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Nanomaterials for Biomedicine: Innovations and Challenges

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 606

Special Issue Editors


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Guest Editor Assistant
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China
Interests: polymer design and synthesis; fluorescence probe synthesis and imaging; nanomedicine; drug and gene delivery; tumor immunotherapy

Special Issue Information

Dear Colleagues,

Nanomaterials are profoundly transforming the field of biomedicine, emerging as crucial tools in addressing a wide range of health-related challenges. Their unique advantage lies in precisely tailoring their physical, chemical, and biological properties, enabling the development of advanced medical solutions. By modifying structural parameters, such as shape and size, researchers induce significant alterations in the materials' chemical behaviors and structural stability, facilitating precise customization to enhance their functionality in specific biological contexts. In recent years, we have seen an increasing amount of interest in exploring how these engineered physicochemical properties influence the performance and effectiveness of nanomaterials in biomedical applications.

This Special Issue aims to provide a comprehensive overview of the latest advancements in synthesizing and applying nanomaterials in biomedicine. We welcome original research articles and review papers investigating innovative synthesis methodologies, cutting-edge functionalization strategies, and the practical applications of nanomaterials across diverse areas. Topics of interest include but are not limited to, targeted drug delivery systems, bioimaging techniques, cancer immunotherapy strategies, nanovaccine innovations, and antimicrobial applications.

By compiling a wide range of contributions, we aim to highlight the transformative potential of nanotechnology in healthcare, paving the way for novel solutions that may redefine patient care and outcomes.

Prof. Dr. Jianxun Ding
Guest Editor

Dr. Guanqing Yang
Guest Editor Assistant

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterial
  • targeted drug delivery
  • bio-imaging
  • antimicrobial application
  • cancer immunotherapy
  • nanovaccine

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Published Papers (1 paper)

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Research

21 pages, 7450 KiB  
Article
Degradation of Folic Acid in the Composition of a Conjugate with Polyvinylpyrrolidone and Fullerene C60 Under UV and E-Beam Irradiation
by Alina A. Borisenkova, Dmitriy V. Baykov, Anna V. Titova, Vadim V. Bakhmetyev, Maria A. Markova, Zhanna B. Lyutova, Anton V. Popugaev, Vladislav S. Khaleev and Victor P. Sedov
Molecules 2025, 30(13), 2718; https://doi.org/10.3390/molecules30132718 - 24 Jun 2025
Viewed by 392
Abstract
Folic acid (FA) is used as a targeting ligand for targeted drug delivery to tumor cells, some types of which overexpress folate receptors on their surface. However, while the preparation of conjugates containing FA may comprise a multi-step process, FA presents low photostability [...] Read more.
Folic acid (FA) is used as a targeting ligand for targeted drug delivery to tumor cells, some types of which overexpress folate receptors on their surface. However, while the preparation of conjugates containing FA may comprise a multi-step process, FA presents low photostability under UV irradiation. In addition, FA undergoes radiolysis under the action of ionizing radiation, which is utilized for drug sterilization. In this study, we investigate the stability of FA in a conjugate (FA-PVP-C60) with fullerene C60 and polyvinylpyrrolidone under the action of UV (205–400 nm) and electron irradiation (doses from 2 to 8 kGy) at different pH (4.5, 7.2, 10.7). The degradation of FA is studied using fluorescence and UV–Vis spectroscopy. It is found that the fullerene C60 in the FA-PVP-C60 conjugate suppresses the degradation of FA during both photolysis and radiolysis, which is confirmed by the decrease in the quantum yield of fluorescence and the radiation chemical yield of FA destruction accompanied by increasing fullerene content in the conjugate (from 2.8 to 10 wt.%). Full article
(This article belongs to the Special Issue Nanomaterials for Biomedicine: Innovations and Challenges)
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