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Article

A New Triterpenoid from Teucrium viscidum

by
Xincai Hao
1,†,
Jinwen Zhang
2,†,
Guangxin Xia
3,
Yongbo Xue
1,
Zengwei Luo
1,
Yanyan Si
1,
Guangmin Yao
1,* and
Yonghui Zhang
1,*
1
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3
Central Research Institute, Shanghai Pharmaceutical Holding Co. Ltd, 898 Halei Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2013, 18(1), 1262-1269; https://doi.org/10.3390/molecules18011262
Submission received: 3 December 2012 / Revised: 1 January 2013 / Accepted: 7 January 2013 / Published: 21 January 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids 2013)
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Abstract

A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1–4 were evaluated for their inhibitory activities against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1).
Keywords: Teucrium viscidum; triterpenoids; lignans; 11β-HSD1 Teucrium viscidum; triterpenoids; lignans; 11β-HSD1

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MDPI and ACS Style

Hao, X.; Zhang, J.; Xia, G.; Xue, Y.; Luo, Z.; Si, Y.; Yao, G.; Zhang, Y. A New Triterpenoid from Teucrium viscidum. Molecules 2013, 18, 1262-1269. https://doi.org/10.3390/molecules18011262

AMA Style

Hao X, Zhang J, Xia G, Xue Y, Luo Z, Si Y, Yao G, Zhang Y. A New Triterpenoid from Teucrium viscidum. Molecules. 2013; 18(1):1262-1269. https://doi.org/10.3390/molecules18011262

Chicago/Turabian Style

Hao, Xincai, Jinwen Zhang, Guangxin Xia, Yongbo Xue, Zengwei Luo, Yanyan Si, Guangmin Yao, and Yonghui Zhang. 2013. "A New Triterpenoid from Teucrium viscidum" Molecules 18, no. 1: 1262-1269. https://doi.org/10.3390/molecules18011262

APA Style

Hao, X., Zhang, J., Xia, G., Xue, Y., Luo, Z., Si, Y., Yao, G., & Zhang, Y. (2013). A New Triterpenoid from Teucrium viscidum. Molecules, 18(1), 1262-1269. https://doi.org/10.3390/molecules18011262

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