Anticoagulant and Antithrombotic Therapy

Dear Colleagues,

It is our pleasure to announce the launch of a new Molecules Special Issue on “Anticoagulant and Antithrombotic Therapy”. Antiplatelet agents and anticoagulants represent a mainstay for the prevention and treatment of thrombosis-related diseases. However, despite the undoubted advances in antithrombotic therapy, bleeding still remains a major side effect. Understanding the mechanisms of hemostasis and thrombosis has revealed new targets for attenuating thrombosis with the potential for less bleeding.

The recently developed direct oral anticoagulants (DOACs), targeting coagulation cascade factors such as thrombin (dabigatran) or fXa (apixaban, edoxaban, and rivaroxaban), significantly expand the available warehouse of antithrombotic agents. The ultimate goal of anticoagulation therapy is to attenuate thrombosis without perturbing hemostasis, and DOACs come closer to this goal, without the elimination of bleeding risk. New targets (FXIIa and FXIa) or molecular strategies (allosteric inhibitors or modulators, antisense oligonucleotides, monoclonal antibodies, and aptamers) have evolved in the identification of new active compounds. This Special Issue will focus on the recent advances, current challenges, and future perspectives of antithrombotic agents.

Prof. Dr. Cosimo D. Altomare
Dr. Modesto De Candia
Dr. Rosa Purgatorio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.