Recent Advances in Indole Derivatives in Medicinal and Synthetic Organic Chemistry

Dear Colleagues,

Heterocyclic chemistry provides a valuable source of novel compounds that possess diverse biological activities, mainly due to their exceptional capability to imitate the structure of peptides and to connect reversibly to proteins. Nitrogenous heterocycles have a broad range of bioactivities and are exceedingly versatile. They are used as essential intermediates in drug design for the synthesis of active molecules. The indole moiety is the most broadly available nitrogen-containing heterocycle in nature. The interesting molecular architecture of indole makes it a suitable candidate for drug development. Indole is a planar bicyclic molecule with a benzene ring fused to a pyrrole ring. It is an essential part of the amino acid tryptophan, hormone melatonin, neurotransmitter serotonin, and plant hormone heteroauxin. Indole has a wide range of biological activities such as; antioxidant, antidepressant, opioid antagonist, antihistaminic, anti-inflammatory, anticancer, anti-HIV, antiviral, antimicrobial, and antituberculosis.

This Special Issue is intended to collect suitable research articles or review articles on Recent Advances in Indole Derivatives in Medicinal and Synthetic Organic Chemistry to highlight recent research into the design, synthesis, different therapeutic applications, and in vitro and in silico studies of indole-based molecules to explore cutting age bioactive drug candidates. We hope that this Special Issue will make an important contribution to our knowledge of the recent advances in indole derivatives.

With your distinguished expertise in this area, we invite you to submit a paper to this Special Issue.

Prof. Dr. Khalid Mohammed Khan
Guest Editor

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