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Volume 21
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10.3390/molecules21040459
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Article

Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus

by
Namki Cho
1,2,
Eun Hye Moon
1,
Hyun Woo Kim
1,
Jaewoo Hong
3,
John A. Beutler
2 and
Sang Hyun Sung
1,*
1
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea
2
Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
3
Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
*
Author to whom correspondence should be addressed.
Molecules 2016, 21(4), 459; https://doi.org/10.3390/molecules21040459
Submission received: 9 February 2016 / Revised: 21 March 2016 / Accepted: 30 March 2016 / Published: 7 April 2016
(This article belongs to the Collection Triterpenes and Triterpenoids)
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Abstract

It is well known that activated microglia produce nitric oxide (NO), which has an important role in the pathophysiology of several neurodegenerative diseases such as Alzheimer’s disease. In the course of searching for novel therapeutic agents from medicinal plants against neuroinflammatory diseases, the methanolic extract of Tetrapanax papyriferus was found to have significant NO inhibitory activity in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Nine oleanane-type triterpenes, including two new compounds, epipapyriogenin C-3-O-β-d-glucopyranoside (6) and 11-O-butylpapyrioside LIIc (9), were isolated from the leaves and stems of Tetrapanax papyriferus. The structures of these compounds were elucidated with 1D- and 2D-NMR and MS data. Among these Δ11,13 oleanane-type triterpenes, compound 3 showed significant NO inhibitory activity in BV-2 cells, reducing the LPS-induced expression of COX-2 and pro-inflammatory cytokines such as TNF-α and IL-6. Compounds 7 and 9 also showed NO inhibitory activities among the Δ12 oleanane-type triterpene saponins. These results show that oleanane-type triterpenes isolated from T. papyriferus could be a potential natural resource of NO inhibitors used in the treatment of neurodegenerative disorders.
Keywords: Tetrapanax papyriferus; triterpenes; BV2 microglial cells; NO; COX-2 Tetrapanax papyriferus; triterpenes; BV2 microglial cells; NO; COX-2

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MDPI and ACS Style

Cho, N.; Moon, E.H.; Kim, H.W.; Hong, J.; Beutler, J.A.; Sung, S.H. Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus. Molecules 2016, 21, 459. https://doi.org/10.3390/molecules21040459

AMA Style

Cho N, Moon EH, Kim HW, Hong J, Beutler JA, Sung SH. Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus. Molecules. 2016; 21(4):459. https://doi.org/10.3390/molecules21040459

Chicago/Turabian Style

Cho, Namki, Eun Hye Moon, Hyun Woo Kim, Jaewoo Hong, John A. Beutler, and Sang Hyun Sung. 2016. "Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus" Molecules 21, no. 4: 459. https://doi.org/10.3390/molecules21040459

APA Style

Cho, N., Moon, E. H., Kim, H. W., Hong, J., Beutler, J. A., & Sung, S. H. (2016). Inhibition of Nitric Oxide Production in BV2 Microglial Cells by Triterpenes from Tetrapanax papyriferus. Molecules, 21(4), 459. https://doi.org/10.3390/molecules21040459

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