protein–ligand interactions; protein design; biological networks; multi-omics integration
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Bioactive Components From Fungi in the Context of Biomedical Applications
edited by Magdalena Jaszek
submission deadline 31 Mar 2027 | 2 articles | Viewed by 4280 | Submission Open
Keywords: fungal bioactive substances; polysaccharides; phenolic compounds; mushroom extracts; medicinal mushrooms; biomedical applications; functional food
(This special issue belongs to the Section Natural Products Chemistry)
The Chemistry of Food Quality Changes During Processing and Storage
edited by
submission deadline 31 Mar 2027 | 4 articles | Viewed by 4073 | Submission Open
Keywords: innovative processing; microbiological quality; mitigation strategies; processing optimization; shelf life extension; physicochemical changes; nutritional value; antioxidant capacity
(This special issue belongs to the Section Food Chemistry)
Degradation of Aromatic Compounds in the Environment submission deadline 31 Mar 2027 | 2 articles | Viewed by 3651 | Submission Open
Keywords: aromatic compounds; microorganisms; biodegradation; biotransformation; advanced oxidation processes
(This special issue belongs to the Section Organic Chemistry)
Plant Bioactives in Human Health: From Phytochemistry to Molecular Mechanisms submission deadline 31 Mar 2027 | 2 articles | Viewed by 3510 | Submission Open
Keywords: bioactive compounds; bioavailability; extraction methods; biological activities; cell signalling; functional applications; nutraceuticals; human metabolism; toxicity; bioactive-gut microbiota relationships
(This special issue belongs to the Section Natural Products Chemistry)
Design and Preparation of New Metal Catalysts for Functional Organic Compounds Synthesis
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 3098 | Submission Open
Keywords: transition metal complexes; hybrid catalysts; nanocatalysts; single-atom catalysts; sustainable organic synthesis; natural products
(This special issue belongs to the Section Organometallic Chemistry)
Phytochemicals as Promising Molecules in Acute and Chronic Neurodegeneration
edited by
submission deadline 31 Mar 2027 | 1 articles | Viewed by 3050 | Submission Open
Keywords: phytochemicals; nutrients; morphology; transmission electron microscopy; autophagy; proteasome; neurodegeneration; central nervous system; peripheral nervous system; sensory organs
(This special issue belongs to the Section Natural Products Chemistry)
Advances in Microplastics and Nanoplastics Analysis, 2nd Edition submission deadline 31 Mar 2027 | 4 articles | Viewed by 2988 | Submission Open
Keywords: microplastics; nanoplastics; monitoring; analytical methods; ecotoxicological assays
(This special issue belongs to the Section Analytical Chemistry)
Feature Papers in Food Chemistry—4th Edition
edited by
submission deadline 31 Mar 2027 | 7 articles | Viewed by 2962 | Submission Open
Keywords: food chemistry; functional food; ingredients; bioactivity; antioxidants; food safety and health; food processing
(This special issue belongs to the Section Food Chemistry)
Recent Advances in the Organic Synthesis of Bioactive Natural Compounds and Their Analogs submission deadline 31 Mar 2027 | 2 articles | Viewed by 2694 | Submission Open
Keywords: bioactive natural compounds; organic synthesis; natural products; synthetic methodologies; medicinal chemistry; drug discovery; total synthesis
(This special issue belongs to the Section Natural Products Chemistry)
Biological Activity of Metal Complexes: Design and Characterization Strategies submission deadline 31 Mar 2027 | 1 articles | Viewed by 2655 | Submission Open
Keywords: metal complexes; biological activity; metallodrugs; anticancer: antibacterial; antiviral; antiparasitic: delivery methods; biophysical characterization; DFT; docking
(This special issue belongs to the Section Inorganic Chemistry)
Rare Earth Luminescent Materials and Complexes: Structure, Properties and Applications
edited by , and Vladimira S. Videva
submission deadline 31 Mar 2027 | 1 articles | Viewed by 2570 | Submission Open
Keywords: rare earth elements; lanthanide complexes; luminescent materials; photophysical properties; upconversion; downshifting; coordination compounds; hybrid materials; optical materials; bioimaging; photonics; sensing; nanomaterials; structure–property relationships
(This special issue belongs to the Section Photochemistry)
Physicochemical Interactions and Modifications of Composition, Structure and Properties During Food Processing submission deadline 31 Mar 2027 | 4 articles | Viewed by 2527 | Submission Open
Keywords: phytochemicals; bioactive compounds; functional food; food processing
(This special issue belongs to the Section Food Chemistry)
Advances in Sustainable and Functional Bio-Based Porous Materials for Environmental Remediation
edited by and Yufei Nan
submission deadline 31 Mar 2027 | 2 articles | Viewed by 2241 | Submission Open
Keywords: bio-based materials; porous structure; adsorption of heavy metals/organics/dyes/microplastics; sustainable processing
