Next Article in Journal
The Synthesis of Some Perhydrobenzimidazolinium Salts and Their Application in Pd-Carbene Catalyzed Heck and Suzuki Reactions
Next Article in Special Issue
Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine
Previous Article in Journal
Application of Thermally Responsive Elastin-like Polypeptide Fused to a Lactoferrin-derived Peptide for Treatment of Pancreatic Cancer
Previous Article in Special Issue
Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines
 
 
Article

Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts

1
Carl Gustav Carus-Institute, Am Eichhof 30, D-75223 Niefern-Öschelbronn, Germany
2
Betulin-Institute, Blumenstrasse 24, D-64297 Darmstadt, Germany
*
Author to whom correspondence should be addressed.
Molecules 2009, 14(6), 2016-2031; https://doi.org/10.3390/molecules14062016
Received: 22 April 2009 / Revised: 26 May 2009 / Accepted: 3 June 2009 / Published: 4 June 2009
(This article belongs to the Special Issue Triterpenes and Triterpenoids 2013)
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of 50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations. View Full-Text
Keywords: lupane; oleanane; ursane; triterpene dry extract; active plant extracts; triterpene distribution lupane; oleanane; ursane; triterpene dry extract; active plant extracts; triterpene distribution
Show Figures

Graphical abstract

MDPI and ACS Style

Jäger, S.; Trojan, H.; Kopp, T.; Laszczyk, M.N.; Scheffler, A. Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts. Molecules 2009, 14, 2016-2031. https://doi.org/10.3390/molecules14062016

AMA Style

Jäger S, Trojan H, Kopp T, Laszczyk MN, Scheffler A. Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts. Molecules. 2009; 14(6):2016-2031. https://doi.org/10.3390/molecules14062016

Chicago/Turabian Style

Jäger, Sebastian, Holger Trojan, Thomas Kopp, Melanie N. Laszczyk, and Armin Scheffler. 2009. "Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts" Molecules 14, no. 6: 2016-2031. https://doi.org/10.3390/molecules14062016

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop