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Special Issue "Combining synthesis and biosynthesis to access complex molecules"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 May 2019

Special Issue Editors

Guest Editor
Prof. Christopher N. Boddy

University of Ottawa, Canada, Department of Chemistry and Biomolecular Sciences, Ottawa, Canada
Website | E-Mail
Guest Editor
Dr. Graham Heberlig

University of Ottawa, Canada, Department of Chemistry and Biomolecular Sciences, Ottawa, Canada
Website | E-Mail

Special Issue Information

Dear Colleagues,

The construction of complex molecules has always benefited greatly from the field of biosynthesis. This can be clearly seen in the inspired biomimetic syntheses of complex molecules like tropinone, the daphnyphilum alkaloids, and the endiandric acids, and more recently in studies where enzymes from biosynthesis have been used to construct complex molecules such as the vancomycin aglycone core structure. The complementarity between modern synthetic chemistry and enzyme catalyzed reactions make the pairing of the two highly powerful. As natural product biosynthesis is providing researchers with an expanded biocatalyst toolbox and protein engineering is significantly improving the properties and function of these biocatalysts, many of the key hurdles to robust chemo-enzymatic pathways are being overcome. This Special Issue of Molecules is designed to capture the highly interdisciplinary interplay between synthesis and biosynthesis in accessing complex molecules. 

We welcome original articles as well as reviews of recent studies combining synthesis and biosynthesis, particularly focusing on chemo-enzymatic synthesis but also including enabling studies such as biomimetic total synthesis, new biocatalyst discovery, and in vitro biosynthesis.

Prof. Christopher N. Boddy
Dr. Graham Heberlig
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Biosynthesis
  • Chemoenzymatic
  • Biocatalysis
  • Tandem-catalysis
  • Precursor directed biosynthesis
  • Mutasynthesis
  • Biomimetic synthesis
  • Natural products
  • Polyketides
  • Non-ribosomal peptides
  • Ribosomally synthesized and post-translationally modified peptides
  • Terpenoids
  • Alkaloids
  • Carbohydrates

Published Papers

This special issue is now open for submission.
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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