(This special issue belongs to the Section Materials Chemistry)
Modern Application of Cycloaddition Reactions: Experimental and Theoretical Research
edited by and Patricia Perez
submission deadline 31 Mar 2027 | 1 articles | Viewed by 2097 | Submission Open
Keywords: cycloaddition reactions; molecular electron density theory; density functional theory; reaction mechanism; organic synthesis; bioactive compounds; biological activity of heterocyclic compounds
(This special issue belongs to the Section Organic Chemistry)
Advances in the Mass Spectrometry of Chemical and Biological Samples, 2nd Edition
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 1993 | Submission Open
Keywords: sample preparation, extraction, and ionization techniques; targeted and untargeted MS-based methods; high-resolution mass spectrometry (HRMS); MS-based omics; MS imaging; MS-based biomarker discovery and clinical diagnosis; MS-based drug development and toxicity monitoring; MS-based analysis of microbiome; MS in food chemistry and control; MS in forensic science; MS in cosmetic science; MS in environmental science; miniature MS systems; MS applications in nanomaterials development; MS applications in synthetic chemistry
(This special issue belongs to the Section Analytical Chemistry)
Functional Nanomaterials and Composites: From Design Towards Energy & Environmental Applications submission deadline 31 Mar 2027 | 3 articles | Viewed by 1967 | Submission Open
Keywords: nanomaterials; composites; energy applications; environmental remediation; sustainable technologies
(This special issue belongs to the Section Nanochemistry)
Chemical and Physical Interactions Between Food and Packaging: Safety, Stability, and Quality submission deadline 31 Mar 2027 | 2 articles | Viewed by 1922 | Submission Open
Keywords: packaging; coating; physical properites; chemical properties; food quality; food safety
(This special issue belongs to the Section Food Chemistry)
Extraction and Analysis of Natural Products in Food—4th Edition submission deadline 31 Mar 2027 | 3 articles | Viewed by 1848 | Submission Open
Keywords: natural products; extraction methodologies: green impacts and sustainability; separation and purification techniques; agri-food byproducts; natural bioactive compounds; food ingredients; industrial application
(This special issue belongs to the Section Natural Products Chemistry)
Synthesis, Characterization, and Biological Evaluation of Small Molecules as Anticancer Agents
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 1831 | Submission Open
Keywords: anticancer small molecules; medicinal chemistry; drug design and synthesis; structure–activity relationship; targeted therapy; apoptosis induction; preclinical evaluation
(This special issue belongs to the Section Bioorganic Chemistry)
Recent Advances in Antibacterial Nanomaterials
edited by
submission deadline 31 Mar 2027 | 1 articles | Viewed by 1817 | Submission Open
Keywords: nanoparticles; biochemistry; antibacterial; bacteriostatic; cell membrane
(This special issue belongs to the Section Nanochemistry)
Metal Ions and Metal Complexes in Medicinal Chemistry submission deadline 31 Mar 2027 | 1 articles | Viewed by 1753 | Submission Open
Keywords: metal ions; metal complexes; synthesis; study; spectral analysis; biological activity; ligands
(This special issue belongs to the Section Medicinal Chemistry)
Bioactive Molecules for Targeted Cancer Therapy
edited by and Robert A. Falconer
submission deadline 31 Mar 2027 | 1 articles | Viewed by 1647 | Submission Open
Keywords: enzymatic inhibitors; fragment-based discovery; chemical biology; covalent ligands; payloads; prodrug; (poly)peptide conjugates; antibody–drug conjugates; computational chemistry
(This special issue belongs to the Section Medicinal Chemistry)
Chemistry, Bioactivity and Authenticity of Sugar-Rich and Fermented Foods and Beverages submission deadline 31 Mar 2027 | 3 articles | Viewed by 1608 | Submission Open
Keywords: sugar-rich foods; fermented beverages; chemical characterization; analytical techniques; bioactive compounds; metabolomics; authenticity; food control
(This special issue belongs to the Section Food Chemistry)
Advances in Phytochemical Analysis of Plant-Derived Bioactive Natural Products
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 1565 | Submission Open
Keywords: phytochemical analysis; plant-derived bioactive compounds; natural products chemistry; polyphenols; metabolite profiling; sustainable plant matrices; circular economy valorization; agro-industrial by-products; nutraceutical applications; structure–activity relationships
(This special issue belongs to the Section Natural Products Chemistry)
Biomass-Derived Materials: From Molecular Design to Sustainable Applications submission deadline 31 Mar 2027 | 2 articles | Viewed by 1555 | Submission Open
Keywords: biomass-derived materials; renewable feedstocks; molecular design; green synthesis; sustainable materials; biopolymers; biochars and activated carbons; functional composites; circular economy
(This special issue belongs to the Section Green Chemistry)
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