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Open AccessReview

Review of Ginseng Anti-Diabetic Studies

by Wei Chen 1,2,3, Prabhu Balan 2,3 and David G. Popovich 1,*
1
School of Food and Advanced Technology, Massey University, Palmerston North 4442, New Zealand
2
Riddet Institute, Massey University, Palmerston North 4442, New Zealand
3
Alpha-Massey Natural Nutraceutical Research Centre, Massey University, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(24), 4501; https://doi.org/10.3390/molecules24244501
Received: 19 September 2019 / Revised: 3 December 2019 / Accepted: 6 December 2019 / Published: 9 December 2019
(This article belongs to the Collection Triterpenes and Triterpenoids)
Ginseng is one of the most valuable and commonly used Chinese medicines not only in ancient China but also worldwide. Ginsenosides, also known as saponins or triterpenoids, are thought to be responsible for the beneficial effects of ginseng. In this review, we summarize recent publications on anti-diabetic studies of ginseng extracts and ginsenosides in cells, animals, and humans. It seems that the anti-diabetic effect of ginseng is positive for type 2 diabetic patients but has no significant impact on prediabetes or healthy adults. Regulation of insulin secretion, glucose uptake, anti-oxidative stress, and anti-inflammatory pathways may be the mechanisms involved with ginseng’s anti-diabetic effects. Taken together, this summary provides evidence for the anti-diabetes effects of ginseng extracts and ginsenosides as well as the underlying mechanisms of their impact on diabetes. View Full-Text
Keywords: ginseng; ginsenosides; anti-diabetes; insulin; blood glucose ginseng; ginsenosides; anti-diabetes; insulin; blood glucose
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Chen, W.; Balan, P.; Popovich, D.G. Review of Ginseng Anti-Diabetic Studies. Molecules 2019, 24, 4501.

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