Triterpenes and Triterpenoids

Dear Colleagues,

Triterpenes, constituting one of the classes of higher terpenes, show a widespread occurrence in nature and can be found in almost all terrestrial and marine organisms. Nevertheless, most of the bioactive triterpenes have been detected in higher plants.

Triterpenes are naturally occurring alkenes included in the broad and structurally diverse group of triterpenoids, which also include natural degradation products, oxidation, and hydrogenation products. Taking into consideration the architecture of the carbon skeleton, triterpenes may be divided into linear and cyclic ones, mainly including tetracyclic and pentacyclic carbocycles.

Due to their relatively complex and diverse structures, triterpenoids frequently exhibit a wide range of biological activities, such as cytotoxic, anti-cancer, anti-inflammatory, anti-oxidative, anti-bacterial, anti-fungal, and would healing activity.

The continuous investigations of natural sources and biotransformation studies on known metabolites are constantly revealing new triterpenoids that might display even more promising properties. Taking together the current knowledge, triterpenes are considered a promising class of molecules for the development of new drugs.

Prof. Dr. Vassilios Roussis
Dr. Efstathia Ioannou
Guest Editor

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