Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity
AbstractBetulin derivatives are a widely studied group of compounds of natural origin due to their wide spectrum of biological activities. This paper describes new betulin derivatives, containing a phosphonate group. The allyl-vinyl isomerization and synthesis of acetylenic derivatives have been reported. Structural identification of products as E and Z isomers has been carried out using 1H-, 13C-, 31P-NMR, and crystallographic analysis. The crystal structure in the orthorhombic space group and analysis of crystal packing contacts for 29-diethoxyphosphoryl-28-cyclopropylpropynoyloxy-lup-20E(29)-en-3β-ol 8a are reported. All new compounds were tested in vitro for their antiproliferative activity against human T47D (breast cancer), SNB-19 (glioblastoma), and C32 (melanoma) cell lines. View Full-Text
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Chrobak, E.; Bębenek, E.; Kadela-Tomanek, M.; Latocha, M.; Jelsch, C.; Wenger, E.; Boryczka, S. Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity. Molecules 2016, 21, 1123.
Chrobak E, Bębenek E, Kadela-Tomanek M, Latocha M, Jelsch C, Wenger E, Boryczka S. Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity. Molecules. 2016; 21(9):1123.Chicago/Turabian Style
Chrobak, Elwira; Bębenek, Ewa; Kadela-Tomanek, Monika; Latocha, Małgorzata; Jelsch, Christian; Wenger, Emmanuel; Boryczka, Stanisław. 2016. "Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity." Molecules 21, no. 9: 1123.
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