Nitrogen-Containing Heterocycles as Significant Molecular Scaffolds for Medicinal and Other Applications

Dear Colleagues,

Aza-heterocyclic compounds that contain at least one nitrogen atom, including monocyclic and fused bicyclic ring systems, represent the largest and most diverse family of organic compounds. These versatile structural motifs differing in the number of ring members and functionalization, as well as the number, nature, and relative position of heteroatoms constituting the rings, are present in several biologically active natural compounds and in a large number of marketed small molecule drugs. The binding ability via coordinative or hydrogen bonding interactions seems to be an important factor in the development of biological effects, whereas certain physicochemical and pharmacokinetic properties of the molecules, such as aqueous solubility, intestinal absorption, and stability against metabolic degradation may also be modulated by the incorporation of these scaffolds. Besides their medicinal importance, nitrogen-containing heterocycles also find applications as corrosion inhibitors, preservatives, surface modifiers, copolymers, dyes, antistatic agents, agrochemicals, etc.

The diversity of the structures involved, as well as their practical relevance, have motivated research aimed at the development of efficient, selective, and environmentally friendly synthetic strategies. The present Special Issue is dedicated to the preparation of aromatic and non-aromatic nitrogen-containing heterocycles possessing any biological action or suitable for other potential applications in material science and catalysis. Contributions (original research articles and reviews) are expected primarily on the state of the art of green chemistry approaches as sustainable alternatives to conventional methodologies.

Dr. Eva Frank
Dr. György Szöllösi
Guest Editors

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