Advances in Synthesis and Biological Activity of Novel Derivatives Based on Five-Membered Heterocyclic Scaffolds and Their Intermediates

Dear Colleagues,

The five-membered heterocyclic compounds (imidazoles, pyrazoles, oxazoles, thiazoles, triazoles, oxadiazoles, thiadiazoles, etc.) are very important in pharmaceutical and medicinal chemistry, as it is known that representatives of this class are the basis of many drugs with various therapeutic actions, including antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, and antidiabetic activities. Currently, this field is being studied extensively by a large number of researchers in order to discover and develop new pharmaceutical agents and bioactive molecules. Thus, recent progress in synthetic approaches to nitrogen-, oxygen-, and sulfur-containing five-membered heterocycles include different synthesis protocols, such as multi-step strategies, multi-component pathways, photocatalysis, click reaction, microwave-assisted, and green synthesis, with pharmacologically potent derivatives reported.

This Special Issue aims to provide a survey of the recent advances in the synthesis and biological activity of novel derivatives based on five-membered heterocyclic scaffolds and their intermediates (N-acyl-α-amino acids, α-acylamino ketones, acyl hydrazones, acyl thioureas, hydrazinecarbothioamides, isocyanates, isothiocyanates, etc.). We invite you to contribute original research articles and/or reviews of the current scientific literature to this Special Issue of Molecules focused on the design, obtainment, and biological activity assessment of new pentatomic heterocyclic scaffolds and their intermediates.

Dr. Theodora Venera Apostol
Prof. Dr. George Mihai Nitulescu
Prof. Dr. Laura Ileana Socea
Guest Editors

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